Detailed view for NCLIV_001690

Basic information

TDR Targets ID: 480576
Neospora caninum, Short-chain dehydrogenase/reductase SDR, related
Source Database / ID: 

pI: 6.2188 | Length (AA): 9820 | MW (Da): 1071448 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00107   Zinc-binding dehydrogenase
PF00109   Beta-ketoacyl synthase, N-terminal domain
PF00501   AMP-binding enzyme
PF00550   Phosphopantetheine attachment site
PF00698   Acyl transferase domain
PF02801   Beta-ketoacyl synthase, C-terminal domain
PF07993   Male sterility protein
PF08240   Alcohol dehydrogenase GroES-like domain
PF08659   KR domain
PF13469   Sulfotransferase family
PF14765   Polyketide synthase dehydratase
PF16197   Ketoacyl-synthetase C-terminal extension

Gene Ontology

Mouse over links to read term descriptions.
GO:0031177   phosphopantetheine binding  
GO:0016740   transferase activity  
GO:0016491   oxidoreductase activity  
GO:0003824   catalytic activity  
GO:0055114   oxidation reduction  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 51 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
26 732 4iz6 (A) 2 614 17.00 0 1 0.0298959 0.74
46 553 3e53 (A) 4 459 32.00 0 1 0.258631 -0.25
46 553 3t5a (A) 4 459 32.00 0 1 0.303631 -0.4
73 652 3kxw (A) 34 541 37.00 0 1 0.335763 -0.01
702 1128 4qyr (A) 2544 2973 46.00 0 1 0.615183 -0.76
706 1143 4opf (A) 6124 6542 42.00 0 1 0.310303 0
1077 1500 4qbu (A) 33 443 26.00 0 1 0.347077 -0.22
1150 1435 4rl1 (A) 28 308 26.00 0 1 0.431024 -0.9
1151 1472 3tzy (A) 713 1032 20.00 0 1 0.30769 -0.93
2073 2710 3slk (A) 105 716 37.00 0 1 0.351669 0.69
2081 2724 3slk (A) 115 730 27.00 0 1 0.20548 0.97
2276 2455 4oki (A) 670 849 31.00 0 1 0.42923 -0.8
2351 3295 3hmj (A) 465 1656 18.00 0 1 -0.0278678 1.16
2766 2853 5hv8 (A) 2051 2140 38.00 0.000000032 1 0.569861 -1.29
2875 3661 4mz0 (A) 41 920 44.00 0 1 0.514843 -0.59
2875 4885 2vz9 (A) 4 2090 28.00 0 1 0.281486 0.79
3311 3622 2qj3 (A) 0 297 21.00 0 1 0.291672 -0.75
3315 3639 4rl1 (A) 28 349 31.00 0 1 0.462996 -1.19
4643 4929 4l4x (A) 235 531 36.00 0 1 0.300926 0.14
4935 5018 2ju1 (A) 9 94 35.00 0 1 0.500454 -1.23
4941 5019 4neo (A) 8 85 21.00 0 0.8 0.397945 -1.83
4947 5016 3gzm (A) 6 77 21.00 0 0.98 0.398028 -1.69
5042 5466 2iwz (A) 40 457 25.00 0 1 0.277179 -0.33
5042 5467 1ox0 (A) 3 407 23.00 0 1 0.193281 -0.07
5049 5466 2ix4 (A) 33 459 23.00 0 1 0.287466 -0.48
5275 5358 4v0h (A) 30 125 35.00 0.58 0.19 0.218254 0.15
5497 5806 3el6 (A) 10 275 23.00 0 1 0.0784682 0.15
5499 5807 5tz5 (A) 963 1242 19.00 0 0.59 0.137366 -0.15
5499 5806 3kg6 (A) 1687 1964 20.00 0 0.9 0.143265 -0.1
5821 6656 3slk (A) 3 738 34.00 0 1 0.289032 0.58
6102 6316 1yb5 (A) 33 250 33.00 0 1 0.454594 -0.57
6102 6166 5tnx (A) 32 100 45.00 0.59 0.8 0.439319 0.13
6276 7290 2uv8 (A) 474 1726 16.00 0 1 -0.0457395 1.12
6339 6658 5ktk (A) 146 467 22.00 0 1 0.144487 0.66
6377 7452 3hmj (A) 629 1873 16.00 0 1 -0.0585277 1.41
6414 6664 4imp (A) 276 510 39.00 0 1 0.45246 -0.71
6421 6669 2z5l (A) 240 482 41.00 0 1 0.427056 -0.36
6689 6776 2liu (A) 1943 2034 33.00 0.0042 1 0.506661 -1.32
6762 7590 4mz0 (A) 4 934 41.00 0 1 0.45932 -0.33
6796 8731 2vz9 (A) 1 2073 26.00 0 1 0.222049 0.87
6796 7233 4qyr (A) 2544 2991 42.00 0 1 0.576503 -0.8
7250 7574 3h0p (A) 3 309 27.00 0 1 0.380996 -0.86
7253 7563 3qat (A) 5 307 25.00 0 1 0.38057 -0.97
8529 8789 3qp9 (D) 228 492 30.00 0 1 0.324278 0.08
8535 8770 5ktk (A) 222 466 34.00 0 1 0.351733 -0.12
8805 8878 2kr5 (A) 8 83 19.00 0.74 0.27 0.301436 -1.25
8963 9408 5msv (A) 721 1188 21.00 0 1 0.283318 -0.36
9009 9271 4u5q (A) 2090 2343 31.00 0 1 0.309482 -0.17
9015 9410 4w4t (A) 1129 1511 29.00 0 1 0.395226 -0.72
9413 9805 2zq5 (A) 7 382 30.00 0 1 0.38492 -0.53
9416 9809 2z6v (A) 7 384 25.00 0 1 0.333022 -0.59

