Detailed view for NCLIV_033380

Basic information

TDR Targets ID: 479297
Neospora caninum, hypothetical protein
Source Database / ID: 

pI: 7.1119 | Length (AA): 1528 | MW (Da): 166426 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00122   E1-E2 ATPase
PF00689   Cation transporting ATPase, C-terminus
PF00690   Cation transporter/ATPase, N-terminus
PF08282   haloacid dehalogenase-like hydrolase
PF13246   Cation transport ATPase (P-type)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0000166   nucleotide binding  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
125 1436 2o9j (A) 27 993 29.00 0 1 0.708439 1.27
263 415 5xaz (H) 55 207 14.00 0 0.02 0.290931 -0.72
931 1122 3a1c (A) 543 666 43.00 0.000000044 0.91 -0.0775456 1.75
1068 1119 3r4c (A) 203 253 41.00 0.1 0.8 0.481831 0.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126645)

Species Accession Gene Product
Arabidopsis thaliana AT3G22910   putative calcium-transporting ATPase 13
Arabidopsis thaliana AT4G29900   calcium-transporting ATPase 10
Arabidopsis thaliana AT3G57330   putative calcium-transporting ATPase 11
Arabidopsis thaliana AT5G57110   calcium-transporting ATPase 8
Arabidopsis thaliana AT3G63380   putative calcium-transporting ATPase 12
Arabidopsis thaliana AT5G53010   putative calcium-transporting ATPase
Arabidopsis thaliana AT3G21180   calcium-transporting ATPase 9
Arabidopsis thaliana AT2G22950   putative calcium-transporting ATPase 7
Arabidopsis thaliana AT1G27770   autoinhibited Ca2+-ATPase 1
Arabidopsis thaliana AT4G37640   calcium-transporting ATPase 2
Arabidopsis thaliana AT2G41560   autoinhibited Ca(2+)-ATPase 4
Brugia malayi Bm1_54565   Membrane calcium atpase protein 3
Brugia malayi Bm1_24355   calcium ATPase
Candida albicans CaO19.9295   possible calcium transporter
Candida albicans CaO19.1727   possible calcium transporter
Caenorhabditis elegans CELE_W09C2.3   Protein MCA-1, isoform A
Caenorhabditis elegans CELE_Y67D8C.10   Protein MCA-3, isoform C
Caenorhabditis elegans CELE_R05C11.3   Protein MCA-2
Dictyostelium discoideum DDB_G0289473   P-type ATPase
Dictyostelium discoideum DDB_G0277861   P-type ATPase
Drosophila melanogaster Dmel_CG42314   plasma membrane calcium ATPase
Echinococcus granulosus EgrG_001191500   plasma membrane calcium transporting ATPase 2
Echinococcus granulosus EgrG_001081900   plasma membrane calcium transporting ATPase
Echinococcus granulosus EgrG_000790100   Ca2 transporting ATPase plasma membrane
Entamoeba histolytica EHI_030830   Plasma membrane calcium-transporting ATPase, putative
Entamoeba histolytica EHI_136610   plasma membrane calcium ion-transporting ATPase, putative
Entamoeba histolytica EHI_159040   plasma membrane calcium ion-transporting ATPase, putative
Entamoeba histolytica EHI_001160   plasma membrane calcium-transporting ATPase, putative
Entamoeba histolytica EHI_054830   Plasma membrane calcium-transporting ATPase, putative
Entamoeba histolytica EHI_016480   Plasma membrane calcium-transporting ATPase, putative
Entamoeba histolytica EHI_001150   plasma membrane calcium-transporting ATPase 1, putative
Echinococcus multilocularis EmuJ_001191500   Tetracycline resistance leader peptide, TetL
Echinococcus multilocularis EmuJ_001081900   plasma membrane calcium transporting ATPase
Echinococcus multilocularis EmuJ_000790100   Ca2+ transporting ATPase plasma membrane
Giardia lamblia GL50803_32658   Plasma membrane calcium-transporting ATPase 2
Homo sapiens ENSG00000070961   ATPase, Ca++ transporting, plasma membrane 1
