Detailed view for EgrG_000157950

Basic information

TDR Targets ID: 576130
Echinococcus granulosus, leucine rich repeat serine:threonine protein
Source Database / ID:  GeneDB

pI: 6.4236 | Length (AA): 3180 | MW (Da): 346849 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00560   Leucine Rich Repeat
PF08477   Ras of Complex, Roc, domain of DAPkinase
PF12799   Leucine Rich repeats (2 copies)
PF16095   C-terminal of Roc, COR, domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 24 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
316 612 4o1p (A) 25 341 16.00 0.000000000086 1 0.168096 0.59
318 441 4rlv (A) 2380 2484 34.00 0.14 1 0.189094 0.62
350 440 1dcq (A) 412 501 24.00 0.00025 1 0.366316 -0.54
365 440 1a5e (A) 56 130 25.00 0.034 0.89 0.308599 0.18
653 735 4xa9 (A) 163 245 18.00 0 0.19 0.224301 -0.49
695 776 5wk4 (D) 69 141 44.00 0.004 0.87 0.400886 -0.16
698 1149 4u08 (A) 71 415 32.00 0.000018 1 0.145238 0.59
700 772 1xku (A) 193 256 42.00 0.97 0.99 0.361056 -0.07
1207 1628 4wnr (A) 307 629 28.00 0.000000042 1 0.0758044 0.69
1220 1433 2f9l (A) 10 178 24.00 0.000071 1 0.0829956 -0.12
1220 1414 2j0v (C) 5 163 19.00 0.012 0.36 -0.166979 0.58
1220 1424 3tw8 (B) 7 176 19.00 0.00034 0.45 0.0771654 -0.24
1221 1629 3dpu (A) 452 781 29.00 0.0098 1 -0.0192836 0.9
1222 1375 2zej (A) 1335 1461 35.00 0.00041 0.38 -0.184472 1.43
1484 1631 3dpt (A) 647 783 25.00 0 1 0.135741 0.11
2269 2646 4wb7 (A) 15 335 18.00 0 1 0.0545679 0.88
2312 2694 5ote (A) 42 395 15.00 0 0.99 0.0281403 1.15
2341 2862 4rer (A) 13 467 17.00 0 1 0.0368509 1.31
2342 2668 1u5q (A) 24 289 23.00 0 1 0.0995302 0.67
2345 2704 3fe3 (A) 55 360 19.00 0 1 0.0679075 0.79
2452 2700 1cm8 (A) 127 327 29.00 0.34 0.54 0.0194019 0.45
2459 2620 5loh (A) 137 796 48.00 0.0054 1 -0.0569566 0.6
2555 2654 5knj (A) 371 464 26.00 0.082 0.72 0.291547 -0.36
2805 2904 4xek (A) 904 1004 17.00 0.037 0.05 0.156147 -0.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131478)

Species Accession Gene Product
Brugia malayi Bm1_27545   Protein kinase domain containing protein
Caenorhabditis elegans CELE_T27C10.6   Protein LRK-1
Dictyostelium discoideum DDB_G0269250   ROCO family protein kinase
Dictyostelium discoideum DDB_G0267472   ROCO family protein kinase
Drosophila melanogaster Dmel_CG5483   Leucine-rich repeat kinase
Echinococcus granulosus EgrG_000157950   leucine rich repeat serine:threonine protein
Echinococcus multilocularis EmuJ_000157950   leucine rich repeat serine:threonine protein