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126633)

Species Accession Gene Product
Brugia malayi Bm1_08575   Beta-ketoacyl synthase, N-terminal domain containing protein
Brugia malayi Bm1_35180   oxidoreductase, zinc-binding dehydrogenase family protein
Caenorhabditis elegans CELE_F32H2.5   Protein FASN-1
Cryptosporidium hominis Chro.30258   hypothetical protein
Cryptosporidium hominis Chro.40330   hypothetical protein
Cryptosporidium parvum cgd4_2900   polyketide synthase
Cryptosporidium parvum cgd3_2180   type I fatty acid synthase
Dictyostelium discoideum DDB_G0281475   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0284001   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0271000   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0271614   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0291684   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290703   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0271530   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0288457   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0275077   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0291614   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0271618   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0271524   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290709   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0293912   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290729   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0295667   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0272981   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0275069   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0283931   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290943   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0271662   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290853   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290701   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290469   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0269364   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0270572   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0287095   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0291604   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0273007   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290937   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0282029   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0272859   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0282027   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0287119   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0292544   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0295659   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0293902   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290467   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290699   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0271520   beta-ketoacyl synthase family protein
Dictyostelium discoideum DDB_G0290737   beta-ketoacyl synthase family protein
Drosophila melanogaster Dmel_CG3523   CG3523 gene product from transcript CG3523-RA
Drosophila melanogaster Dmel_CG17374   CG17374 gene product from transcript CG17374-RC
Drosophila melanogaster Dmel_CG3524   CG3524 gene product from transcript CG3524-RB
Homo sapiens ENSG00000169710   fatty acid synthase
Loa Loa (eye worm) LOAG_12875   acyl carrier protein
Loa Loa (eye worm) LOAG_12856   hypothetical protein
Loa Loa (eye worm) LOAG_05412   fatty acid synthase
Loa Loa (eye worm) LOAG_06344   hypothetical protein
Loa Loa (eye worm) LOAG_05695   hypothetical protein
Mycobacterium leprae ML2353c   PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE
Mycobacterium leprae ML2356c   PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB
Mycobacterium leprae ML1229   PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4
Mycobacterium leprae ML2357c   PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA
Mycobacterium leprae ML2354c   PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD
Mycobacterium leprae ML0101   Polyketide synthase Pks13
Mycobacterium leprae ML0139   Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas
Mycobacterium leprae ML2355c   PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC
Mycobacterium leprae ML0135   Probable polyketide synthase Pks1
Mus musculus ENSMUSG00000025153   fatty acid synthase
Mycobacterium tuberculosis Rv2931   Phenolpthiocerol synthesis type-I polyketide synthase PpsA
Mycobacterium tuberculosis Rv2933   Phenolpthiocerol synthesis type-I polyketide synthase PpsC
Mycobacterium tuberculosis Rv2934   Phenolpthiocerol synthesis type-I polyketide synthase PpsD
Mycobacterium tuberculosis Rv2940c   Probable multifunctional mycocerosic acid synthase membrane-associated Mas
Mycobacterium tuberculosis Rv1527c   Probable polyketide synthase Pks5
Mycobacterium tuberculosis Rv1180   Probable polyketide beta-ketoacyl synthase Pks3
Mycobacterium tuberculosis Rv1181   Probable polyketide beta-ketoacyl synthase Pks4
Mycobacterium tuberculosis Rv2048c   Polyketide synthase Pks12
Mycobacterium tuberculosis Rv3800c   Polyketide synthase Pks13
Mycobacterium tuberculosis Rv0405   Probable membrane bound polyketide synthase Pks6
Mycobacterium tuberculosis Rv1661   Probable polyketide synthase Pks7
Mycobacterium tuberculosis Rv1662   Probable polyketide synthase Pks8
Mycobacterium tuberculosis Rv2935   Phenolpthiocerol synthesis type-I polyketide synthase PpsE
Mycobacterium tuberculosis Rv2932   Phenolpthiocerol synthesis type-I polyketide synthase PpsB
Mycobacterium tuberculosis Rv1664   Probable polyketide synthase Pks9
Mycobacterium tuberculosis Rv2947c   Probable polyketide synthase Pks15
Mycobacterium tuberculosis Rv2946c   Probable polyketide synthase Pks1
Mycobacterium tuberculosis Rv3825c   Polyketide synthase Pks2
Mycobacterium ulcerans MUP039c   Type I modular polyketide synthase
Mycobacterium ulcerans MUL_2018   phenolpthiocerol synthesis type-I polyketide synthase PpsB
Mycobacterium ulcerans MUP040c   Type I modular polyketide synthase
Mycobacterium ulcerans MUL_2005   polyketide synthase
Mycobacterium ulcerans MUL_1655   polyketide synthase Pks9
Mycobacterium ulcerans MUL_2016   phenolpthiocerol synthesis type-I polyketide synthase PpsD
Mycobacterium ulcerans MUL_2010   multifunctional mycocerosic acid synthase membrane-associated Mas
Mycobacterium ulcerans MUL_2015   phenolpthiocerol synthesis type-I polyketide synthase PpsE
Mycobacterium ulcerans MUP032c   Type I modular polyketide synthase
Mycobacterium ulcerans MUL_2266   polyketide synthase
Mycobacterium ulcerans MUL_2019   phenolpthiocerol synthesis type-I polyketide synthase PpsA
Mycobacterium ulcerans MUL_4983   polyketide synthase Pks13
Mycobacterium ulcerans MUL_2017   phenolpthiocerol synthesis type-I polyketide synthase PpsC
Neospora caninum NCLIV_001690   Short-chain dehydrogenase/reductase SDR, related
Neospora caninum NCLIV_020690   Soraphen polyketide synthase A, related
Neospora caninum NCLIV_050890   KR domain domain-containing protein, putative
Onchocerca volvulus OVOC1839  
Onchocerca volvulus OVOC5784   Fatty acid synthase homolog
Schmidtea mediterranea mk4.052433.01  
Toxoplasma gondii TGME49_294820   type I fatty acid synthase, putative
Toxoplasma gondii TGME49_204560   type I fatty acid synthase, putative
Toxoplasma gondii TGME49_326200   type I fatty acid synthase
Toxoplasma gondii TGME49_236990   beta-ketoacyl synthase, N-terminal domain-containing protein
Toxoplasma gondii TGME49_236980   AMP-binding enzyme domain-containing protein

