Detailed view for TcIL3000_0_43620

Basic information

TDR Targets ID: 552779
Trypanosoma congolense, isocitrate dehydrogenase, putative
Source Database / ID: 

pI: 6.5826 | Length (AA): 230 | MW (Da): 26048 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00180   Isocitrate/isopropylmalate dehydrogenase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016616   oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor  
GO:0004450   isocitrate dehydrogenase (NADP+) activity  
GO:0051287   NAD binding  
GO:0000287   magnesium ion binding  
GO:0055114   oxidation reduction  
GO:0006102   isocitrate metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 230 2qfy (A) 184 411 63.00 0 1 1.7386 -0.5
1 230 4i3l (A) 182 411 61.00 0 1 1.5977 -0.08
1 230 5i95 (A) 221 451 62.00 0 1 1.7493 -0.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127057)

Species Accession Gene Product
Arabidopsis thaliana AT1G54340   isocitrate dehydrogenase
Arabidopsis thaliana AT1G65930   NADP+-dependent isocitrate dehydrogenase
Arabidopsis thaliana AT5G14590   isocitrate dehydrogenase
Babesia bovis BBOV_III007260   isocitrate dehydrogenase, NADP-dependent family protein
Brugia malayi Bm1_48940   isocitrate dehydrogenase
Brugia malayi Bm1_48935   Isocitrate dehydrogenase
Candida albicans CaO19.5211   Mitochondrial NADP-specific isocitrate dehydrogenase
Candida albicans CaO19.3733   cytosolic NADP-specific isocitrate dehydrogenase.
Candida albicans CaO19.11218   N terminus of cytosolic NADP-specific isocitrate dehydrogenase.
Candida albicans CaO19.11217   C terminus of cytosolic NADP-specific isocitrate dehydrogenase.
Candida albicans CaO19.12678   Mitochondrial NADP-specific isocitrate dehydrogenase
Caenorhabditis elegans CELE_C34F6.8   Protein IDH-2
Caenorhabditis elegans CELE_F59B8.2   Protein IDH-1, isoform C
Dictyostelium discoideum DDB_G0272208   isocitrate dehydrogenase (NADP+)
Dictyostelium discoideum DDB_G0272210   isocitrate dehydrogenase (NADP+)
Drosophila melanogaster Dmel_CG7176   Isocitrate dehydrogenase
Echinococcus granulosus EgrG_001068500   NADP dependent isocitrate dehydrogenase
Echinococcus multilocularis EmuJ_000016700   isocitrate dehydrogenase 2 (NADP+)
Echinococcus multilocularis EmuJ_000289300   NADP dependent isocitrate dehydrogenase
Echinococcus multilocularis EmuJ_001068200   NADP dependent isocitrate dehydrogenase
Echinococcus multilocularis EmuJ_001068500   NADP dependent isocitrate dehydrogenase
Echinococcus multilocularis EmuJ_000288600   isocitrate dehydrogenase
Homo sapiens 3418   isocitrate dehydrogenase 2 (NADP+), mitochondrial
Homo sapiens ENSG00000138413   isocitrate dehydrogenase 1 (NADP+), soluble
Leishmania braziliensis LbrM.10.0310   isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
Leishmania donovani LdBPK_100310.1   isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
Leishmania infantum LinJ.10.0310   isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
Leishmania major LmjF.10.0290   isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
Leishmania mexicana LmxM.10.0290   isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
Loa Loa (eye worm) LOAG_10665   isocitrate dehydrogenase
Mus musculus ENSMUSG00000025950   isocitrate dehydrogenase 1 (NADP+), soluble
Mus musculus ENSMUSG00000030541   isocitrate dehydrogenase 2 (NADP+), mitochondrial
Mycobacterium tuberculosis Rv3339c   Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
Neospora caninum NCLIV_039280   Isocitrate dehydrogenase-like protein, related
Neospora caninum NCLIV_056480   hypothetical protein
Oryza sativa 4339674   Os05g0573200
Oryza sativa 4336353   Os04g0508200
Oryza sativa 4324176   Os01g0654500
Oryza sativa 4327213   Os01g0248400
Plasmodium berghei PBANKA_1358600   isocitrate dehydrogenase [NADP], mitochondrial, putative
Plasmodium falciparum PF3D7_1345700   isocitrate dehydrogenase [NADP], mitochondrial
Plasmodium knowlesi PKNH_1255600   isocitrate dehydrogenase [NADP], mitochondrial, putative
Plasmodium vivax PVX_083185   isocitrate dehydrogenase [NADP], mitochondrial, putative
Plasmodium yoelii PY00592   isocitrate dehydrogenase, NADP-dependent
Plasmodium yoelii PY02505   isocitrate dehydrogenase, NADP-dependent, putative
Saccharomyces cerevisiae YLR174W   isocitrate dehydrogenase (NADP(+)) IDP2
Saccharomyces cerevisiae YDL066W   isocitrate dehydrogenase (NADP(+)) IDP1
Saccharomyces cerevisiae YNL009W   isocitrate dehydrogenase (NADP(+)) IDP3
Schistosoma japonicum Sjp_0084670   ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative
Schistosoma mansoni Smp_163050   NADP-specific isocitrate dehydrogenase
Schmidtea mediterranea mk4.008676.00  
Schmidtea mediterranea mk4.003431.11  
Schmidtea mediterranea mk4.003451.03   Isocitrate dehydrogenase
Trypanosoma brucei gambiense Tbg972.11.950   isocitrate dehydrogenase, putative
Trypanosoma brucei gambiense Tbg972.8.3420   isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
Trypanosoma brucei Tb927.8.3690   isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
Trypanosoma brucei Tb927.11.900   isocitrate dehydrogenase, putative
Trypanosoma congolense TcIL3000_0_43620   isocitrate dehydrogenase, putative
Trypanosoma congolense TcIL3000_0_50590   isocitrate dehydrogenase, putative
Trypanosoma cruzi TcCLB.511575.60   isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
Trypanosoma cruzi TcCLB.506925.319   isocitrate dehydrogenase, putative
Toxoplasma gondii TGME49_266760   isocitrate dehydrogenase
Toxoplasma gondii TGME49_313140   isocitrate dehydrogenase
Theileria parva TP04_0620   isocitrate dehydrogenase (NADP+), putative

Essentiality

TcIL3000_0_43620 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3399 Mycobacterium tuberculosis non-essential nmpdr
Tb11.03.0230 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.03.0230 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.03.0230 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.03.0230 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.8.3690 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.3690 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.3690 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.3690 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1358600 Plasmodium berghei Slow plasmo
TGME49_313140 Toxoplasma gondii Probably non-essential sidik
TGME49_266760 Toxoplasma gondii Probably non-essential sidik
TGME49_313140 Toxoplasma gondii Probably essential sidik
TGME49_266760 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcIL3000_0_43620 (Trypanosoma congolense), isocitrate dehydrogenase, putative
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