Homo sapiens ENSG00000154237   leucine-rich repeat kinase 1
Homo sapiens ENSG00000188906   leucine-rich repeat kinase 2
Loa Loa (eye worm) LOAG_02500   TKL/LRRK protein kinase
Mus musculus ENSMUSG00000015133   leucine-rich repeat kinase 1
Mus musculus ENSMUSG00000036273   leucine-rich repeat kinase 2
Mus musculus 102641899   leucine-rich repeat serine/threonine-protein kinase 1-like
Schmidtea mediterranea mk4.015658.02   Leucine-rich repeat serine/threonine-protein kinase 2
Schmidtea mediterranea mk4.015658.01   Leucine-rich repeat serine/threonine-protein kinase 2

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens leucine-rich repeat kinase 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0497 0.5013 1
0.0071 0.5065 0.5065
0.0489 0.4953 0.5827
0.0997 0.8931 1
0.0632 0.3242 0.4201
0.0851 0.706 0.706
0.03 0.2966 0.3493
0.0018 0.5 0.5
0.2018 0.2992 0.3128
0.0694 0.2674 0.2673
0.0039 0.9485 0.9402
0.0484 0.5289 0.5289
0.0133 0.3851 0.3851
0.0295 0.3499 0.3474
0.0072 0.2573 0.2573
0.0303 0.5624 0.5624
0.1017 0.7084 0.7084
0.0046 0.2929 0.2611
0.0135 0.3546 0.931
0.0568 0.565 0.5643
0.0117 0.396 0.6165
0.048 0.6858 0.6858
0.1202 0.3775 0.8138
0.0135 0.4464 1
0.0071 0.6392 0.6392
0.2018 0.2992 0.3128
0.0081 1 1
0.0073 0.3786 0.4464
0.0071 0.302 0.302
0.0255 0.8534 0.7749
0.1536 0.3906 0.4277
0.1748 0.9962 0.9962
0.0772 0.9261 0.926
0.0183 0.7978 0.7978
0.0071 0.346 1
0.0717 0.4118 0.4624
0.0027 1 1
0.0247 0.4087 1
0.0160627 0.716619 0.714997
0.0909 0.57 0.7507
0.0688 0.503 0.503
0.0717 0.4118 0.4624
0.0248 0.2841 0.2836
0.0308 0.275 0.2744
0.0235 0.5424 1
0.0129 0.3434 0.6198
0.0036 0.5 0.5
0.0483 0.6566 1
0.0191 0.4213 0.6638
0.0652 0.6786 0.6786
0.0235 0.7705 0.7705
0.0347 0.9072 1
0.0591 0.8026 0.7211
0.0609 0.6195 1
0.0071 0.426 0.5979
0.0667 0.4614 1
0.0646 0.6217 0.6215
0.0696 0.3558 0.4567
0.1 0.3193 0.3669
0.0057 0.3744 1
0.0621 0.4976 1
0.0305 0.8786 1
0.0062 0.6935 0.733
0.1016 0.3182 0.366
0.0007 0.5 0.5
0.2191 0.7321 0.7297
0.0104 0.3741 0.4573
0.0071 0.3313 0.3313
0.0734 0.5449 0.5446
0.114504 0.798439 0.798439
0.0612 0.6471 0.6435
0.0189 0.2885 0.2848
0.0798 0.8268 0.8268
0.0121 0.835 1
0.0081 0.5 0.5
0.0717 0.4118 0.4624
0.0676 0.5038 0.5038
0.0969 0.2769 0.2767
0.0071 0.4614 0.4614
0.0116 0.3959 0.6163
0.0071 0.261 0.4698
0.125351 1 1
0.0612 0.8758 1
0.2018 0.2992 0.3128
0.0071 0.2776 0.7335
0.0175 0.3823 0.3823
0.0008 0.5 0.5
0.0093 0.8828 0
