pI: 9.236 |
Length (AA): 428 |
MW (Da): 48004 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 361 | 3n51 (A) | 124 | 486 | 30.00 | 0 | 1 | 1.09606 | 0.2 |
1 | 361 | 3ncg (A) | 148 | 483 | 32.00 | 0 | 1 | 1.10306 | 0.33 |
1 | 196 | 2hw6 (A) | 120 | 334 | 44.00 | 0 | 1 | 0.775544 | -0.15 |
161 | 201 | 5eym (A) | 327 | 367 | 32.00 | 0 | 0.93 | 0.646794 | -1.95 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126600)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G18890 | calcium-dependent protein kinase 1 |
Arabidopsis thaliana | AT2G38910 | calcium-dependent protein kinase 20 |
Arabidopsis thaliana | AT2G35890 | calcium-dependent protein kinase 25 |
Arabidopsis thaliana | AT1G35670 | calcium-dependent protein kinase 2 |
Arabidopsis thaliana | AT4G04710 | calcium-dependent protein kinase 22 |
Arabidopsis thaliana | AT1G50700 | calcium-dependent protein kinase 33 |
Arabidopsis thaliana | AT5G23580 | calcium-dependent protein kinase 12 |
Arabidopsis thaliana | AT5G04870 | calcium dependent protein kinase 1 |
Arabidopsis thaliana | AT1G74740 | calcium-dependent protein kinase 30 |
Arabidopsis thaliana | AT4G04740 | calcium-dependent protein kinase 23 |
Arabidopsis thaliana | AT3G10660 | Ccalcium-dependent protein kinase 2 |
Arabidopsis thaliana | AT3G51850 | calcium-dependent protein kinase 13 |
Arabidopsis thaliana | AT1G61950 | calcium-dependent protein kinase 19 |
Arabidopsis thaliana | AT4G04695 | calcium-dependent protein kinase 31 |
Arabidopsis thaliana | AT5G12480 | calmodulin-domain protein kinase 7 |
Arabidopsis thaliana | AT4G09570 | calcium-dependent protein kinase 4 |
Arabidopsis thaliana | AT4G38230 | calcium-dependent protein kinase 26 |
Arabidopsis thaliana | AT5G12180 | calcium-dependent protein kinase 17 |
Arabidopsis thaliana | AT4G23650 | calcium-dependent protein kinase 6 |
Arabidopsis thaliana | AT4G04720 | calcium-dependent protein kinase 21 |
Arabidopsis thaliana | AT5G19360 | calcium-dependent protein kinase 34 |
Arabidopsis thaliana | AT2G17290 | calcium dependent protein kinase 6 |
Arabidopsis thaliana | AT2G31500 | calcium-dependent protein kinase 24 |
Arabidopsis thaliana | AT4G21940 | calcium-dependent protein kinase 15 |
Arabidopsis thaliana | AT3G57530 | calcium-dependent protein kinase 32 |
Arabidopsis thaliana | AT3G20410 | calmodulin-domain protein kinase 9 |
Arabidopsis thaliana | AT4G35310 | calmodulin-domain protein kinase 5 |
Arabidopsis thaliana | AT4G04700 | calcium-dependent protein kinase 27 |
Arabidopsis thaliana | AT5G19450 | calcium-dependent protein kinase 19 |
Arabidopsis thaliana | AT2G41860 | calcium-dependent protein kinase 14 |
Babesia bovis | BBOV_IV003210 | calcium-dependent protein kinase 4 |
Babesia bovis | BBOV_III005470 | protein kinase domain containing protein |
Brugia malayi | Bm1_37225 | Calcium/calmodulin-dependent protein kinase type II alpha chain |
Brugia malayi | Bm1_31570 | Cam kinase protein 1 |
Candida albicans | CaO19.9323 | Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase |
Candida albicans | CaO19.1754 | Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase |
Caenorhabditis elegans | CELE_K11E8.1 | Protein UNC-43, isoform R |
Caenorhabditis elegans | CELE_K07A9.2 | Protein CMK-1 |
Caenorhabditis elegans | CELE_K11E8.7 | Protein UNC-43, isoform F |
Cryptosporidium hominis | Chro.20118 | CDPK2 |
Cryptosporidium hominis | Chro.50305 | calmodulin-domain protein kinase 1 |
Cryptosporidium hominis | Chro.20142 | calcium-dependent protein kinase |
Cryptosporidium hominis | Chro.30121 | hypothetical protein |
