Detailed view for TcCLB.506297.110

Basic information

TDR Targets ID: 51207
Trypanosoma cruzi, ATPase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.2722 | Length (AA): 1236 | MW (Da): 138972 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00004   ATPase family associated with various cellular activities (AAA)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0000166   nucleotide binding  
GO:0017111   nucleoside-triphosphatase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
104 716 1ypw (A) 17 617 27.00 0 1 0.67 0.94
300 529 1ixz (A) 153 374 41.00 0 1 0.7 -1.08
325 774 2dhr (A) 177 592 25.00 0.00000000016 1 0.5 0.33
23 235 5xg2 (A) 354 793 12.00 0.8 0.01 0.25433 -0.3
152 575 4ko8 (A) 56 467 35.00 0 1 0.625142 0.3
299 542 5eqt (A) 102 335 46.00 0 1 0.718511 -0.39
482 539 2dzn (D) 349 402 31.00 0 0.96 0.431026 -0.81
895 1027 3lxj (A) 961 1077 22.00 0 1 0.354705 -0.96
899 1023 3lxj (A) 961 1080 23.00 0.49 1 0.534233 -1.61
1017 1235 4tql (A) 9 235 9.00 0.016 0 0.271184 -0.43

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128668)

Species Accession Gene Product
Arabidopsis thaliana AT1G05910   cell division cycle protein 48-related protein
Brugia malayi Bm1_28240   ATPase, AAA family protein
Candida albicans CaO19.3949   potential ATPase similar to S. cerevisiae YTA7 (YGR270W)
Candida albicans CaO19.11431   potential ATPase similar to S. cerevisiae YTA7 (YGR270W)
Caenorhabditis elegans CELE_F11A10.1   Protein LEX-1, isoform A
Dictyostelium discoideum DDB_G0281521   AAA ATPase domain-containing protein
Echinococcus granulosus EgrG_000184500   ATPase family AAA domain containing protein 2B
Echinococcus multilocularis EmuJ_000184500   ATPase family AAA domain containing protein 2B
Homo sapiens ENSG00000119778   ATPase family, AAA domain containing 2B
Homo sapiens ENSG00000156802   ATPase family, AAA domain containing 2
Leishmania braziliensis LbrM.11.0710   ATPase, putative
Leishmania donovani LdBPK_110910.1   ATPase, putative
Leishmania infantum LinJ.11.0910   ATPase, putative
Leishmania major LmjF.11.0910   ATPase, putative
Leishmania mexicana LmxM.11.0910   ATPase, putative
Loa Loa (eye worm) LOAG_05966   hypothetical protein
Mus musculus 320817   ATPase family, AAA domain containing 2B
Mus musculus ENSMUSG00000022360   ATPase family, AAA domain containing 2
Oryza sativa 4347572   Os09g0515100
Saccharomyces cerevisiae YGR270W   Yta7p
Schistosoma japonicum Sjp_0122290   ATPase family AAA domain-containing protein 2, putative
Schistosoma mansoni Smp_179280   hypothetical protein
Schmidtea mediterranea mk4.001113.02  
Schmidtea mediterranea mk4.001113.01  
Trypanosoma brucei gambiense Tbg972.11.7170   AAA ATPase, putative
Trypanosoma brucei Tb927.11.6350   AAA ATPase, putative
Trypanosoma congolense TcIL3000.11.6910   AAA ATPase, putative
Trypanosoma congolense TcIL3000_0_14900   AAA ATPase, putative
Trypanosoma cruzi TcCLB.506297.110   ATPase, putative

Essentiality

TcCLB.506297.110 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.4210 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.4210 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.4210 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.4210 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F11A10.1 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ATPase family, AAA domain containing 2B Compounds References
Homo sapiens ATPase family, AAA domain containing 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0064 0.4205 0.5
0.034 0.3756 0.3711
0.0211 0.3588 0.7961
0.0989 0.5574 1
0.0406 0.401 0.5297
0.126 0.3995 1
0.0064 0.4205 0.5
0.0807 0.4771 0.5
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0805 0.6462 1
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0064 0.3724 0.5
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.034 0.3756 0.3711
0.0406 0.401 0.5297
0.2128 0.511 1
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0211 0.3588 0.7961
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0804 0.4751 0.5
0.1254 0.5425 1
0.0064 0.4205 0.5
0.0684 0.5377 0.5
0.0211 0.3588 0.7961
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0677 0.4263 1
0.0714 0.5949 1
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0942 0.46 1
0.0581 0.7301 1
0.0064 0.4205 0.5
0.0677 0.4263 1
0.0813 0.7716 1
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.074 0.433 0.5
0.0064 0.4205 0.5
0.0677 0.4263 1
0.0064 0.4205 0.5
0.0997 0.6801 1
0.2128 0.511 1
0.1197 0.3464 1
0.0064 0.4205 0.5
0.0919 0.6611 1
0.126 0.3995 1
0.0064 0.4205 0.5
0.0714 0.5252 1
0.034 0.3645 1
0.0064 0.4205 0.5
0.0741 0.4083 1
0.0064 0.4205 0.5
0.0486 0.4994 1
0.0064 0.4205 0.5
0.1161 0.3782 1
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0563 0.4597 1
0.0064 0.4205 0.5
0.0662 0.3835 1
0.068 0.3731 1
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0128 0.4157 1
0.0064 0.4205 0.5
0.0677 0.4263 1
0.0406 0.401 0.5297
0.0064 0.4205 0.5
0.0285 0.2975 1
0.0921 0.7829 1
0.0942 0.46 1
0.1035 0.6762 1
0.0808 0.6252 0.5
0.1161 0.3782 1
0.0927 0.7045 1
0.2128 0.511 1
0.0808 0.4741 0.5
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0064 0.4205 0.5
0.0211 0.3588 0.7961
0.1035 0.6762 1
0.1069 0.7143 1
0.074 0.433 0.5
0.0064 0.4205 0.5
0.0662 0.3835 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TcCLB.506297.110 (Trypanosoma cruzi), ATPase, putative
Title for this comment
Comment