pI: 8.6458 |
Length (AA): 470 |
MW (Da): 55065 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: Y | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
65 | 350 | 4n6o (A) | 28 | 287 | 19.00 | 0 | 1 | 0.833211 | -0.81 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128053)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G08750 | putative glycosylphosphatidylinositol-anchor transamidase |
Babesia bovis | BBOV_I000200 | conserved hypothetical protein |
Brugia malayi | Bm1_16030 | GPI-anchor transamidase |
Candida albicans | CaO19.10317 | similar to S. cerevisiae GPI8 (YDR331W) subunit of GPI transamidase complex |
Candida albicans | CaO19.2799 | similar to S. cerevisiae GPI8 (YDR331W) subunit of GPI transamidase complex |
Caenorhabditis elegans | CELE_T05E11.6 | Protein HPO-4 |
Cryptosporidium hominis | Chro.10032 | GPI-anchor transamidase (U32517) -related |
Cryptosporidium parvum | cgd1_220 | glycosylphosphatidylinositol transamidase, involved in GPI anchor biosynthesis |
Dictyostelium discoideum | DDB_G0285461 | phosphatidylinositol glycan, class K |
Drosophila melanogaster | Dmel_CG4406 | CG4406 gene product from transcript CG4406-RA |
Echinococcus granulosus | EgrG_000869600 | GPI anchor transamidase |
Entamoeba histolytica | EHI_092280 | GPI-anchor transamidase, putative |
Echinococcus multilocularis | EmuJ_000869600 | GPI anchor transamidase |
Giardia lamblia | GL50803_15267 | GPI-anchor transamidase, putative |
Homo sapiens | ENSG00000142892 | phosphatidylinositol glycan anchor biosynthesis, class K |
Leishmania braziliensis | LbrM.18.0380 | GPI-anchor transamidase subunit 8 (GPI8), putative |
Leishmania donovani | LdBPK_180360.1 | GPI-anchor transamidase subunit 8 (GPI8), putative |
Leishmania infantum | LinJ.18.0360 | GPI-anchor transamidase subunit 8 (GPI8), putative |
Leishmania major | LmjF.18.0360 | GPI-anchor transamidase subunit 8 (GPI8), putative |
Leishmania mexicana | LmxM.18.0360 | GPI-anchor transamidase subunit 8 (GPI8), putative,cysteine peptidase, Clan CD, family C13, putative |
Loa Loa (eye worm) | LOAG_06136 | hypothetical protein |
Mus musculus | ENSMUSG00000039047 | phosphatidylinositol glycan anchor biosynthesis, class K |
Neospora caninum | NCLIV_007520 | hypothetical protein |
Oryza sativa | 4328747 | Os02g0219400 |
Plasmodium berghei | PBANKA_0919500 | GPI-anchor transamidase, putative |
Plasmodium falciparum | PF3D7_1128700 | GPI-anchor transamidase, putative |
Plasmodium knowlesi | PKNH_0926800 | GPI-anchor transamidase, putative |
Plasmodium vivax | PVX_092055 | GPI-anchor transamidase, putative |
Plasmodium yoelii | PY03470 | GPI8p transamidase-related |
Saccharomyces cerevisiae | YDR331W | Gpi8p |
Schistosoma japonicum | Sjp_0124340 | ko:K05290 phosphatidylinositol glycan, class K, putative |
Schistosoma japonicum | Sjp_0074300 | Putative GPI-anchor transamidase precursor, putative |
Schistosoma mansoni | Smp_011230 | glycosylphosphatidylinositol:protein transamidase (C13 family) |
Schmidtea mediterranea | mk4.003944.01 | Putative GPI-anchor transamidase |
Trypanosoma brucei gambiense | Tbg972.10.17040 | GPI-anchor transamidase subunit 8 (GPI8),cysteine peptidase, Clan CD, family C13, putative |
Trypanosoma brucei | Tb927.10.13860 | GPI-anchor transamidase subunit 8 (GPI8) |
Trypanosoma congolense | TcIL3000_10_11820 | GPI-anchor transamidase subunit 8 (GPI8) |
Trypanosoma cruzi | TcCLB.511277.450 | cysteine peptidase, Clan CD, family C13, putative |
Toxoplasma gondii | TGME49_252440 | peptidase c13 family protein |
Theileria parva | TP03_0846 | GPI-anchor transamidase, putative |
Trichomonas vaginalis | TVAG_277470 | Clan CD, family C13, legumain-like cysteine peptidase |
Trichomonas vaginalis | TVAG_035520 | Clan CD, family C13, legumain-like cysteine peptidase |
Trichomonas vaginalis | TVAG_060430 | Clan CD, family C13, legumain-like cysteine peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.13860 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.13860 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.13860 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.13860 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
YDR331W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0919500 | Plasmodium berghei | Essential | plasmo |
TGME49_252440 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Leishmania major | GPI-anchor transamidase subunit 8 (GPI8), putative | Compounds | References |