Cryptosporidium parvum | cgd2_1060 | calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands |
Cryptosporidium parvum | cgd5_820 | calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands |
Cryptosporidium parvum | cgd2_1300 | calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands |
Cryptosporidium parvum | cgd3_920 | calmodulin-domain protein kinase 1, putative |
Dictyostelium discoideum | DDB_G0292624 | CAMK1 family protein kinase |
Dictyostelium discoideum | DDB_G0289119 | CAMK1 family protein kinase |
Dictyostelium discoideum | DDB_G0275057 | CAMK1 family protein kinase |
Dictyostelium discoideum | DDB_G0282429 | CAMK1 family protein kinase |
Dictyostelium discoideum | DDB_G0271550 | CAMK1 family protein kinase |
Dictyostelium discoideum | DDB_G0279925 | CAM kinase |
Drosophila melanogaster | Dmel_CG1495 | Calcium/calmodulin-dependent protein kinase I |
Drosophila melanogaster | Dmel_CG18069 | Calcium/calmodulin-dependent protein kinase II |
Echinococcus granulosus | EgrG_000809000 | calcium:calmodulin dependent protein kinase type |
Echinococcus granulosus | EgrG_000595500 | calcium:calmodulin dependent protein kinase type |
Echinococcus granulosus | EgrG_000438300 | calcium dependent protein kinase |
Echinococcus granulosus | EgrG_001083300 | calcium:calmodulin dependent protein kinase type |
Echinococcus granulosus | EgrG_000826600 | calcium:calmodulin dependent protein kinase type 1 |
Entamoeba histolytica | EHI_137980 | protein kinase, putative |
Entamoeba histolytica | EHI_053060 | protein kinase, putative |
Echinococcus multilocularis | EmuJ_001083300 | calcium:calmodulin dependent protein kinase type |
Echinococcus multilocularis | EmuJ_000826600 | calcium:calmodulin dependent protein kinase type |
Echinococcus multilocularis | EmuJ_000595500 | calcium:calmodulin dependent protein kinase type |
Echinococcus multilocularis | EmuJ_000438300 | calcium dependent protein kinase |
Echinococcus multilocularis | EmuJ_000809000 | calcium:calmodulin dependent protein kinase type |
Homo sapiens | ENSG00000145349 | calcium/calmodulin-dependent protein kinase II delta |
Homo sapiens | ENSG00000008118 | calcium/calmodulin-dependent protein kinase IG |
Homo sapiens | ENSG00000148660 | calcium/calmodulin-dependent protein kinase II gamma |
Homo sapiens | ENSG00000058404 | calcium/calmodulin-dependent protein kinase II beta |
Homo sapiens | ENSG00000134072 | calcium/calmodulin-dependent protein kinase I |
Homo sapiens | ENSG00000183049 | calcium/calmodulin-dependent protein kinase ID |
Homo sapiens | ENSG00000130822 | pregnancy up-regulated nonubiquitous CaM kinase |
Homo sapiens | ENSG00000070808 | calcium/calmodulin-dependent protein kinase II alpha |
Homo sapiens | 814 | calcium/calmodulin-dependent protein kinase IV |
Leishmania braziliensis | LbrM.27.2680 | protein kinase, putative |
Leishmania donovani | LdBPK_272420.1 | protein kinase, putative |
Leishmania infantum | LinJ.27.2420 | protein kinase, putative |
Leishmania major | LmjF.27.2470 | protein kinase, putative |
Leishmania mexicana | LmxM.27.2470 | protein kinase, putative |
Loa Loa (eye worm) | LOAG_08089 | calcium/calmodulin-dependent protein kinase ID |
Loa Loa (eye worm) | LOAG_00568 | CAMK/CAMK2 protein kinase |
Loa Loa (eye worm) | LOAG_13538 | hypothetical protein |
Mus musculus | ENSMUSG00000016179 | calcium/calmodulin-dependent protein kinase I gamma |
Mus musculus | ENSMUSG00000002012 | pregnancy upregulated non-ubiquitously expressed CaM kinase |
Mus musculus | ENSMUSG00000021820 | calcium/calmodulin-dependent protein kinase II gamma |
