Detailed view for EgrG_001043400

Basic information

TDR Targets ID: 576108
Echinococcus granulosus, potassium voltage gated channel subfamily KQT
Source Database / ID:  GeneDB

pI: 9.4255 | Length (AA): 99 | MW (Da): 11355 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0008076   voltage-gated potassium channel complex  
GO:0005249   voltage-gated potassium channel activity  
GO:0006813   potassium ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
45 99 2uv4 (A) 254 307 33.00 0.8 0.09 0.731256 1.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129255)

Species Accession Gene Product
Brugia malayi Bm1_25960   Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog
Caenorhabditis elegans CELE_C25B8.1   Protein KQT-1, isoform A
Drosophila melanogaster Dmel_CG33135   KCNQ potassium channel
Echinococcus granulosus EgrG_001043400   potassium voltage gated channel subfamily KQT
Echinococcus granulosus EgrG_001043500   potassium channel KvQLT family member kqt 1
Echinococcus multilocularis EmuJ_001043500   potassium voltage gated channel subfamily KQT
Echinococcus multilocularis EmuJ_001043400   potassium voltage gated channel subfamily KQT
Homo sapiens ENSG00000185760   potassium voltage-gated channel, KQT-like subfamily, member 5
Homo sapiens ENSG00000184156   potassium voltage-gated channel, KQT-like subfamily, member 3
Homo sapiens ENSG00000117013   potassium voltage-gated channel, KQT-like subfamily, member 4
Homo sapiens ENSG00000075043   potassium voltage-gated channel, KQT-like subfamily, member 2
Loa Loa (eye worm) LOAG_12285   potassium voltage-gated channel subfamily Q member 5
Loa Loa (eye worm) LOAG_14106   voltage-gated potassium channel
Loa Loa (eye worm) LOAG_15617   hypothetical protein
Loa Loa (eye worm) LOAG_16114   hypothetical protein
Mus musculus ENSMUSG00000016346   potassium voltage-gated channel, subfamily Q, member 2
Mus musculus ENSMUSG00000028033   potassium voltage-gated channel, subfamily Q, member 5
Mus musculus ENSMUSG00000028631   potassium voltage-gated channel, subfamily Q, member 4
Mus musculus 110862   potassium voltage-gated channel, subfamily Q, member 3
Schistosoma japonicum Sjp_0095320   ko:K05324 potassium voltage-gated channel, KQT-like subfamily, invertebrate, putative
Schistosoma japonicum Sjp_0035900   ko:K04927 potassium voltage-gated channel, KQT-like subfamily, member 2, putative
Schistosoma mansoni Smp_144310   voltage-gated potassium channel KCNQ
Schmidtea mediterranea mk4.021471.00   KQT-1 potassium channel
Schmidtea mediterranea mk4.010324.00  
Schmidtea mediterranea mk4.022918.00   KQT-1 potassium channel
Schmidtea mediterranea mk4.012049.00   KQT-1 potassium channel
Schmidtea mediterranea mk4.025692.00   KQT-1 potassium channel
Schmidtea mediterranea mk4.014253.01  
Schmidtea mediterranea mk4.020704.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens potassium voltage-gated channel, KQT-like subfamily, member 2 Compounds References
Homo sapiens potassium voltage-gated channel, KQT-like subfamily, member 4 Compounds References
Mus musculus potassium voltage-gated channel, subfamily Q, member 2 Compounds References
Rattus norvegicus Potassium voltage-gated channel subfamily KQT member 4 Compounds References
Homo sapiens potassium voltage-gated channel, KQT-like subfamily, member 3 Compounds References