Homo sapiens ENSG00000058668   ATPase, Ca++ transporting, plasma membrane 4
Homo sapiens ENSG00000067842   ATPase, Ca++ transporting, plasma membrane 3
Homo sapiens ENSG00000157087   ATPase, Ca++ transporting, plasma membrane 2
Leishmania braziliensis LbrM.07.0720   vacuolar-type Ca2 -ATPase, putative
Leishmania braziliensis LbrM.07.0700   vacuolar-type Ca2 -ATPase, putative
Leishmania braziliensis LbrM.17.0590   P-type ATPase, putative
Leishmania donovani LdBPK_170660.1   P-type ATPase, putative
Leishmania infantum LinJ.07.0700   vacuolar-type Ca2 -ATPase, putative
Leishmania infantum LinJ.07.0510   vacuolar-type Ca2 -ATPase, putative
Leishmania infantum LinJ.17.0660   P-type ATPase, putative
Leishmania major LmjF.07.0630   vacuolar-type Ca2 -ATPase, putative
Leishmania major LmjF.17.0600   P-type ATPase, putative
Leishmania major LmjF.07.0650   vacuolar-type Ca2 -ATPase, putative
Leishmania mexicana LmxM.07.0630   vacuolar-type Ca2 -ATPase, putative
Leishmania mexicana LmxM.07.0650   vacuolar-type Ca2 -ATPase, putative
Leishmania mexicana LmxM.17.0600   P-type ATPase, putative
Loa Loa (eye worm) LOAG_08796   hypothetical protein
Loa Loa (eye worm) LOAG_14416   calcium ATPase
Loa Loa (eye worm) LOAG_06447   calcium ATPase
Loa Loa (eye worm) LOAG_05573   hypothetical protein
Loa Loa (eye worm) LOAG_05574   hypothetical protein
Mus musculus ENSMUSG00000030302   ATPase, Ca++ transporting, plasma membrane 2
Mus musculus 101056241   predicted gene, 29808
Mus musculus ENSMUSG00000026463   ATPase, Ca++ transporting, plasma membrane 4
Mus musculus ENSMUSG00000019943   ATPase, Ca++ transporting, plasma membrane 1
Mus musculus ENSMUSG00000031376   ATPase, Ca++ transporting, plasma membrane 3
Neospora caninum NCLIV_033380   hypothetical protein
Neospora caninum NCLIV_055720   hypothetical protein
Oryza sativa 4331984   Os03g0203700
Oryza sativa 9267724   Os08g0517200
Oryza sativa 4351449   Os12g0136900
Oryza sativa 4352664   Os12g0586600
Oryza sativa 4328480   Os02g0176700
Oryza sativa 4333451   Os03g0616400
Oryza sativa 4326507   Os01g0939100
Oryza sativa 4349735   Os11g0140400
Oryza sativa 4336912   Os04g0605500
Oryza sativa 4339199   Os05g0495600
Saccharomyces cerevisiae YGL006W   calcium-transporting ATPase PMC1
Schistosoma japonicum Sjp_0313890   Plasma membrane calcium-transporting ATPase 3, putative
Schistosoma japonicum Sjp_0086060   Plasma membrane calcium-transporting ATPase 3, putative
Schistosoma japonicum Sjp_0079000   Plasma membrane calcium-transporting ATPase 2, putative
Schistosoma japonicum Sjp_0009630   ko:K05850 Ca2+ transporting ATPase, plasma membrane, putative
Schistosoma japonicum Sjp_0109420   Plasma membrane calcium-transporting ATPase 3, putative
Schistosoma japonicum Sjp_0204190   Plasma membrane calcium-transporting ATPase 3, putative
Schistosoma mansoni Smp_176130   plasma membrane calcium-transporting atpase
Schistosoma mansoni Smp_137170   plasma membrane calcium-transporting atpase
Schmidtea mediterranea mk4.026656.00  
Schmidtea mediterranea mk4.021433.00  
Schmidtea mediterranea mk4.025718.00  
Schmidtea mediterranea mk4.024061.00  
Schmidtea mediterranea mk4.019468.00  
Schmidtea mediterranea mk4.048418.00  
Schmidtea mediterranea mk4.019772.01   Plasma membrane calcium ATPase
Schmidtea mediterranea mk4.019940.01   Plasma membrane calcium-transporting atpase,putative
Schmidtea mediterranea mk4.000119.04  
Schmidtea mediterranea mk4.000320.06   Plasma membrane calcium ATPase
