Detailed view for EgrG_000471600

Basic information

TDR Targets ID: 589872
Echinococcus granulosus, transitional endoplasmic reticulum atpase
Source Database / ID:  GeneDB

pI: 5.1897 | Length (AA): 796 | MW (Da): 88046 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00004   ATPase family associated with various cellular activities (AAA)
PF02359   Cell division protein 48 (CDC48), N-terminal domain
PF02933   Cell division protein 48 (CDC48), domain 2
PF09336   Vps4 C terminal oligomerisation domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0016787   hydrolase activity  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 180 4rv0 (A) 17 182 63.00 0 1 0.993743 -1.31
19 761 5c18 (A) 24 769 87.00 0 1 1.94832 -0.83
642 695 3aji (B) 337 390 30.00 0.54 0.94 0.599739 -1.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126926)

Species Accession Gene Product
Arabidopsis thaliana AT3G09840   cell division control protein 48-A
Arabidopsis thaliana AT5G03340   cell division control protein 48C
Arabidopsis thaliana AT3G53230   cell division control protein 48-B
Babesia bovis BBOV_IV008360   cell division control protein 48, putative
Babesia bovis BBOV_IV001700   cell division cycle protein ATPase, putative
Brugia malayi Bm1_55480   transitional endoplasmic reticulum ATPase TER94, putative
Candida albicans CaO19.2340   microsomal protein of CDC48 family of ATPases
Candida albicans CaO19.9876   microsomal protein of CDC48 family of ATPases
Caenorhabditis elegans CELE_C41C4.8   Protein CDC-48.2
Caenorhabditis elegans CELE_C06A1.1   Protein CDC-48.1
Cryptosporidium hominis Chro.10043   cell division cycle protein 48
Cryptosporidium parvum cgd1_330   CDC48 like AAA ATPase ortholog
Dictyostelium discoideum DDB_G0288065   CDC48 family AAA ATPase
Drosophila melanogaster Dmel_CG2331   CG2331 gene product from transcript CG2331-RA
Echinococcus granulosus EgrG_000471600   transitional endoplasmic reticulum atpase
Entamoeba histolytica EHI_045120   transitional endoplasmic reticulum ATPase, putative
Entamoeba histolytica EHI_176970   cdc48-like protein, putative
Echinococcus multilocularis EmuJ_000471600   transitional endoplasmic reticulum atpase
Echinococcus multilocularis EmuJ_000471200   transitional endoplasmic reticulum atpase
Giardia lamblia GL50803_16867   AAA family ATPase
Homo sapiens ENSG00000165280   valosin containing protein
Leishmania braziliensis LbrM.35.1490   Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog
Leishmania donovani LdBPK_361420.1   Valosin-containing protein, putative
Leishmania infantum LinJ.36.1420   Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog
Leishmania major LmjF.36.1370   Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog
Leishmania mexicana LmxM.36.1370   Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog
Loa Loa (eye worm) LOAG_12115   VCP protein
Mus musculus ENSMUSG00000028452   valosin containing protein
Mycobacterium tuberculosis Rv0435c   Putative conserved ATPase
Mycobacterium ulcerans MUL_1384   ATPase
Neospora caninum NCLIV_034460   hypothetical protein
Neospora caninum NCLIV_004280   hypothetical protein
Oryza sativa 4345563   Os08g0413000
Oryza sativa 4331645   Os03g0151800
Onchocerca volvulus OVOC10958   Transitional endoplasmic reticulum ATPase homolog
Plasmodium berghei PBANKA_1118600   cell division cycle protein 48 homologue, putative
Plasmodium falciparum PF3D7_0619400   cell division cycle protein 48 homologue, putative
Plasmodium knowlesi PKNH_1131000   cell division cycle protein 48 homologue, putative
Plasmodium vivax PVX_088085   cell division cycle ATPase, putative
Plasmodium vivax PVX_114095   cell division cycle protein 48 homologue, putative
Plasmodium yoelii PY03639   cell division cycle protein 48 homolog
Saccharomyces cerevisiae YDL126C   AAA family ATPase CDC48
Schistosoma japonicum Sjp_0085890   ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative
Schistosoma japonicum Sjp_0119040   Transitional endoplasmic reticulum ATPase homolog 2, putative
Schistosoma mansoni Smp_018240.1   cell division control protein 48 aaa family protein
Schistosoma mansoni Smp_018240.3   cell division control protein 48 aaa family protein
Schistosoma mansoni Smp_018240.4   cell division control protein 48 aaa family protein
Schmidtea mediterranea mk4.000105.16  
Schmidtea mediterranea mk4.001497.01   Transitional endoplasmic reticulum ATPase
Schmidtea mediterranea mk4.003445.02   Transitional endoplasmic reticulum ATPase
Schmidtea mediterranea mk4.001265.01   Transitional endoplasmic reticulum ATPase
Schmidtea mediterranea mk4.001265.00  
Schmidtea mediterranea mk4.000565.09   Transitional endoplasmic reticulum ATPase
Schmidtea mediterranea mk4.000727.02   Transitional endoplasmic reticulum ATPase
Trypanosoma brucei gambiense Tbg972.10.7000   valosin-containing protein homolog,Transitional endoplasmic reticulum ATPase, putative
Trypanosoma brucei Tb927.10.5770   Valosin-containing protein
Trypanosoma congolense TcIL3000_10_4820   Valosin-containing protein, putative
Trypanosoma cruzi TcCLB.509733.170   Valosin-containing protein, putative
Toxoplasma gondii TGME49_321640   cell division protein CDC48AP
Toxoplasma gondii TGME49_273090   cell division protein CDC48CY
Toxoplasma gondii TGME49_324300   transitional endoplasmic reticulum ATPase, putative
Theileria parva TP01_0937   cell division cycle protein 48, putative
Theileria parva TP03_0490   cell division cycle protein 48, putative
Trichomonas vaginalis TVAG_318870   spermatogenesis associated factor, putative