Rattus norvegicus Voltage-gated potassium channel subunit Kv7.2 Compounds References
Homo sapiens potassium voltage-gated channel, KQT-like subfamily, member 5 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1013 0.3747 0.4464
0.0579 0.3361 0.4431
0.1232 0.4451 0.4438
0.0126 0.3451 0.3451
0.096 0.4436 0.4405
0.0142 0.3692 0.3268
0.0197 0.328 0.328
0.0849 0.2587 0.4031
0.1307 0.4405 0.4405
0.0334 0.3847 0.4432
0.0206 0.2614 0.2614
0.0448 0.2589 0.422
0.0283 0.3463 0.4436
0.0078 0.4049 0.391
0.0262 0.428 0
0.0893 0.254 0.4445
0.0078 0.364 0.3308
0.0369 0.3672 0.389
0.0611 0.4339 0.4339
0.0935 0.4211 0.4211
0.0913 0.2686 0
0.1246 0.2849 0.4452
0.184477 0.435468 0.435468
0.0326 0.4422 0.4422
0.1246 0.2849 0.4452
0.0136012 0.381147 0.327403
0.0066 0.3961 0.4095
0.0323 0.3595 0.3595
0.0103 0.3577 0.2496
0.1013 0.3747 0.4464
0.1292 0.4386 0
0.0404 0.4438 0.4438
0.1293 0.4345 0.4345
0.1195 0.4475 0.4475
0.0556 0.3435 0.4405
0.1285 0.4463 0.4463
0.0455 0.4235 0.4221
0.0145 0.4038 0.3991
0.0419 0.2563 0.4389
0.0705 0.4108 0.4108
0.0067 0.3312 0.4152
0.0449 0.4203 0.4203
0.0225754 0.404834 0.404834
0.0078 0.2644 0.4255
0.0442 0.2516 0.2516
0.0928 0.4231 0.4231
0.0323 0.3595 0.3595
0.0526 0.3157 0.4417
0.034 0.279 0.427
0.0368 0.3696 0.3931
0.0333 0.4396 0.4396
0.0365 0.3911 0.3908
0.0274 0.2853 0.2849
0.0078 0.279 0
0.0860552 0.406866 0
0.0348 0.4411 0.4411
0.0264 0.3436 0.3415
0.0141 0.3187 0
0.0576 0.4376 0.4334
0.1391 0.4433 0.4433
0.0318 0.4201 0.4082
0.0262 0.4398 0.4343
0.0394 0.4434 0.4434
0.0998 0.3735 0.4436
0.0313 0.4165 0.4128
0.1475 0.3586 0.448
0.0274 0.4339 0.4164
0.0912 0.4283 0.4283
0.1246 0.2849 0.4452
0.0214 0.3259 0.3259
0.0832 0.4472 0.4472
0.1506 0.4463 0.4435
0.1248 0.4269 0.4268
0.0252 0.2661 0.4401
0.0322 0.4082 0.4082
0.1246 0.2849 0.4452
0.087 0.4141 0.4141
0.1266 0.4417 0.4417
0.0078 0.3821 0.3821
0.1506 0.4463 0.4435
0.0442 0.2516 0.2516
0.0485 0.4006 0.4006
0.0065 0.3011 0.3883
0.1247 0.3543 0.3543
0.029 0.3299 0.4275
0.0204 0.4339 0.4339
0.163 0.4429 0.4424
0.0915 0.4467 0.4465
0.0909 0.4477 0.4477
0.0371 0.3431 0.3431
0.1042 0.4232 0.421
0.0197 0.2629 0.2565
0.0378 0.3648 0
0.0313 0.4165 0.4128
0.0419 0.291 0.289
0.0066 0.3961 0.4095
0.035 0.4134 0.4134
0.0104 0.3574 0.3574
0.0998 0.2848 0.4457
0.1324 0.4418 0.4417
0.0552 0.33 0.4379
0.1071 0.4449 0.4449
0.0323 0.3595 0.3595
0.1276 0.4473 0.4471
0.0673 0.3754 0.4337
0.0714 0.4171 0.4171
0.0787 0.4373 0.4373
0.0286 0.4082 0.4082
0.0704 0.4439 0.4394
0.0229 0.3745 0.4109
0.0974 0.4254 0.4252
0.0927 0.4483 0.4483
0.0274 0.2853 0.2849
0.0434 0.4316 0.4239
0.0114 0.3187 0
0.0141 0.4033 0.2262
0.0628 0.4416 0.4416
0.0078 0.3805 0.4264
0.0134 0.4197 0.4197
0.056 0.4393 0.4393
0.0078 0.2632 0.3496
0.0969 0.283 0.4455
0.0274 0.2882 0.4381
0.0078 0.2599 0.2599
0.1246 0.2849 0.4452
0.1112 0.4346 0.4454
0.0761 0.4446 0.4435
0.1386 0.4446 0.4401
0.064 0.4122 0.4122
0.0467 0.4468 0.4461
0.0502 0.4441 0.4441
0.0064 0.2588 0.3541
0.0652 0.4059 0.3495
0.0646 0.3438 0.4332
0.0338 0.413 0.4094
0.097 0.2783 0.4433
0.0226 0.4176 0.4156
0.0328 0.4352 0.4352
0.033 0.3907 0.3892
0.0448 0.2508 0.4179
0.0209 0.4082 0.4082
0.0317 0.42 0.42
0.0141 0.3438 0
0.0283 0.3463 0.4436
0.0131 0.3065 0
0.1058 0.4048 0.4468
0.0341 0.4391 0.4389
0.0078 0.2972 0.2805
