pI: 9.7219 |
Length (AA): 2133 |
MW (Da): 240894 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
203 | 333 | 5hmo (A) | 801 | 924 | 18.00 | 0.094 | 0 | 0.171316 | -0.29 |
483 | 1212 | 5g0j (A) | 63 | 809 | 18.00 | 0 | 1 | 0.030141 | 1.23 |
670 | 708 | 2pne (A) | 17 | 55 | 49.00 | 0.29 | 0.22 | 0.444384 | 0.72 |
1856 | 2067 | 2iew (A) | 74 | 356 | 22.00 | 0 | 1 | 0.206291 | 0.23 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126654)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G61060 | histone deacetylase 5 |
Arabidopsis thaliana | AT1G08460 | histone deacetylase 8 |
Arabidopsis thaliana | AT3G18520 | histone deacetylase 15 |
Arabidopsis thaliana | AT5G61070 | histone deacetylase 18 |
Arabidopsis thaliana | AT4G33470 | histone deacetylase 14 |
Babesia bovis | BBOV_IV001800 | histone deacetylase, putative |
Brugia malayi | Bm1_04175 | Histone deacetylase family protein |
Brugia malayi | Bm1_29305 | Histone deacetylase family protein |
Candida albicans | CaO19.2606 | strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit |
Candida albicans | CaO19.10137 | strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit |
Caenorhabditis elegans | CELE_C10E2.3 | Protein HDA-4, isoform B |
Caenorhabditis elegans | CELE_F41H10.6 | Protein HDA-6, isoform D |
Cryptosporidium hominis | Chro.80061 | hypothetical protein |
Cryptosporidium parvum | cgd8_480 | histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus |
Dictyostelium discoideum | DDB_G0280195 | FYVE-type zinc finger-containing protein |
Drosophila melanogaster | Dmel_CG6170 | CG6170 gene product from transcript CG6170-RA |
Drosophila melanogaster | Dmel_CG1770 | CG1770 gene product from transcript CG1770-RG |
Echinococcus granulosus | EgrG_000971000 | histone deacetylase 6 |
Echinococcus granulosus | EgrG_000970900 | histone deacetylase 6 |
Echinococcus granulosus | EgrG_000970800 | histone deacetylase 6 |
Echinococcus granulosus | EgrG_000831600 | histone deacetylase 7 |
Echinococcus granulosus | EgrG_000527350 | histone deacetylase |
Echinococcus multilocularis | EmuJ_000970800 | histone deacetylase 6 |
Echinococcus multilocularis | EmuJ_000970900 | histone deacetylase 6 |
Echinococcus multilocularis | EmuJ_000527350 | histone deacetylase |
Echinococcus multilocularis | EmuJ_000831600 | histone deacetylase 7 |
Echinococcus multilocularis | EmuJ_000971000 | histone deacetylase 6 |
Homo sapiens | ENSG00000094631 | histone deacetylase 6 |
Homo sapiens | ENSG00000048052 | histone deacetylase 9 |
Homo sapiens | ENSG00000068024 | histone deacetylase 4 |
Homo sapiens | ENSG00000061273 | histone deacetylase 7 |
Homo sapiens | ENSG00000100429 | histone deacetylase 10 |
Homo sapiens | ENSG00000108840 | histone deacetylase 5 |
Leishmania braziliensis | LbrM.08.0840 | histone deacetylase, putative |
Leishmania braziliensis | LbrM.33.0940 | histone deacetylase, putative |
Leishmania donovani | LdBPK_081300.1 | histone deacetylase, putative |
Leishmania donovani | LdBPK_081000.1 | histone deacetylase, putative |
Leishmania infantum | LinJ.08.1300 | histone deacetylase, putative |
Leishmania infantum | LinJ.08.1000 | histone deacetylase, putative |
Leishmania major | LmjF.08.1090 | histone deacetylase, putative |
Leishmania major | LmjF.21.1870 | histone deacetylase, putative |
Leishmania mexicana | LmxM.08.1090 | histone deacetylase, putative |
Leishmania mexicana | LmxM.21.1870 | histone deacetylase, putative |
Loa Loa (eye worm) | LOAG_12874 | histone deacetylase 7A |
Loa Loa (eye worm) | LOAG_08981 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12935 | histone deacetylase |
Loa Loa (eye worm) | LOAG_02425 | hypothetical protein |
Mus musculus | ENSMUSG00000062906 | histone deacetylase 10 |
Mus musculus | ENSMUSG00000008855 | histone deacetylase 5 |
Mus musculus | ENSMUSG00000004698 | histone deacetylase 9 |
Mus musculus | ENSMUSG00000022475 | histone deacetylase 7 |
Mus musculus | ENSMUSG00000031161 | histone deacetylase 6 |
Mus musculus | ENSMUSG00000026313 | histone deacetylase 4 |
Neospora caninum | NCLIV_023370 | hypothetical protein |
Oryza sativa | 4351682 | Os12g0182700 |
Oryza sativa | 4342472 | Os07g0164100 |
Oryza sativa | 4338920 | Os05g0440100 |
Oryza sativa | 4343829 | Os07g0602200 |