Essentiality

NCLIV_001690 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2988 Mycobacterium tuberculosis non-essential nmpdr
mtu3867 Mycobacterium tuberculosis essential nmpdr
mtu408 Mycobacterium tuberculosis non-essential nmpdr
mtu1690 Mycobacterium tuberculosis essential nmpdr
mtu1691 Mycobacterium tuberculosis essential nmpdr
mtu2981 Mycobacterium tuberculosis non-essential nmpdr
CELE_F32H2.5 Caenorhabditis elegans embryonic arrest wormbase
CELE_F32H2.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_F32H2.5 Caenorhabditis elegans larval arrest wormbase
CELE_F32H2.5 Caenorhabditis elegans sterile wormbase
TGME49_294820 Toxoplasma gondii Essentiality uncertain sidik
TGME49_204560 Toxoplasma gondii Essentiality uncertain sidik
TGME49_236990 Toxoplasma gondii Essentiality uncertain sidik
TGME49_236980 Toxoplasma gondii Essentiality uncertain sidik
TGME49_326200 Toxoplasma gondii Essentiality uncertain sidik
TGME49_294820 Toxoplasma gondii Probably non-essential sidik
TGME49_204560 Toxoplasma gondii Probably non-essential sidik
TGME49_236990 Toxoplasma gondii Probably non-essential sidik
TGME49_236980 Toxoplasma gondii Probably non-essential sidik
TGME49_326200 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens fatty acid synthase Compounds References
Rattus norvegicus Fatty acid synthase Compounds References
Gallus gallus Fatty acid synthase Compounds References
Mus musculus fatty acid synthase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Staphylococcus aureus 3-oxoacyl-[acyl-carrier-protein] synthase 2 403 aa 23.4% 415 aa Compounds References
Photuris pennsylvanica Luciferin 4-monooxygenase 545 aa 19.8% 529 aa Compounds References
Luciola lateralis Luciferase 548 aa 22.2% 541 aa Compounds References
Photinus pyralis Luciferin 4-monooxygenase 550 aa 19.1% 518 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier NCLIV_001690 (Neospora caninum), Short-chain dehydrogenase/reductase SDR, related
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