Detailed view for PY01244

Basic information

TDR Targets ID: 538255
Plasmodium yoelii, hypothetical protein

Source Database / ID:

pI: 9.6616 | Length (AA): 283 | MW (Da): 33513 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: ND

Pfam domains

PF11539   Protein of unknown function (DUF3228)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Network

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models: 0

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_136245)
Species Accession Gene Product
Babesia bovis BBOV_III001670   conserved hypothetical protein
Cryptosporidium hominis Chro.20219   hypothetical protein
Cryptosporidium parvum cgd2_2020   hypothetical protein
Neospora caninum NCLIV_021510   hypothetical protein, conserved
Plasmodium berghei PBANKA_0208600   conserved protein, unknown function
Plasmodium falciparum PF3D7_0104500   conserved protein, unknown function
Plasmodium knowlesi PKNH_0209000   conserved protein, unknown function
Plasmodium vivax PVX_081530   hypothetical protein, conserved
Plasmodium yoelii PY01244   hypothetical protein
Toxoplasma gondii TGME49_203450   DUF3228 domain-containing protein
Theileria parva TP03_0673   hypothetical protein, conserved
Trichomonas vaginalis TVAG_131160   conserved hypothetical protein

Essentiality

PY01244 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_203450 Toxoplasma gondii Probably essential sidik

Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Curated from literature

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PY01244 (Plasmodium yoelii), hypothetical protein
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TDR Targets Development Release v6, Revision: 1335 (10.Aug.2018)
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