0.139 0.4506 0.4506
0.0026 0.5 0.5
0.1665 0.8779 1
0.1323 0.8001 0.8001
0.0609 0.6179 1
0.0956 0.6534 0.6534
0.0626 0.6865 0.8854
0.0071 0.2714 0.6125
0.0071 0.2804 0.2804
0.0776 0.8089 0.8089
0.0059 0.4863 0.4863
0.0745 0.7575 1
0.2018 0.2992 0.3128
0.1132 0.7739 0.7737
0.0781 0.3863 0.496
0.0072 0.2573 0.2573
0.0751 0.5492 0.5492
0.0071 0.3691 0.3691
0.0117 0.3933 0.6125
0.0835 0.5665 0.5665
0.0252 0.2983 0.298
0.2018 0.2992 0.3128
0.0177 0.8641 0.8641
0.0609 0.6179 1
0.0409 0.893 0.893
0.0628 0.251 1
0.00763188 0.286149 0.286149
0.0071 0.5186 1
0.0088 0.4477 0.4477
0.0367 0.2908 0.732
0.0004 0.5 0.5
0.0187 0.9798 0.979
0.0071 0.6185 0.616
0.0650288 0.444797 0.486911
0.024 0.5565 0.5565
0.1132 0.7739 0.7737
0.0247 0.668 0.6868
0.0997 0.8931 1
0.0853 0.7514 0.7511
0.0781 0.3863 0.496
0.0035 0.3739 1
0.201 0.7085 1
0.0314 0.5462 0.5462
0.0525 0.4158 0.4154
0.1062 0.3831 0.3942
0.0061 0.6883 0.6883
0.0654 0.2563 0.4522
0.0969 0.2769 0.2767
0.0747101 1 1
0.0245 0.4293 0.4293
0.0104 0.3741 0.4573
0.2018 0.2992 0.3128
0.0788 0.9332 0.9332
0.0184 0.6345 1
0.0659 0.6692 0.7878
0.0813 0.483 1
0.1132 0.7739 0.7737
0.0057 0.5074 0.5074
0.1366 0.5054 0.5054
0.0297 0.381 1
0.0071 0.5486 0.7442
0.0791 0.6568 0.6568
0.0738 0.7686 0.7686
0.0311 0.7793 0.7793
0.048 0.6858 0.6858
0.1202 0.3775 0.8138
0.0071 0.4614 0.4614
0.0188 0.7068 0.7065
0.0788 0.9332 0.9332
0.0092 1 1
0.0308 0.275 0.2744
0.2018 0.2992 0.3128
0.0419 0.8831 0.8348
0.0195 0.3664 0.4089
0.0235 0.7705 0.7705
0.0605 0.6108 0.7202
0.0071 0.2574 0.4009
0.0071 0.4309 0.4309
0.2784 0.271 0.7144
0.0193 0.6977 1
0.1665 0.8779 1
0.0769 0.3904 0.5035
0.0788 0.9332 0.9332
0.0059 1 1
0.0071 0.3932 1
0.0072 0.2573 0.2573
0.0183 0.9268 1
0.0577 0.5644 0.5636
0.0056 1 1
0.0058 0.3584 0.3299
0.0164609 0.758536 0.758536
0.0197 0.3718 0.3714
0.2018 0.2992 0.3128
0.0196 0.373 0.373
0.0233 0.3176 0.3176
0.0561 0.5817 0.5817
0.0071 0.5186 1
0.0072 0.2573 0.2573
0.0669 0.9502 0.95
0.0676 0.2777 0.7972
0.0125 0.4578 0.6761
0.0071 0.5243 0.5243
0.0609 0.6195 1
0.0091 1 1
0.0071 0.9285 1
0.057 0.3158 0.2237
0.0257 0.3188 0.6222
0.0643 0.4273 0.6528
0.0066 0.2626 0.2626
0.0795 0.3932 0.3932
0.0298 0.8511 0.8511
0.0037 1 1
0.0309 0.2802 0.2802
0.0519 0.5057 0.5048
0.1223 0.4583 1
0.1187 0.3935 0.4495
0.0039 0.5 0.5
0.0368 0.5244 0.519
0.1128 0.3156 0.3567
0.0831 0.8643 0.8643
0.2018 0.2992 0.3128
0.1076 0.7721 0.7721
0.0371 0.7289 0.7276
0.0071 0.2954 0.753
0.0071 0.2862 1
