Detailed view for TcCLB.506835.70

Basic information

TDR Targets ID: 45940
Trypanosoma cruzi, PAS-domain containing phosphoglycerate kinase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.2364 | Length (AA): 527 | MW (Da): 57931 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00162   Phosphoglycerate kinase
PF00989   PAS fold

Gene Ontology

Mouse over links to read term descriptions.
GO:0006355   regulation of transcription, DNA-dependent  
GO:0004871   signal transducer activity  
GO:0004618   phosphoglycerate kinase activity  
GO:0007165   signal transduction  
GO:0006096   glycolysis  

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 55 4l9e (A) 144 200 19.00 0 0.6 0.216167 0.56
17 78 3fg8 (A) 130 191 18.00 0.16 0.8 0.322647 0.3
111 523 5bt8 (A) 0 395 40.00 0 1 1.20978 -0.55
121 520 1php (A) 3 392 42.00 0 1 1.30671 -1.09
121 520 3uwd (A) 3 392 41.00 0 1 1.29971 -1.18
121 523 1vpe (A) 3 398 44.00 0 1 1.31641 -1.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_161675)

Species Accession Gene Product
Leishmania braziliensis LbrM.30.3420   PAS-domain containing phosphoglycerate kinase, putative
Leishmania donovani LdBPK_303430.1   PAS-domain containing phosphoglycerate kinase, putative
Leishmania infantum LinJ.30.3430   PAS-domain containing phosphoglycerate kinase, putative
Leishmania major LmjF.30.3380   PAS-domain containing phosphoglycerate kinase, putative
Leishmania mexicana LmxM.29.3380   PAS-domain containing phosphoglycerate kinase, putative
Trypanosoma cruzi TcCLB.506835.70   PAS-domain containing phosphoglycerate kinase, putative
Trypanosoma cruzi TcCLB.506945.20   PAS-domain containing phosphoglycerate kinase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0075 0.296 0.0428
0.0063 0.3245 0.2778
0.0128 0.3047 0.3135
0.0075 0.3271 0.3271
0.0508 0.3604 0.3604
0.0075 0.322 0.3119
0.0075 0.2681 0.2681
0.0067 0.301 0.301
0.0064 0.2607 0.3336
0.025 0.2669 0.3295
0.0075 0.3147 0
0.0061 0.3247 0
0.0068 0.2504 0.2997
0.0063 0.3053 0.3053
0.0075 0.3271 0
0.0065 0.3024 0.2861
0.0105 0.2579 0.2841
0.0069 0.2552 0.3426
0.0358 0.2793 0.354
0.0075 0.3024 0
0.0508 0.3611 0.3611
0.0052 0.2576 0.353
0.0075 0.3271 0.3271
0.0091 0.2521 0.267
0.0578 0.3783 0.3775
0.0075 0.2848 0.1964
0.0038 0.3311 0.2853
0.0062 0.2885 0.2885
0.0064 0.2607 0.3336
0.0063 0.3024 0.3023
0.0219 0.316 0
0.0062 0.2736 0.33
0.0075 0.3271 0.2861
0.0075 0.2516 0.2279
0.0578 0.3783 0.3775
0.0067 0.295 0.2797
0.0065 0.3013 0
0.0075 0.3093 0
0.014 0.3018 0.2885
0.0062 0.2861 0.2861
0.0065 0.3199 0
0.0069 0.3084 0.2838
0.0093 0.2842 0
0.0061 0.3271 0
0.013 0.2704 0.3384
0.0067 0.301 0.301
0.0578 0.3783 0.3775
0.01 0.3032 0.3261
0.0064 0.26 0.2889
0.0065 0.262 0.3214
0.0061 0.3153 0.3173
0.0075 0.3271 0
0.0062 0.2804 0.344
0.0071 0.2782 0.3307
0.0096 0.2609 0
0.0075 0.3353 0.2885
0.0075 0.3002 0.257
0.0075 0.3084 0
0.0083 0.3643 0.1174
0.0105 0.2579 0.2841
0.007 0.3076 0.3036
0.0075 0.2885 0.2885
0.0075 0.2885 0.2885
0.0075 0.3188 0.3056
0.0086 0.2837 0.4759
0.0369 0.2833 0.3552
0.0307 0.3682 0.3682
0.0061 0.3252 0.3173
0.0075 0.3024 0
0.0075 0.301 0.301
0.0075 0.3272 0.2128
0.0075 0.284 0.1885
0.0091 0.2895 0.3478
0.0097 0.3203 0
0.0062 0.3024 0.3023
0.0578 0.3783 0.3775
0.0075 0.2605 0.2344
0.0073 0.3154 0.3062
0.0063 0.2861 0.2861
0.0086 0.2667 0.4558
0.0062 0.3134 0.2861
0.0135 0.3382 0.3335
0.0063 0.3001 0.2988
0.0075 0.257 0.257
0.0071 0.3037 0.2835
0.0067 0.301 0.301
0.0075 0.257 0.257
0.0075 0.2996 0.3192
0.0063 0.2605 0.2344
0.0061 0.296 0.0428
0.0062 0.2736 0.33
0.0062 0.2605 0.2344
0.0066 0.2944 0.2944
0.0136 0.2511 0.3486
0.0307 0.3682 0.3682
0.0064 0.3071 0

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.506835.70 (Trypanosoma cruzi), PAS-domain containing phosphoglycerate kinase, putative
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