Schmidtea mediterranea mk4.009491.00  
Schmidtea mediterranea mk4.000220.10  
Schmidtea mediterranea mk4.024698.05   Plasma membrane calcium ATPase
Schmidtea mediterranea mk4.003018.04   Putative plasma membrane calcium-transporting atpase
Schmidtea mediterranea mk4.026656.01  
Schmidtea mediterranea mk4.019784.01  
Schmidtea mediterranea mk4.031494.01  
Schmidtea mediterranea mk4.000220.11  
Schmidtea mediterranea mk4.068555.00   Plasma membrane calcium ATPase
Schmidtea mediterranea mk4.024044.00   Plasma membrane calcium ATPase
Schmidtea mediterranea mk4.006353.01  
Schmidtea mediterranea mk4.031494.00  
Schmidtea mediterranea mk4.024825.00  
Trypanosoma brucei gambiense Tbg972.8.740   vacuolar-type Ca2 -ATPase, putative
Trypanosoma brucei Tb927.8.1160   vacuolar-type Ca2+-ATPase, putative
Trypanosoma brucei Tb927.8.1180   vacuolar-type Ca2+-ATPase 1
Trypanosoma brucei Tb927.8.1200   vacuolar-type Ca2+-ATPase 2
Trypanosoma congolense TcIL3000_8_780   vacuolar-type Ca2+-ATPase, putative
Trypanosoma congolense TcIL3000_8_810   vacuolar-type Ca2+-ATPase, putative
Trypanosoma congolense TcIL3000_0_19160   vacuolar-type Ca2+-ATPase, putative
Trypanosoma cruzi TcCLB.508543.90   plasma membrane Ca2+ ATPase
Trypanosoma cruzi TcCLB.506401.170   plasma membrane Ca2+ ATPase
Toxoplasma gondii TGME49_312100   plasma membrane-type Ca(2+)-ATPase A1 PMCAA1
Toxoplasma gondii TGME49_233770   calcium-translocating P-type ATPase, PMCA-type protein
Trichomonas vaginalis TVAG_074420   cation-transporting ATPase fungi, putative
Trichomonas vaginalis TVAG_460580   plasma membrane calcium-transporting ATPase, putative
Trichomonas vaginalis TVAG_001610   plasma membrane calcium-transporting ATPase, putative
Trichomonas vaginalis TVAG_343600   plasma membrane calcium-transporting ATPase, putative
Trichomonas vaginalis TVAG_034600   plasma membrane calcium-transporting ATPase, putative
Trichomonas vaginalis TVAG_348080   plasma membrane calcium-transporting ATPase, putative
Trichomonas vaginalis TVAG_277590   cation-transporting ATPase, putative
Trichomonas vaginalis TVAG_178030   plasma membrane calcium-transporting ATPase, putative

Essentiality

NCLIV_033380 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.1160 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.1160 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.1160 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.1160 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_W09C2.3 Caenorhabditis elegans slow growth wormbase
CELE_Y67D8C.10 Caenorhabditis elegans adult lethal wormbase
CELE_Y67D8C.10 Caenorhabditis elegans embryonic arrest wormbase
CELE_R05C11.3 Caenorhabditis elegans slow growth wormbase
CELE_R05C11.3 Caenorhabditis elegans sterile wormbase
TGME49_233770 Toxoplasma gondii Probably non-essential sidik
TGME49_312100 Toxoplasma gondii Probably non-essential sidik
TGME49_233770 Toxoplasma gondii Probably essential sidik
TGME49_312100 Toxoplasma gondii Probably essential sidik
TGME49_233770 Toxoplasma gondii Essentiality uncertain sidik
TGME49_312100 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Trypanosoma cruzi plasma membrane Ca2+ ATPase Compounds References
Trypanosoma cruzi plasma membrane Ca2+ ATPase Compounds References
Schistosoma mansoni plasma membrane calcium-transporting atpase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier NCLIV_033380 (Neospora caninum), hypothetical protein
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