Detailed view for EgrG_000441900

Basic information

TDR Targets ID: 579388
Echinococcus granulosus, synaptic vesicle 2 protein
Source Database / ID:  GeneDB

pI: 6.3313 | Length (AA): 513 | MW (Da): 56048 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 9

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00083   Sugar (and other) transporter
PF07690   Major Facilitator Superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0022857   transmembrane transporter activity  
GO:0016021   integral to membrane  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
36 491 4zw9 (A) 11 466 15.00 0 0.56 0.988489 -0.07
50 198 3wdo (A) 22 173 32.00 0.0061 0.89 0.551648 0.52
83 203 6ei3 (A) 71 195 34.00 0.38 0.16 0.177067 1.99
271 476 2onk (C) 39 247 23.00 0.64 0.09 0.268759 1.56

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127756)

Species Accession Gene Product
Arabidopsis thaliana AT3G13050   nicotinate transporter
Candida albicans CaO19.6592   potential transporter similar to S. pombe SPAPB1E7.08c
Caenorhabditis elegans CELE_ZK637.1   Protein SVOP-1
Drosophila melanogaster Dmel_CG4324   CG4324 gene product from transcript CG4324-RC
Echinococcus granulosus EgrG_000441900   synaptic vesicle 2 protein
Echinococcus multilocularis EmuJ_000441900   synaptic vesicle 2 protein
Homo sapiens 55530   SV2 related protein homolog (rat)
Mus musculus ENSMUSG00000042078   SV2 related protein
Oryza sativa 4347844   Os09g0559800
Oryza sativa 9271195   Os04g0609200
Oryza sativa 4333528   Os03g0638200
Oryza sativa 4343669   Os07g0571700
Schistosoma japonicum Sjp_0105540   Synaptic vesicle 2-related protein, putative
Schistosoma mansoni Smp_171870   sugar transporter
Schmidtea mediterranea mk4.019901.00   Putative transporter SVOPL
Schmidtea mediterranea mk4.031880.00   Putative transporter SVOPL