Essentiality

EgrG_000471600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.5770 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.5770 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.5770 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.5770 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C06A1.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_C06A1.1 Caenorhabditis elegans larval lethal wormbase
CELE_C06A1.1 Caenorhabditis elegans slow growth wormbase
CELE_C06A1.1 Caenorhabditis elegans sterile wormbase
CELE_C41C4.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_C41C4.8 Caenorhabditis elegans larval arrest wormbase
CELE_C41C4.8 Caenorhabditis elegans larval lethal wormbase
CELE_C41C4.8 Caenorhabditis elegans slow growth wormbase
CELE_C41C4.8 Caenorhabditis elegans sterile wormbase
YDL126C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1118600 Plasmodium berghei Essential plasmo
TGME49_321640 Toxoplasma gondii Probably essential sidik
TGME49_273090 Toxoplasma gondii Probably essential sidik
TGME49_324300 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens valosin containing protein Compounds References
Mus musculus valosin containing protein Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.00208016 0.727943 0.718476
0.0395 0.3941 1
0.0605 0.7106 0.7106
0.1397 0.2669 0.4611
0.0034 0.3767 0
0.0856 0.8734 0.935
0.0374 0.3718 0.5429
0.0643 0.8456 0.8451
0.0034 0.3206 0
0.1101 0.2704 0.4837
0.066 0.3454 0.3454
0.0411 0.4083 0.4077
0.0502 0.5977 0.5973
0.0034 0.3168 0
0.0791 0.9667 1
0.0034 0.8066 0
0.0423 0.5119 0.5715
0.0395 0.4509 0.5775
0.0034 0.3822 0
0.063 0.6249 1
0.0791 0.9671 1
0.066 0.3454 0.3454
0.0166 0.6406 0.6244
0.0643 0.8456 0.8451
0.0408 0.5832 0.5832
0.0058 0.9426 0.5
0.0263 0.3038 0.3027
0.0255 0.2989 0.721
0.0284 0.6115 0.6111
0.1386 0.6393 1
0.0395 0.4509 0.5775
0.0778 0.3703 0.6753
0.0409 0.8671 1
0.1512 0.7901 1
0.0034 0.5527 0.5097
0.0643 0.8456 0.8451
0.123 0.4069 0.4069
0.0454 0.6905 0.6905
0.0714 0.8531 0.8516
0.0395 0.3941 1
0.0856 0.8734 0.935
0.0142 0.2643 0.2643
0.0343 0.4995 0.4995
0.0062 0.3428 0
0.0571 0.5857 1
0.0444 0.4479 0.6327
0.0352 0.5083 0.5083
0.0349 0.9892 1
0.0061 0.2907 0.2946
0.02 0.2768 0.2786
0.0083 0.286 0.2264
0.0338 0.3994 0.3982
0.0493 0.6269 0.6261
0.0606 0.727 1
0.0407 0.536 0.536
0.0465 0.5657 1
0.0061 0.2907 0.2946
0.0225 0.8017 0.7258
0.006 0.335 0.3408
0.0832 0.6132 0.6132
0.0832 0.6132 0.6132
0.0169 0.5423 0.5423
0.0493 0.6269 0.6261
0.0625 0.254 0.3828
0.0406 0.3913 0.39
0.0929 0.5207 0.5
0.0031 0.5527 0.5097
0.0524 0.5249 1
0.006 0.3436 0.3436
0.0403 0.5291 1
0.0034 0.4525 1
0.0027 0.3368 0.1998
0.0741 0.9436 1
0.0058 0.667 0
0.0029 0.5527 0.5097
0.0688 0.4919 0.4919
0.0034 0.8148 0
0.1041 0.6095 0.6095
0.0275 0.5861 0
0.0571 0.5857 1
0.0458 0.2528 0.108
0.0059 0.4246 0.4246
0.012 0.4525 1
0.0084 0.275 1
0.0849 0.8642 1
0.0028 0.3457 0.3211
0.0571 0.5857 1
0.0348 0.3579 0.5
0.0267 0.5664 0
0.0118 0.3191 0.2462
0.0316 0.8579 1
0.0029 0.3425 0
0.0861 0.8772 1
0.0290695 0.378129 0.378129
0.063 0.6249 1
0.123 0.4069 0.4069
0.0594 0.3352 0.3352
0.0034 0.3176 0
0.1416 0.3145 1
0.0118 0.3013 0.2813
0.0407 0.536 0.536
0.0675 0.5013 0.4732
0.0503 0.2775 0.5204
0.0292 0.8213 1
0.0741 0.9436 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier EgrG_000471600 (Echinococcus granulosus), transitional endoplasmic reticulum atpase
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