Mus musculus | ENSMUSG00000057897 | calcium/calmodulin-dependent protein kinase II, beta |
Mus musculus | ENSMUSG00000024617 | calcium/calmodulin-dependent protein kinase II alpha |
Mus musculus | ENSMUSG00000030272 | calcium/calmodulin-dependent protein kinase I |
Mus musculus | ENSMUSG00000038128 | calcium/calmodulin-dependent protein kinase IV |
Mus musculus | ENSMUSG00000053819 | calcium/calmodulin-dependent protein kinase II, delta |
Mus musculus | ENSMUSG00000039145 | calcium/calmodulin-dependent protein kinase ID |
Mus musculus | 102642817 | calcium/calmodulin-dependent protein kinase type I-like |
Neospora caninum | NCLIV_070280 | hypothetical protein |
Neospora caninum | NCLIV_017560 | Calcium-dependent protein kinase 2, related |
Neospora caninum | NCLIV_044270 | hypothetical protein |
Neospora caninum | NCLIV_011980 | Calmodulin-like domain protein kinase isoenzyme gamma, related |
Neospora caninum | NCLIV_047750 | hypothetical protein |
Oryza sativa | 4336653 | Os04g0560600 |
Oryza sativa | 4334371 | Os03g0789000 |
Oryza sativa | 4343644 | Os07g0568600 |
Oryza sativa | 4349249 | Os10g0539600 |
Oryza sativa | 4351620 | Os12g0169800 |
Oryza sativa | 4339177 | Os05g0491900 |
Oryza sativa | 4349899 | Os11g0171500 |
Oryza sativa | 4339053 | Os05g0467000 |
Oryza sativa | 4330351 | Os02g0685900 |
Oryza sativa | 4326638 | Os01g0622600 |
Oryza sativa | 4327560 | Os01g0808400 |
Oryza sativa | 4349714 | Os11g0136600 |
Oryza sativa | 9266580 | Os12g0133500 |
Oryza sativa | 4334366 | Os03g0788500 |
Oryza sativa | 4347564 | Os09g0514200 |
Oryza sativa | 4339751 | Os05g0585500 |
Oryza sativa | 4352234 | Os12g0486600 |
Oryza sativa | 4336783 | Os04g0584600 |
Oryza sativa | 4342456 | Os07g0161600 |
Oryza sativa | 4333767 | Os03g0688300 |
Oryza sativa | 4351829 | Os12g0230200 |
Oryza sativa | 4334519 | Os03g0808600 |
Oryza sativa | 4331257 | Os02g0832000 |
Oryza sativa | 4327438 | Os01g0832300 |
Oryza sativa | 4331490 | Os03g0128700 |
Oryza sativa | 4346187 | Os08g0540400 |
Oryza sativa | 4343373 | Os07g0515100 |
Plasmodium berghei | PBANKA_0314200 | calcium-dependent protein kinase 1 |
Plasmodium berghei | PBANKA_0615200 | calcium-dependent protein kinase 4 |
Plasmodium berghei | PBANKA_0408200 | calcium-dependent protein kinase 3 |
Plasmodium berghei | PBANKA_1351500 | calcium-dependent protein kinase 5 |
Plasmodium falciparum | PF3D7_0310100 | calcium-dependent protein kinase 3 |
Plasmodium falciparum | PF3D7_0717500 | calcium-dependent protein kinase 4 |
Plasmodium falciparum | PF3D7_0217500 | calcium-dependent protein kinase 1 |
Plasmodium falciparum | PF3D7_1337800 | calcium-dependent protein kinase 5 |
Plasmodium falciparum | PF3D7_0610600 | calcium-dependent protein kinase 2 |
Plasmodium knowlesi | PKNH_0312500 | calcium-dependent protein kinase 4, putative |
Plasmodium knowlesi | PKNH_0832600 | calcium-dependent protein kinase 3, putative |
Plasmodium knowlesi | PKNH_1263500 | calcium-dependent protein kinase 5, putative |
Plasmodium knowlesi | PKNH_0403400 | calcium-dependent protein kinase 1, putative |
Plasmodium vivax | PVX_119610 | calcium-dependent protein kinase 3, putative |
Plasmodium vivax | PVX_000555 | calcium-dependent protein kinase 4, putative |
Plasmodium vivax | PVX_082820 | calcium-dependent protein kinase, putative |
Plasmodium vivax | PVX_002665 | calcium-dependent protein kinase 1, putative |
Plasmodium yoelii | PY03298 | calmodulin-domain protein kinase |
Plasmodium yoelii | PY02109 | Plasmodium falciparum CDPK2 protein |