0.1246 0.2849 0.4452
0.0419 0.291 0.289
0.0382 0.3958 0.3943
0.1391 0.4471 0.447
0.0292 0.4082 0.4082
0.0137 0.2792 0.2792
0.0316 0.4383 0.4361
0.0564 0.3467 0.4439
0.1484 0.4487 0.4487
0.0068 0.3194 0.3766
0.0563 0.3431 0.4405
0.0284 0.3465 0.436
0.0349 0.3456 0.3456
0.1307 0.4405 0.4405
0.0826 0.4147 0.4147
0.0136 0.4208 0.4124
0.077 0.4126 0.4109
0.1246 0.2849 0.4452
0.0275 0.4402 0.4402
0.0226 0.4176 0.4156
0.1373 0.43 0.43
0.1506 0.4463 0.4435
0.1345 0.3936 0
0.0064 0.2588 0.3541
0.0535 0.4034 0.4034
0.0974 0.4234 0.4233
0.1246 0.2849 0.4452
0.1297 0.443 0.443
0.0491 0.3925 0.3918
0.0337 0.4356 0.4356
0.0274 0.2882 0.4381
0.0195 0.4307 0.4307
0.1506 0.4463 0.4435
0.113 0.3171 0.4435
0.0277 0.4363 0.4363
0.1313 0.4481 0.448
0.0073 0.3842 0.3842
0.0141 0.4187 0.4187
0.0276 0.302 0.3656
0.0268 0.3993 0.2407
0.0141 0.3386 0.3235
0.231 0.4431 0.4431
0.1324 0.4418 0.4417
0.0369 0.4446 0.4441
0.0648538 0.395332 0
0.0078 0.3671 0.3671
0.1324 0.4418 0.4417
0.1305 0.4405 0.4405
0.0927 0.4212 0.4202
0.0884 0.4432 0.4405
0.0829 0.4126 0.4126
0.0266 0.3728 0.3728
0.1229 0.4473 0.4471
0.0906 0.3644 0.4469
0.0324 0.35 0.35
0.0951 0.2601 0.4455
0.021 0.2546 0.4336
0.0544 0.401 0.3969
0.1246 0.2849 0.4452
0.0277 0.3203 0.3774
0.0601 0.4128 0.4128
0.1246 0.2849 0.4452
0.0075 0.3185 0
0.0753 0.4174 0.4169
0.0267 0.4074 0.4074
0.0953 0.4438 0.443
0.012 0.2675 0.2675
0.0078 0.3271 0.3271
0.0078 0.3821 0.3821
0.0141 0.4135 0.4135
0.0606 0.4383 0.4342
0.0928 0.4256 0.4255
0.0919 0.4483 0.4483
0.0552 0.33 0.4379
0.0133 0.3319 0.3297
0.1055 0.447 0.4442
0.0248 0.3463 0.346
0.1499 0.4319 0.4319
0.1536 0.4489 0.4489
0.0382 0.3958 0.3943
0.0115 0.252 0.2374
0.113 0.2632 0.4456
0.1244 0.4208 0.4208
0.0246 0.2548 0.4357
0.0851 0.4431 0.4431
0.1742 0.4479 0.4479
0.131 0.4299 0.4291
0.034 0.279 0.427
0.0649 0.3846 0.4436
0.1307 0.3589 0.4258
0.1307 0.3589 0.4258
0.1163 0.4086 0
0.1293 0.4345 0.4345
0.1247 0.3543 0.3543
0.0714 0.4171 0.4171
0.098 0.421 0.4199
0.0428 0.3631 0.319
0.048 0.4002 0.3998
0.0323 0.3595 0.3595
0.0663 0.381 0.4405
0.0347 0.4401 0.4397
0.0336 0.3834 0.4351
0.0485 0.4006 0.4006
0.0369 0.4446 0.4441
0.0141 0.4033 0.2262
0.026 0.3833 0.2419
0.021 0.2505 0.4269
0.0078 0.2893 0.2873
0.1391 0.4471 0.447
0.1111 0.4477 0.4475
0.1814 0.4488 0.4488
0.0276 0.302 0.3656
0.0606 0.4428 0.4428
0.0747 0.4134 0.4134
0.0073 0.2829 0.2921
0.1246 0.2849 0.4452
0.0264 0.443 0.443
0.0276 0.3191 0.4322
0.0137 0.4254 0.4254
0.0313 0.3778 0.3778
0.0141 0.3823 0.3823
0.0259 0.2548 0.3702
0.0611 0.4341 0.4341
0.0159 0.4312 0.4254
0.1307 0.4405 0.4405
0.0711 0.4103 0.4101
0.1246 0.2849 0.4452
0.1893 0.4483 0.4482
0.0309 0.2927 0.4317
0.0477 0.4407 0.4405
0.1324 0.4418 0.4417
0.0589 0.3571 0.4089
0.0242 0.3427 0.3427
0.0382 0.3958 0.3943
0.0276 0.3293 0.4304
0.1246 0.2849 0.4452
0.026 0.4288 0.4052
0.1246 0.2849 0.4452
0.0568 0.3469 0.4454
0.1246 0.2849 0.4452
0.0353 0.4401 0.4341
0.0825 0.4201 0.4201
0.0876 0.3404 0.4442
0.0502 0.4441 0.4441
0.0952 0.4235 0.4235
0.0849 0.2587 0.4031
0.0578 0.3399 0.443
0.1246 0.2849 0.4452
0.0404 0.2511 0.4439
0.1146 0.4479 0.4479
0.0063 0.4369 0.4369

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EgrG_001043400 (Echinococcus granulosus), potassium voltage gated channel subfamily KQT
Title for this comment
Comment