Plasmodium berghei | PBANKA_1206200 | histone deacetylase 2, putative |
Plasmodium berghei | PBANKA_1335400 | histone deacetylase, putative |
Plasmodium falciparum | PF3D7_1008000 | histone deacetylase 2 |
Plasmodium falciparum | PF3D7_1472200 | histone deacetylase, putative |
Plasmodium knowlesi | PKNH_0807000 | histone deacetylase 2, putative |
Plasmodium knowlesi | PKNH_1208800 | histone deacetylase, putative |
Plasmodium vivax | PVX_116870 | histone deacetylase, putative |
Plasmodium vivax | PVX_094595 | histone deacetylase 2, putative |
Plasmodium yoelii | PY05395 | hypothetical protein |
Plasmodium yoelii | PY07179 | Histone deacetylase family, putative |
Saccharomyces cerevisiae | YNL021W | Hda1p |
Schistosoma japonicum | Sjp_0055900 | Histone deacetylase 10, putative |
Schistosoma japonicum | Sjp_0055920 | Histone deacetylase 10, putative |
Schistosoma japonicum | Sjp_0002050 | Histone deacetylase 4, putative |
Schistosoma japonicum | Sjp_0036460 | Histone deacetylase 4, putative |
Schistosoma japonicum | Sjp_0109880 | IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing |
Schistosoma japonicum | Sjp_0311640 | Histone deacetylase 6, putative |
Schistosoma japonicum | Sjp_0130630 | hypothetical protein |
Schistosoma japonicum | Sjp_0055910 | Histone deacetylase 6, putative |
Schistosoma mansoni | Smp_191310 | histone deacetylase 4 5 |
Schistosoma mansoni | Smp_069380 | histone deacetylase 4 5 |
Schistosoma mansoni | Smp_138770 | histone deacetylase hda2 |
Schmidtea mediterranea | mk4.000224.06 | Histone deacetylase 10 |
Schmidtea mediterranea | mk4.003136.00 | Histone deacetylase 4 |
Trypanosoma brucei gambiense | Tbg.972.2.760 | histone deacetylase, putative |
Trypanosoma brucei | Tb927.2.2190 | histone deacetylase 3 |
Trypanosoma brucei | Tb11.v5.0660 | histone deacetylase, putative |
Trypanosoma brucei | Tb927.5.2900 | histone deacetylase 4 |
Trypanosoma congolense | TcIL3000_0_22870 | histone deacetylase 4 |
Trypanosoma congolense | TcIL3000_5_3160 | histone deacetylase 4 |
Trypanosoma congolense | TcIL3000_0_22520 | histone deacetylase, putative |
Trypanosoma cruzi | TcCLB.509395.120 | histone deacetylase, putative |
Trypanosoma cruzi | TcCLB.503653.50 | histone deacetylase, putative |
Trypanosoma cruzi | TcCLB.507063.270 | histone deacetylase, putative |
Toxoplasma gondii | TGME49_281420 | histone deacetylase HDAC1 |
Theileria parva | TP03_0788 | hypothetical protein |
Theileria parva | TP03_0613 | hypothetical protein |
Theileria parva | TP03_0612 | histone deacetylase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.2.2190 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.2190 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.2190 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.2.2190 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.5.2900 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.2900 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.2900 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.2900 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C10E2.3 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1206200 | Plasmodium berghei | Essential | plasmo |
TGME49_281420 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | histone deacetylase 5 | Compounds | References |
Alcaligenes sp. (strain DSM 11172) (Bordetella sp. (strain FB188)) | Histone deacetylase-like amidohydrolase | Compounds | References |
Mus musculus | histone deacetylase 9 | Compounds | References |
Rattus norvegicus | Histone deacetylase 6 | Compounds | References |
Homo sapiens | histone deacetylase 5 | Compounds | References |
Mus musculus | histone deacetylase 4 | Compounds | References |
Homo sapiens | histone deacetylase 4 | Compounds | References |
Homo sapiens | histone deacetylase 10 | Compounds | References |
Homo sapiens | histone deacetylase 7 | Compounds | References |
Mus musculus | histone deacetylase 6 | Compounds | References |
Homo sapiens | histone deacetylase 9 | Compounds | References |
Mus musculus | histone deacetylase 7 | Compounds | References |
Mus musculus | histone deacetylase 10 | Compounds | References |
Homo sapiens | histone deacetylase 6 | Compounds | References |