Detailed view for Tbg972.4.4450

Basic information

TDR Targets ID: 539233
Trypanosoma brucei gambiense, monoglyceride lipase, putative
Source Database / ID: 

pI: 6.4204 | Length (AA): 310 | MW (Da): 35005 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12146   Serine aminopeptidase, S33

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
17 308 4zwn (A) 1 306 19.00 0 1 1.21124 -0.45
19 309 3pe6 (A) 7 294 32.00 0 1 1.41611 -1.07
23 90 1imj (A) 2 68 21.00 0.027 0.12 0.355755 -0.04
51 188 2yys (A) 19 142 34.00 0.22 0.87 0.587961 0.59

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127037)

Species Accession Gene Product
Arabidopsis thaliana AT3G55180   alpha/beta-Hydrolases superfamily protein
Arabidopsis thaliana AT5G11650   alpha/beta fold hydrolase family protein
Arabidopsis thaliana AT1G18360   alpha/beta-Hydrolases superfamily protein
Arabidopsis thaliana AT2G39400   alpha/beta-Hydrolases superfamily protein
Arabidopsis thaliana AT2G39420   alpha/beta-Hydrolases superfamily protein
Arabidopsis thaliana AT1G73480   alpha/beta-Hydrolases superfamily protein
Candida albicans CaO19.12328   similar to YJU3
Candida albicans CaO19.4864   similar to YJU3
Dictyostelium discoideum DDB_G0276087   hypothetical protein
Dictyostelium discoideum DDB_G0269086   alpha/beta hydrolase fold-1 domain-containing protein
Escherichia coli b1410   putative esterase
Entamoeba histolytica EHI_044210   hydrolase, alpha/beta fold family domain containing protein
Entamoeba histolytica EHI_039840   hydrolase, alpha/beta fold family domain containing protein
Homo sapiens ENSG00000074416   monoglyceride lipase
Leishmania braziliensis LbrM.31.1340   monoglyceride lipase, putative
Leishmania donovani LdBPK_311150.1   monoglyceride lipase, putative
Leishmania infantum LinJ.31.1150   monoglyceride lipase, putative
Leishmania major LmjF.31.1140   monoglyceride lipase, putative
Leishmania mexicana LmxM.30.1140   monoglyceride lipase, putative
Mycobacterium leprae ML2603   POSSIBLE LYSOPHOSPHOLIPASE
Mus musculus ENSMUSG00000033174   monoglyceride lipase
Mycobacterium tuberculosis Rv0183   Possible lysophospholipase
Mycobacterium ulcerans MUL_0089   hypothetical protein
Mycobacterium ulcerans MUL_1077   lysophospholipase
Oryza sativa 4351922   Os12g0262700
Oryza sativa 4333927   Os03g0719400
Oryza sativa 4346971   Os09g0394700
Oryza sativa 4327343   Os01g0199400
Plasmodium falciparum PF3D7_1038900   esterase, putative
Plasmodium falciparum PF3D7_0937200   lysophospholipase, putative
Plasmodium falciparum PF3D7_1476700   lysophospholipase, putative
Plasmodium falciparum PF3D7_1476800   lysophospholipase, putative
Plasmodium vivax PVX_096960   PST-A protein
Saccharomyces cerevisiae YKL094W   Yju3p
Schmidtea mediterranea mk4.006872.02  
Schmidtea mediterranea mk4.002673.02  
Schmidtea mediterranea mk4.000137.11  
Schmidtea mediterranea mk4.000137.13  
Schmidtea mediterranea mk4.000137.12  
Schmidtea mediterranea mk4.012753.00  
Schmidtea mediterranea mk4.011109.00  
Schmidtea mediterranea mk4.020061.00  
Trypanosoma brucei gambiense Tbg972.4.4450   monoglyceride lipase, putative
Trypanosoma brucei gambiense Tbg972.8.8340   monoglyceride lipase, putative
Trypanosoma brucei Tb927.4.4360   monoglyceride lipase, putative
Trypanosoma brucei Tb927.8.8020   monoglyceride lipase, putative
Trypanosoma congolense TcIL3000_8_8050   monoglyceride lipase, putative
Trypanosoma congolense TcIL3000_8_8180   monoglyceride lipase, putative
Trypanosoma congolense TcIL3000_4_3730   monoglyceride lipase, putative
Trypanosoma cruzi TcCLB.506489.20   monoglyceride lipase, putative
Trichomonas vaginalis TVAG_165300   Clan SC, family S33, methylesterase-like serine peptidase
Trichomonas vaginalis TVAG_106830   Clan SC, family S33, methylesterase-like serine peptidase
Trichomonas vaginalis TVAG_077180   conserved hypothetical protein
Trichomonas vaginalis TVAG_074970   Clan SC, family S33, methylesterase-like serine peptidase
Trichomonas vaginalis TVAG_373610   Clan SC, family S33, methylesterase-like serine peptidase
Trichomonas vaginalis TVAG_032110   Clan SC, family S33, methylesterase-like serine peptidase
Trichomonas vaginalis TVAG_295890   valacyclovir hydrolase, putative
Trichomonas vaginalis TVAG_118450   conserved hypothetical protein

Essentiality

Tbg972.4.4450 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu184 Mycobacterium tuberculosis non-essential nmpdr
Tb927.8.8020 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.8020 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.8020 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.8.8020 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.4.4360 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.4360 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.4360 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.4360 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b1410 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Plasmodium falciparum lysophospholipase, putative Compounds References
Plasmodium falciparum lysophospholipase, putative Compounds References
Rattus norvegicus Monoglyceride lipase Compounds References
Homo sapiens monoglyceride lipase Compounds References
Mus musculus monoglyceride lipase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Tbg972.4.4450 (Trypanosoma brucei gambiense), monoglyceride lipase, putative
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