pI: 7.2682 |
Length (AA): 631 |
MW (Da): 68906 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 13
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 517 | 5nv9 (A) | 8 | 485 | 23.00 | 0 | 0.97 | 1.06013 | -0.22 |
75 | 476 | 2xq2 (A) | 59 | 468 | 27.00 | 0 | 0.53 | 0.838484 | 0.17 |
409 | 553 | 5kte (A) | 177 | 327 | 32.00 | 0.89 | 0.02 | 0.020194 | 2.67 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127635)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_35130 | Sodium:solute symporter family protein |
Caenorhabditis elegans | CELE_F52H2.4 | Protein F52H2.4 |
Caenorhabditis elegans | CELE_ZK822.5 | Protein ZK822.5, isoform B |
Drosophila melanogaster | Dmel_CG10444 | CG10444 gene product from transcript CG10444-RA |
Drosophila melanogaster | Dmel_CG6723 | CG6723 gene product from transcript CG6723-RA |
Drosophila melanogaster | Dmel_CG9657 | CG9657 gene product from transcript CG9657-RB |
Drosophila melanogaster | Dmel_CG32669 | CG32669 gene product from transcript CG32669-RA |
Echinococcus granulosus | EgrG_000636200 | sodium coupled monocarboxylate transporter 1 |
Echinococcus multilocularis | EmuJ_000636200 | sodium coupled monocarboxylate transporter 1 |
Homo sapiens | 160728 | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 |
Homo sapiens | ENSG00000138074 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 |
Homo sapiens | ENSG00000148942 | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 |
Loa Loa (eye worm) | LOAG_05156 | hypothetical protein |
Mus musculus | 241612 | solute carrier family 5 (sodium/glucose cotransporter), member 12 |
Mus musculus | ENSMUSG00000020062 | solute carrier family 5 (iodide transporter), member 8 |
Mus musculus | ENSMUSG00000006641 | solute carrier family 5 (sodium-dependent vitamin transporter), member 6 |
Onchocerca volvulus | OVOC5773 |
|
Schistosoma japonicum | Sjp_0087920 | Sodium-coupled monocarboxylate transporter 1, putative |
Schistosoma japonicum | Sjp_0108820 | ko:K03307 solute:Na+ symporter, SSS family, putative |
Schistosoma japonicum | Sjp_0095080 | Sodium-coupled monocarboxylate transporter 2, putative |
Schistosoma mansoni | Smp_123720 | sodium/solute symporter |
Schmidtea mediterranea | mk4.000785.01 | |
Schmidtea mediterranea | mk4.000709.03 | |
Schmidtea mediterranea | mk4.024776.02 | |
Schmidtea mediterranea | mk4.000785.00 | |
Schmidtea mediterranea | mk4.025896.00 | Sodium-dependent multivitamin transporter |
Schmidtea mediterranea | mk4.000709.00 | |
Schmidtea mediterranea | mk4.024776.00 | Putative sodium/solute symporter |
Schmidtea mediterranea | mk4.000709.02 | |
Schmidtea mediterranea | mk4.013043.01 | |
Schmidtea mediterranea | mk4.017854.00 | Putative sodium/solute symporter |
Schmidtea mediterranea | mk4.021825.00 | |
Schmidtea mediterranea | mk4.026217.02 | Sodium-dependent multivitamin transporter |
Schmidtea mediterranea | mk4.000785.02 | |
Schmidtea mediterranea | mk4.014688.00 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Sodium/iodide cotransporter | 618 aa | 36.0% | 555 aa | Compounds | References |