Detailed view for TcCLB.508717.10

Basic information

TDR Targets ID: 54685
Trypanosoma cruzi, tyrosine specific protein phosphatase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.2455 | Length (AA): 668 | MW (Da): 74908 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00102   Protein-tyrosine phosphatase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016791   phosphoric monoester hydrolase activity  
GO:0004725   protein tyrosine phosphatase activity  
GO:0016311   dephosphorylation  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 500 1ygr (A) 610 1139 20.00 0 1 0.93 0.15
55 299 2b49 (A) 665 904 35.00 0 1 0.96 -1.88
4 301 5hde (A) 2 298 29.00 0 1 0.929308 -1.43
8 556 2fh7 (A) 1370 1892 21.00 0 1 1.01276 0.13
31 298 4gfu (A) 26 293 31.00 0 1 0.912098 -1.37
56 293 4az1 (A) 38 284 37.00 0 1 0.841487 -1.35
489 633 4ke2 (A) 25 169 12.00 0 0.01 0.409066 -1.02
498 626 4hji (A) 39 165 14.00 0 0.04 0.353114 -0.63

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_128637)

Species Accession Gene Product
Brugia malayi Bm1_14220   protein-tyrosine phosphatase Lar-like precursor, putative
Caenorhabditis elegans CELE_C09D8.1a   Protein PTP-3, isoform C
Caenorhabditis elegans CELE_C09D8.1   Protein PTP-3, isoform D
Dictyostelium discoideum DDB_G0273817   protein-tyrosine phosphatase 1
Dictyostelium discoideum DDB_G0273097   protein-tyrosine phosphatase 1
Drosophila melanogaster Dmel_CG10443   Leukocyte-antigen-related-like
Echinococcus granulosus EgrG_001133800   receptor type tyrosine protein phosphatase
Echinococcus granulosus EgrG_000058100   receptor type tyrosine protein phosphatase
Echinococcus multilocularis EmuJ_001082700   receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type
Echinococcus multilocularis EmuJ_001149950   Receptor type tyrosine protein phosphatase O
Echinococcus multilocularis EmuJ_000655700   receptor type tyrosine protein phosphatase F
Echinococcus multilocularis EmuJ_001149600   Receptor type tyrosine protein phosphatase O
Echinococcus multilocularis EmuJ_001113400   sortilin receptor
Echinococcus multilocularis EmuJ_001133800   receptor type tyrosine protein phosphatase
Echinococcus multilocularis EmuJ_000058100   receptor type tyrosine protein phosphatase
Echinococcus multilocularis EmuJ_001149500   Receptor type tyrosine protein phosphatase O
Echinococcus multilocularis EmuJ_001149700   Receptor type tyrosine protein phosphatase O
Homo sapiens ENSG00000142949   protein tyrosine phosphatase, receptor type, F
Homo sapiens ENSG00000105426   protein tyrosine phosphatase, receptor type, S
Homo sapiens ENSG00000153707   protein tyrosine phosphatase, receptor type, D
Leishmania braziliensis LbrM.35.5630   tyrosine specific protein phosphatase, putative
Leishmania donovani LdBPK_365610.1   tyrosine specific protein phosphatase, putative
Leishmania infantum LinJ.36.5610   tyrosine specific protein phosphatase, putative
Leishmania major LmjF.36.5370   tyrosine specific protein phosphatase, putative
Leishmania mexicana LmxM.36.5370   tyrosine specific protein phosphatase, putative
Loa Loa (eye worm) LOAG_07061   hypothetical protein
Loa Loa (eye worm) LOAG_07060   hypothetical protein
Loa Loa (eye worm) LOAG_05850   fibronectin type III domain-containing protein
Mus musculus ENSMUSG00000033295   protein tyrosine phosphatase, receptor type, F
Mus musculus ENSMUSG00000028399   protein tyrosine phosphatase, receptor type, D
Mus musculus ENSMUSG00000013236   protein tyrosine phosphatase, receptor type, S
Oryza sativa 4349934   Os11g0180200
Oryza sativa 4351645   Os12g0174800
Onchocerca volvulus OVOC1490  
Schistosoma japonicum Sjp_0064450   Receptor-type tyrosine-protein phosphatase F precursor, putative
Schistosoma japonicum Sjp_0129140   IPR003961,Fibronectin, type III;IPR008957,Fibronectin, type III-like fold,domain-containing
Schistosoma japonicum Sjp_0011030   Receptor-type tyrosine-protein phosphatase S precursor, putative
Schistosoma japonicum Sjp_0011010   Receptor-type tyrosine-protein phosphatase S precursor, putative
Schistosoma japonicum Sjp_0050830   Receptor-type tyrosine-protein phosphatase delta precursor, putative
Schistosoma japonicum Sjp_0027680   Tyrosine-protein phosphatase Lar precursor, putative
Schistosoma japonicum Sjp_0011020   expressed protein
Schistosoma japonicum Sjp_0027670   ko:K06777 protein tyrosine phosphatase, receptor type, D, putative
Schistosoma japonicum Sjp_0011000   ko:K05695 protein tyrosine phosphatase, receptor type, F, putative
Schistosoma mansoni Smp_144050   receptor tyrosine phosphatase type r2a
Schistosoma mansoni Smp_134180   receptor tyrosine phosphatase type r2a
Schistosoma mansoni Smp_130570   receptor tyrosine phosphatase type r2a
Schmidtea mediterranea mk4.000124.13  
Schmidtea mediterranea mk4.013932.01  
Schmidtea mediterranea mk4.000793.09   Receptor tyrosine phosphatase type r2a,putative
Schmidtea mediterranea mk4.009733.00   Tyrosine-protein phosphatase Lar-like
Schmidtea mediterranea mk4.005449.02  
Schmidtea mediterranea mk4.018480.00  
Schmidtea mediterranea mk4.003765.01  
Schmidtea mediterranea mk4.004832.01  
Schmidtea mediterranea mk4.000991.04   Putative receptor tyrosine phosphatase type r2a
Schmidtea mediterranea mk4.008097.00  
Schmidtea mediterranea mk4.013932.00  
Schmidtea mediterranea mk4.003555.02   Tyrosine-protein phosphatase Lar
Schmidtea mediterranea mk4.003765.00  
Schmidtea mediterranea mk4.004832.00  
Schmidtea mediterranea mk4.004193.02  
Schmidtea mediterranea mk4.025888.00  
Trypanosoma cruzi TcCLB.508717.10   tyrosine specific protein phosphatase, putative
Trypanosoma cruzi TcCLB.506839.60   tyrosine specific protein phosphatase, putative

Essentiality

TcCLB.508717.10 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C09D8.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_C09D8.1 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein tyrosine phosphatase, receptor type, D Compounds References
Homo sapiens protein tyrosine phosphatase, receptor type, S Compounds References
Homo sapiens protein tyrosine phosphatase, receptor type, F Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0011 1 1
0.0011 1 0.5
0.0022 0.6061 0.5
0.0011 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

17 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.508717.10 (Trypanosoma cruzi), tyrosine specific protein phosphatase, putative
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