Detailed view for EgrG_000061400

Basic information

TDR Targets ID: 590980
Echinococcus granulosus, agrin
Source Database / ID:  GeneDB

pI: 7.6476 | Length (AA): 1680 | MW (Da): 184825 | Paralog Number: 0

Signal peptide: N | GPI Anchor: Y | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00050   Kazal-type serine protease inhibitor domain
PF00053   Laminin EGF domain
PF02210   Laminin G domain
PF07648   Kazal-type serine protease inhibitor domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

ECM-receptor interaction (KEGG)

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
373 591 3hh2 (C) 87 288 40.00 0 1 0.327957 1.23
387 426 1uvg (A) 23 62 40.00 0.033 0.47 0.53041 -0.69
614 652 5dae (A) 5 36 59.00 0.0042 0.72 0.387814 0.78
797 832 4z81 (A) 523 553 45.00 0.52 0.88 0.483029 -0.93
1098 1129 5l0v (B) 8 37 53.00 0.022 1 0.620648 -0.41
1098 1131 5mwb (A) 425 456 47.00 0.053 1 0.545838 -0.25
1100 1131 5ky4 (B) 974 1003 57.00 0.19 1 0.389648 0.8
1487 1669 1pz7 (A) 11 192 26.00 0.0054 1 0.292529 -0.33
1574 1673 2r16 (A) 790 897 31.00 0.28 0.41 0.118124 1.93

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129460)

Species Accession Gene Product
Brugia malayi Bm1_54935   Kazal-type serine protease inhibitor domain containing protein
Brugia malayi Bm1_43325   Kazal-type serine protease inhibitor domain containing protein
Caenorhabditis elegans CELE_F29G6.1   Protein F29G6.1
Caenorhabditis elegans CELE_F41G3.12   Protein AGR-1
Cryptosporidium hominis Chro.40405   T13C2.5
Cryptosporidium hominis Chro.40094   hypothetical protein
Cryptosporidium parvum cgd4_750   extracellular protein with a signal peptide and 8 kazal repeats
Cryptosporidium parvum cgd4_3550   secreted protein with signal peptide and 12 KAZAL repeats and a mucin-like stretch of threonines
Dictyostelium discoideum DDB_G0283705   hypothetical protein
Drosophila melanogaster Dmel_CG32354   CG32354 gene product from transcript CG32354-RA
Echinococcus granulosus EgrG_000061400   agrin
Echinococcus multilocularis EmuJ_000061400   agrin
Homo sapiens ENSG00000188157   agrin
Loa Loa (eye worm) LOAG_11977   agrin synaptic family protein
Loa Loa (eye worm) LOAG_10354   hypothetical protein
Loa Loa (eye worm) LOAG_08663   kazal-type serine protease inhibitor domain-containing protein
Loa Loa (eye worm) LOAG_12370   hypothetical protein
Loa Loa (eye worm) LOAG_12970   hypothetical protein
Mus musculus ENSMUSG00000041936   agrin
Neospora caninum NCLIV_027000   serine protease inhibitor dipetalogastin precursor, putative
Onchocerca volvulus OVOC12272  
Schistosoma japonicum Sjp_0090530   hypothetical protein
Schistosoma japonicum Sjp_0002300   ko:K06254 agrin, putative
Schistosoma mansoni Smp_155050   agrin
Schmidtea mediterranea mk4.000244.08  
Schmidtea mediterranea mk4.000244.09   AGRin
Schmidtea mediterranea mk4.004859.01   AGRin
Schmidtea mediterranea mk4.004859.00  
Toxoplasma gondii TGME49_266610   Kazal-type serine protease inhibitor domain-containing protein
Toxoplasma gondii TGME49_259890   Kazal-type serine protease inhibitor domain-containing protein

Essentiality

EgrG_000061400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F29G6.1 Caenorhabditis elegans embryonic lethal wormbase
TGME49_266610 Toxoplasma gondii Probably non-essential sidik
TGME49_259890 Toxoplasma gondii Probably non-essential sidik
TGME49_266610 Toxoplasma gondii Essentiality uncertain sidik
TGME49_259890 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0019 0.6332 0.6332
0.0031 0.6236 0.568
0.0204 0.2522 0.2969
0.0021 0.6032 0.6032
0.0043 0.2638 0.2557
0.0037 0.6098 0.6098
0.0039 0.4244 0.4244
0.0044 0.6345 0.6345
0.0046 0.6613 0.6613
0.00360767 0.473735 0.473735
0.0124 0.6525 0.6525
0.0088 0.6526 0.6526
0.0078 0.279 0.2876
0.0082 0.4632 0.4632
0.0045 0.6345 0.6345
0.0046 0.6345 0.6345
0.0043 0.4401 0
0.0124 0.3878 0.4485
0.0019 0.4701 0.4701
0.0042 0.6098 0.6098
0.0038 0.3496 0.357
0.0141 0.6566 0.6566
0.0029 0.593 0
0.0174 0.5172 0.5172
0.0041 0.4329 0.4329
0.0046 0.569 0.569
0.0088 0.6526 0.6526
0.0085 0.4705 0.4705
0.0157 0.5655 0.6514
0.0039 0.45 0.45
0.0294 0.6742 0.6732
0.0022 0.6032 0.6032
0.004 0.2638 0.2557
0.0019 0.4788 0.4788
0.002 0.5954 0.5954
0.0038 0.3496 0.357
0.0046 0.4902 0.4902
0.0078 0.3044 0.3002
0.0042 0.3354 0
0.0019 0.4701 0.4701
0.0082 0.5327 0.5179
0.018894 0.613271 0.613271
0.0038 0.4084 0.4084
0.00710515 0.264443 0.264443
0.0116 0.4656 0.4646
0.0044 0.6345 0.6345

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EgrG_000061400 (Echinococcus granulosus), agrin
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