0.0133 0.4709 1
0.0071 0.2819 1
0.0071 0.6874 0.6874
0.0071 0.3326 0.4678
0.0655 0.258 0.258
0.0288 0.7971 0
0.076 0.3936 0.5081
0.2018 0.2992 0.3128
0.0033 1 1
0.0117 0.3933 0.6125
0.0058 0.2772 0.2772
0.0071 0.2557 0.2557
0.0621 0.2502 1
0.0063 0.2965 1
0.0057 0.2557 0.2557
0.0032 0.5 0.5
0.0311 0.7793 0.7793
0.0237 0.6605 0.8387
0.1788 0.3479 0.3477
0.085 0.7187 0.7186
0.012 0.2825 1
0.0504 0.5117 1
0.0071 0.2899 0.2899
0.085 0.7187 0.7186
0.0676 0.2777 0.7972
0.0071 0.2557 0.2557
0.0003 0.5 0.5
0.0071 0.2829 0.333
0.0665 0.5711 0.5711
0.0064 0.2973 1
0.0545 0.638 0.7529
0.0913 0.7518 0.7517
0.0072 0.2573 0.2573
0.0023 0.5 0.5
0.0909 0.57 0.7507
0.0655 0.258 0.258
0.0338 0.4234 0.4231
0.0193 0.6977 1
0.0012 0.5 0.5
0.105 0.4947 0.4947
0.0621 0.4976 1
0.1132 0.7739 0.7737
0.0768 0.3881 0.5012
0.0368 0.5244 0.519
0.0348 0.3776 1
0.0357 0.3908 1
0.0072 0.2573 0.2573
0.0676 0.2777 0.7972
0.0012 0.5 0.5
0.0195 0.3664 0.4089
0.0795 0.3932 0.3932
0.0071 0.6332 0.6332
0.1665 0.8779 1
0.1032 0.5912 0.6861
0.0292 0.5329 0.5311
0.0538 0.7875 0.7875
0.0858 0.8872 0.8872
0.0299 0.2972 0.3499
0.0298 0.3837 1
0.0059 1 1
0.0072 0.2573 0.2573
0.0626 0.6865 0.8854
0.0855 0.6943 0.6943
0.0173 0.4733 0.79
0.0071 0.4944 1
0.0789 0.6021 0.602
0.0646 0.6451 0.6451
0.0743 0.7535 1
0.0768 0.3881 0.5012
0.0619 0.458 0.458
0.0016 0.5 0.5
0.0189 0.2503 0.4795
0.0117 0.3937 0.6129
0.0135 0.4464 1
0.0665 0.7245 0.7245
0.0072 0.2573 0.2573
0.1748 0.9962 0.9962
0.0042 0.5 0.5
0.0748 0.5371 0.5371
0.0163912 0.731637 0.730101
0.0063 0.7244 0
0.0066 0.3101 0.7874
0.1665 0.8779 1
0.0256 0.4786 1
0.1366 0.5054 0.5054
0.0609 0.6179 1
0.024 0.642 1
0.0127 0.3869 0.6695
0.00767514 1 1
0.0997 0.8931 1
0.1665 0.8779 1
0.0133 0.7947 1
0.0357 0.3908 1
0.0601 0.3863 0.7258
0.0645 0.652 1
0.0189 0.3705 0.7952
0.0063 0.3985 0.3985
0.0298 0.8511 0.8511
0.0491 0.5815 0.5815
0.0248 0.5748 1
0.0359 0.3268 0.3265
0.012 0.3771 0.591
0.0577 0.5644 0.5636
0.0191 0.9275 0.9275
0.2018 0.2992 0.3128
0.0597 0.6154 0.4471
0.0133 0.3038 0.3038
0.0497 0.5013 1
0.0072 0.2573 0.2573
0.0098 0.3242 0.2282
0.071 0.498 0.498
0.0071 0.2626 0.2626
0.0135 0.4464 1
0.1414 0.2523 0.7586
0.0811 0.2593 0.2981
0.0071 0.6561 0.6561
0.0717 0.4118 0.4624
0.0007 0.5 0.5
0.2302 0.938 1
0.0071 0.3221 0.3221
0.0353 0.2721 0.2667
0.0654 0.2563 0.4522
0.063 0.3781 0.3781
0.0071 0.2893 0.2893
0.0071 0.3919 1
0.0806 0.8786 0.8816
0.0659 0.6692 0.7878
0.0308 0.275 0.2744
0.0724 0.3846 0.4467
