Detailed view for TcCLB.506661.130

Basic information

TDR Targets ID: 44294
Trypanosoma cruzi, ion transport protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.9472 | Length (AA): 514 | MW (Da): 58912 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07885   Ion channel

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0016286   small conductance calcium-activated potassium channel activity  
GO:0006813   potassium ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
113 308 1orq (C) 35 237 13.00 0 0.02 0.57 -0.89
231 295 1lnq (A) 23 87 23.00 0.00000011 0.13 0.58 -2.21
208 295 2q67 (A) 1 91 25.00 0.069 0.07 0.344606 0.47
230 298 4h33 (A) 22 88 31.00 0.00039 0.06 0.363641 0.6
345 498 4tql (A) 9 163 6.00 0.19 0 0.349911 -0.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile epimastigote. Smircich P
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_138713)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0269864   hypothetical protein
Homo sapiens ENSG00000104783   potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Leishmania braziliensis LbrM.14.0530   ion transport protein-like protein
Leishmania donovani LdBPK_140550.1   ion transport protein-like protein
Leishmania infantum LinJ.14.0550   ion transport protein-like protein
Leishmania major LmjF.14.0540   ion transport protein-like protein
Leishmania mexicana LmxM.14.0540   ion transport protein-like protein
Mus musculus ENSMUSG00000054342   potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Trypanosoma cruzi TcCLB.506661.130   ion transport protein, putative
Trypanosoma cruzi TcCLB.511245.30   ion transport protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Human papillomavirus type 16 Protein E6 158 aa 22.4% 147 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0114 0.5886 1
0.0207 0.6303 0.5
0.0223 0.6565 0.5
0.0218 0.4281 1
0.0198 0.2993 0.4427
0.0114 0.273 0.5
0.0107 0.7209 0.5
0.0218 0.4281 1
0.034 0.8281 1
0.01 0.3785 0.5
0.0343 0.784 0.5
0.0569 0.8373 0.5
0.0224 0.2531 0.6111
0.0121 0.8227 0.5
0.0218 0.4281 1
0.0202 0.3607 1
0.0212 0.6921 0.5
0.0199 0.7209 0.5
0.0104 0.3277 0.5
0.0098 0.4065 1
0.0098 0.7769 1
0.0114 0.3685 0.5
0.0202 0.3768 0.4509
0.1407 0.3126 1
0.0306 0.6921 0.5497
0.0121 0.7209 0.5
0.0202 0.8338 1
0.0108 0.7209 0.5
0.0114 0.3685 0.5
0.0995 0.5314 1
0.0121 0.8193 1
0.0121 0.7209 0.5
0.0121 0.3652 1
0.0323 0.8354 0.5
0.0098 0.4065 1
0.0098 0.277 1
0.0103 0.2939 1
0.0218 0.5709 0.5783
0.0196 0.6926 0.5
0.0121 0.7209 0.5
0.0108 0.2903 0.5
0.0114 0.372 0.5
0.0108 0.4535 1
0.0121 0.7209 0.5
0.0557 0.8124 0.5
0.0097 0.4442 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.506661.130 (Trypanosoma cruzi), ion transport protein, putative
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