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0661 0.3105 0.3068
0.0882 0.383 0.3798
0.0693 0.2676 0
0.0919 0.4066 0.4066
0.0604 0.5795 0.5795
0.0801 0.3587 0.3587
0.0785 0.3546 0.3447
0.0955 0.3879 0.3879
0.0954 0.378 0.378
0.0822 0.3544 0.3492
0.0152 0.339 0.3348
0.0859 0.3676 0.3676
0.0801 0.5193 0.5191
0.0911 0.3937 0.3937
0.0862 0.3709 0.3709
0.0808 0.3589 0.3589
0.0859 0.3889 0.3889
0.0909 0.3804 0.3793
0.0006 0.5 0.5
0.0786 0.3708 0.3708
0.0086 0.5 0.5
0.0026 0.4542 0.4542
0.0757 0.2571 0.3379
0.0778 0.2723 0.2579
0.0888 0.4111 0.4111
0.0692 0.2863 0
0.0759 0.7344 0.7192
0.0863 0.3613 0.3613
0.0699 0.3137 0.3133
0.0878 0.4008 0.4008
0.0872 0.3682 0.3662
0.0701 0.6657 0.6657
0.0891 0.3748 0.3748
0.0856 0.3829 0.3829
0.0852 0.3669 0.3669
0.0898 0.388 0.3842
0.09 0.368 0.368
0.0832 0.3853 0.3853
0.088 0.3774 0.3774
0.0104 0.4448 1
0.0911 0.3866 0.3866
0.0808 0.7747 0.7742
0.0565 0.513 0.513
0.0779 0.2877 0.75
0.0847 0.3728 0.3728
0.0006 0.5 0.5
0.0919 0.3894 0.3872
0.0883 0.4017 0.4017
0.0932 0.3859 0.3859
0.0801 0.5193 0.5191
0.0242 1 1
0.0869 0.3805 0.3805
0.0019 0.3675 0.3675
0.0861 0.3665 0.3665
0.0703 0.282 0
0.0784 0.766 0.766
0.0933 0.3903 0.3881
0.0912 0.3836 0.3836
0.0725 0.3007 0
0.0851 0.3655 0
0.0852 0.3794 0.3794
0.0676 0.4278 0.427
0.0681 0.282 0
0.0778 0.2723 0.2579
0.0115 0.8254 1
0.0902 0.384 0.369
0.0849 0.3822 0.3822
0.0808 0.3589 0.3589
0.0904 0.385 0.385
0.0906 0.4211 0.4211
0.0855 0.4048 0.4048
0.0746 0.2979 0.2675
0.0372 0.3723 1
0.0886 0.3725 0.3725
0.092 0.3639 0.3639
0.0737 0.7131 0.7131
0.0785 0.7428 0.7315
0.0934 0.3952 0.3952
0.0802 0.3726 0.3726
0.0684 0.661 0.6604
0.089 0.2727 0.42
0.0708 0.6913 0.6911
0.0026 0.2589 0.2589
0.0006 0.5 0.5
0.0744 0.3371 0.3351
0.0938 0.3795 0.3795
0.0902 0.3872 0.3725
0.0805 0.3768 0.3766
0.0072 0.5 0.5
0.0808 0.4976 0.4976
0.0905 0.392 0.392
0.0636 0.5945 0.5936
0.0943 0.4376 0.4376
0.0924 0.363 0.363
0.0782 0.3584 0.3584
0.0766 0.3381 0.3381
0.0016 0.5 0.5
0.0858 0.401 0.401
0.0778 0.2723 0.2579
0.0875 0.4019 0.4019
0.0893 0.3833 0.3833
0.0006 0.5 0.5
0.0906 0.3653 0.3653
0.0881 0.4196 0.4196
0.038 0.5 0.5
0.0902 0.3808 0.3788
0.0731 0.7159 0.7158
0.0872 0.3879 0.3879
0.0913 0.4084 0.4084
0.0836 0.4016 0.3997
0.0578 0.5 0.5
0.0858 0.3951 0.3951
0.0789 0.351 0.351
0.0947 0.3919 0.3919
0.0731 0.6098 0.6098
0.0916 0.4286 0.4286
0.0945 0.3769 0.3769
0.0931 0.3822 0.3822
0.0851 0.3655 0
0.0006 0.5 0.5
0.0931 0.4131 0.4131
0.0801 0.3419 0.3419
0.0967 0.3866 0.3866
0.0859 0.3771 0.3771
0.0934 0.355 0.4262
0.0866 0.3965 0.3965
0.0705 0.2788 0
0.001 0.5 0.5
0.0602 0.2622 0.2622
0.0006 0.5 0.5
0.0885 0.3952 0.3952
0.0052 0.3137 0.4731
0.0854 0.368 0.368
0.0215 1 1
0.0901 0.3833 0.3807
0.0006 0.5 0.5
0.0395 0.4327 0.4318
0.0662 0.6327 0.6128
0.0006 0.5 0.5
0.0766 0.3381 0.3381
0.0937 0.3983 0.3955
0.0124 0.5 0.5
0.0731 0.7159 0.7158
0.0824 0.7893 0.7793
0.0906 0.4211 0.4211
0.0218 0.2749 0.2735
0.0676 0.4278 0.427
0.0006 0.5 0.5
0.0788 0.3469 0.3469
0.0848 0.3654 0.3533
0.0779 0.7604 0.7604
0.0835 0.7944 0.7854
0.0006 0.5 0.5
0.0879 0.3794 0.3794
0.086 0.4118 0.4095
0.0891 0.4065 0.4065
0.0828 0.3611 0.3597
0.0701 0.6673 0.6673
0.0785 0.3546 0.3447
0.0869 0.3613 0
0.0443 0.5 0.5
0.0026 0.5 0.5
0.0614 0.4905 0.4896
0.082 0.3993 0.3993
0.0838 0.798 0.789
0.0017 0.5 0.5
0.0887 0.3854 0.3824
0.0825 0.381 0.381
0.0006 0.5 0.5
0.0885 0.38 0.38
0.0676 0.4278 0.427
0.0846 0.3834 0.3834
0.0933 0.3971 0.3964
0.0867 0.3611 0.3611
0.0693 0.3086 0.3086
0.0705 0.673 0.673
0.0815 0.3701 0.3682
0.0904 0.3997 0.3997
0.0814 0.3388 0
0.0917 0.76 0.76
0.0771 0.3215 0
0.0788 0.3469 0.3469
0.0761 0.7227 0.7214
0.0906 0.3708 0.3708
0.0026 0.5 0.5
0.0811 0.3835 0.3835
0.0473 0.4582 0
0.0746 0.2979 0.2675
0.0778 0.2723 0.2579
0.09 0.3856 0.3856
0.0115 0.8254 1
0.0856 0.3899 0.3899
0.0877 0.3703 0.3685
0.0691 0.6563 0.6563
0.0904 0.388 0.3849
0.0931 0.4131 0.4131
0.08 0.3562 0.3562
0.0839 0.3687 0.3687
0.0825 0.395 0.395
0.0908 0.4056 0.4055
0.0855 0.3965 0.3965
0.0649 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier EgrG_000441900 (Echinococcus granulosus), synaptic vesicle 2 protein
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