0.0061 0.7826 0.7826
0.1062 0.3375 0.3869
0.2018 0.2992 0.3128
0.1085 0.2638 0.3712
0.0231 0.2827 0.3566
0.0849 0.875 0.875
0.0368 0.5244 0.519
0.0072 0.2573 0.2573
0.0622 0.3079 0.3079
0.0909 0.57 0.7507
0.3535 0.575 0.8892
0.0124 0.2557 0.2557
0.0063 1 1
0.0654 0.2563 0.4522
0.1078 0.563 0.6454
0.0544 0.9736 0.9736
0.0022 0.5 0.5
0.0341 0.3362 0.3362
0.0032 0.5 0.5
0.0046 0.2836 0.9673
0.0643 0.4273 0.6528
0.2018 0.2992 0.3128
0.0033 0.5 0.5
0.0488 0.3336 0.4704
0.2115 0.2794 1
0.1665 0.8779 1
0.0532 0.6687 0.7863
0.0869 0.7123 0.7123
0.0479 0.4843 0.4843
0.0813 0.6806 0.6794
0.0235 0.2503 1
0.063 0.3781 0.3781
0.0071 0.8119 0.8116
0.0597 0.6051 0.6182
0.0717 0.4118 0.4624
0.0069 0.3067 0.3067
0.1536 0.3906 0.4277
0.0016 0.5 0.5
0.0717 0.4118 0.4624
0.2302 0.938 1
0.0057 0.2626 0.2626
0.0059 1 1
0.0235 0.2957 0.313
0.013 0.8323 0.8323
0.0484 0.3729 0.3729
0.063 0.3781 0.3781
0.1605 0.404 0.404
0.0488 0.3329 0.4704
0.0071 0.2992 0.2992
0.105 0.4947 0.4947
0.08 0.9591 0.9591
0.0126 0.2817 0.7572
0.0886 0.5794 1
0.1165 0.9291 0.9291
0.0338 0.4234 0.4231
0.0071 0.2557 0.2557
0.0059 0.4863 0.4863
0.0691 0.3559 0.4568
0.0576 0.6852 0.6849
0.0117 0.5187 0.5215
0.0652 0.6786 0.6786
0.0411 0.2602 0.5635
0.047 0.9442 0.9442
0.0312 0.2926 0.6197
0.0646 0.6217 0.6215
0.0748 0.5371 0.5371
0.0768 0.3881 0.5012
0.0741 0.8886 0.8886
0.0938 0.5034 0.65
0.0133 0.3851 0.3851
0.1026 0.9978 0.9978
0.0067 0.5 0.5
0.0072 0.265 0.2635
0.0944 0.2975 0.3422
0.0435 0.499 0.5851
0.0012 0.5 0.5
0.0423 0.8554 0.8543
0.0029 0.5 0.5
0.0643 0.4273 0.6528
0.0115 0.3799 0.3799
0.0007 0.5 0.5
0.0073 0.3284 0.3284
0.0622 0.3079 0.3079
0.0255 0.8534 0.7749
0.0727 0.8417 0.8417
0.0483 0.8454 1
0.0969 0.2769 0.2767
0.0629 0.3267 0.4227
0.0886 0.5794 1
0.0116 0.3085 0.3143
0.0953 0.6548 0.6548
0.0297 0.4695 0.5914
0.0573 0.5658 0.565
0.0011 1 1
0.0064 0.2852 0.2852
0.0253 0.2559 1
0.0189 0.2885 0.2848
0.2018 0.2992 0.3128
0.0064 0.3377 0.5563
0.0071 0.312 0.312
0.2191 0.7321 0.7297
0.1122 0.3212 0.3604
0.0552 0.5774 1
0.0071 0.8278 0.8278
0.0688 0.357 0.4582
0.0488 0.5813 0.5809
0.0039 0.5 0.5
0.0597 0.8544 0.8523
0.0997 0.8931 1
0.0126 0.2817 0.7572
0.1353 0.2682 1
0.0072 0.2573 0.2573
0.1132 0.7739 0.7737
0.0104 0.3741 0.4573
0.1202 0.3775 0.8138

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EgrG_000157950 (Echinococcus granulosus), leucine rich repeat serine:threonine protein
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