Plasmodium yoelii | PY06394 | calcium-dependent protein kinase-3 |
Plasmodium yoelii | PY06527 | calcium-dept. protein kinase |
Saccharomyces cerevisiae | YOL016C | Cmk2p |
Saccharomyces cerevisiae | YFR014C | Cmk1p |
Schistosoma japonicum | Sjp_0121020 | Calcium/calmodulin-dependent protein kinase type II alpha chain, putative |
Schistosoma japonicum | Sjp_0005690 | Calcium/calmodulin-dependent protein kinase type II beta chain, putative |
Schistosoma japonicum | Sjp_0216090 | ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative |
Schistosoma japonicum | Sjp_0049570 | Calcium/calmodulin-dependent protein kinase type 1, putative |
Schistosoma japonicum | Sjp_0308710 | Calcium/calmodulin-dependent protein kinase type II delta chain, putative |
Schistosoma japonicum | Sjp_0049580 | ko:K08794 calcium/calmodulin-dependent protein kinase I, putative |
Schistosoma mansoni | Smp_011660.1 | protein kinase |
Schistosoma mansoni | Smp_011660.3 | protein kinase |
Schistosoma mansoni | Smp_065290 | serine/threonine protein kinase |
Schistosoma mansoni | Smp_011660.2 | protein kinase |
Schmidtea mediterranea | mk4.005994.00 | Putative calcium/calmodulin-dependent protein kinase |
Schmidtea mediterranea | mk4.013326.00 | |
Schmidtea mediterranea | mk4.000319.01 | |
Schmidtea mediterranea | mk4.004587.02 | |
Schmidtea mediterranea | mk4.000319.00 | Calcium/calmodulin-dependent protein kinase type II |
Schmidtea mediterranea | mk4.008112.00 | Calcium/calmodulin-dependent protein kinase type II |
Schmidtea mediterranea | mk4.000395.03 | Calcium/calmodulin-dependent protein kinase type II |
Schmidtea mediterranea | mk4.018615.00 | Calcium/calmodulin-dependent protein kinase type II |
Schmidtea mediterranea | mk4.001941.02 | |
Trypanosoma brucei gambiense | Tbg972.4.3820 | protein kinase, putative |
Trypanosoma brucei | Tb927.4.3770 | calcium/calmodulin-dependent protein kinase, putative |
Trypanosoma congolense | TcIL3000_0_56880 | protein kinase, putative |
Trypanosoma congolense | TcIL3000_0_32980 | protein kinase, putative |
Toxoplasma gondii | TGME49_206590 | calcium-dependent protein kinase CDPK2A |
Toxoplasma gondii | TGME49_305860 | calcium-dependent protein kinase CDPK3 |
Toxoplasma gondii | TGME49_242400 | calcium-dependent protein kinase CDPK2B |
Theileria parva | TP01_1073 | calmodulin-domain protein kinase, putative |
Theileria parva | TP02_0399 | calcium-dependent protein kinase, putative |
Trichomonas vaginalis | TVAG_418720 | CAMK family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.3770 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.3770 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.3770 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.4.3770 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0314200 | Plasmodium berghei | Dispensable | plasmo |
PBANKA_0408200 | Plasmodium berghei | Dispensable | plasmo |
PBANKA_0615200 | Plasmodium berghei | Slow | plasmo |
PBANKA_1351500 | Plasmodium berghei | Essential | plasmo |
TGME49_206590 | Toxoplasma gondii | Probably essential | sidik |
TGME49_305860 | Toxoplasma gondii | Probably essential | sidik |
TGME49_242400 | Toxoplasma gondii | Probably essential | sidik |
TGME49_206590 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_305860 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_242400 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_206590 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_305860 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_242400 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.