Detailed view for TcCLB.458759.10

Basic information

TDR Targets ID: 47599
Trypanosoma cruzi, profilin, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.8257 | Length (AA): 150 | MW (Da): 16108 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00235   Profilin

Gene Ontology

Mouse over links to read term descriptions.
GO:0015629   actin cytoskeleton  
GO:0003779   actin binding  
GO:0007010   cytoskeleton organization and biogenesis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 119 1f2k (A) 1001 1116 28.00 0.000000000034 1 1.23 -1.46
2 150 1ypr (A) 1 125 37.00 0 1 1.37 -1.1
1 150 5fds (A) 1 131 40.00 0 1 1.3 -0.35
2 150 1f2k (A) 1001 1125 27.00 0 1 1.23863 -0.76
2 150 1ypr (A) 1 125 37.00 0.000000000032 1 1.33233 -0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127737)

Species Accession Gene Product
Arabidopsis thaliana AT4G29340   profilin 4
Arabidopsis thaliana AT2G19760   profilin 1
Arabidopsis thaliana AT2G19770   profilin 5
Arabidopsis thaliana AT4G29350   profilin 2
Arabidopsis thaliana AT5G56600   profilin 3
Brugia malayi Bm1_21620   Profilin family protein
Candida albicans CaO19.12542   can functionally substitute for S. cerevisiae actin-binding protein profilin (PFY1/YOR122C) which
Candida albicans CaO19.5076   can functionally substitute for S. cerevisiae actin-binding protein profilin (PFY1/YOR122C) which
Caenorhabditis elegans CELE_Y18D10A.20   Protein PFN-1
Caenorhabditis elegans CELE_K03E6.6   Protein PFN-3
Dictyostelium discoideum DDB_G0287125   profilin I
Dictyostelium discoideum DDB_G0271142   profilin III
Dictyostelium discoideum DDB_G0286187   profilin II
Drosophila melanogaster Dmel_CG9553   chickadee
Echinococcus granulosus EgrG_000122100   Profilin allergen
Entamoeba histolytica EHI_176140   profilin, putative
Entamoeba histolytica EHI_109900   profilin, putative
Echinococcus multilocularis EmuJ_000122100   Profilin allergen
Homo sapiens 375189   profilin family, member 4
Leishmania braziliensis LbrM.32.0570   profilin, putative
Leishmania donovani LdBPK_320550.1   profilin, putative
Leishmania infantum LinJ.32.0550   profilin, putative
Leishmania major LmjF.32.0520   profilin, putative
Leishmania mexicana LmxM.31.0520   profilin, putative
Loa Loa (eye worm) LOAG_01822   hypothetical protein
Loa Loa (eye worm) LOAG_04692   profilin
Mus musculus ENSMUSG00000020639   profilin family, member 4
Oryza sativa 4348317   Os10g0323900
Oryza sativa 4340155   Os06g0152100
Oryza sativa 4348316   Os10g0323600
Onchocerca volvulus OVOC2290  
Saccharomyces cerevisiae YOR122C   profilin
Schmidtea mediterranea mk4.000776.05  
Trypanosoma brucei gambiense Tbg972.11.15400   profilin, putative
Trypanosoma brucei Tb927.11.13780   profilin
Trypanosoma congolense TcIL3000.11.14170   profilin
Trypanosoma cruzi TcCLB.510911.10   profilin, putative
Trypanosoma cruzi TcCLB.458759.10   profilin, putative
Trichomonas vaginalis TVAG_242860   profilin, putative
Trichomonas vaginalis TVAG_454630   conserved hypothetical protein

Essentiality

TcCLB.458759.10 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.5350 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.5350 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.5350 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.5350 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y18D10A.20 Caenorhabditis elegans embryonic lethal wormbase
YOR122C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.458759.10 (Trypanosoma cruzi), profilin, putative
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