Detailed view for EgrG_000994100

Basic information

TDR Targets ID: 591912
Echinococcus granulosus, solute carrier family 22
Source Database / ID:  GeneDB

pI: 7.871 | Length (AA): 540 | MW (Da): 59678 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 9

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00083   Sugar (and other) transporter

Gene Ontology

Mouse over links to read term descriptions.
GO:0022857   transmembrane transporter activity  
GO:0016021   integral to membrane  
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
65 126 1wib (A) 0 53 41.00 0.32 0.12 0.259115 1.31
191 325 5x51 (A) 1045 1176 30.00 0.63 0.08 -0.0117 3.43
191 513 3wdo (A) 47 384 17.00 0 0.43 0.614648 0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129524)

Species Accession Gene Product
Arabidopsis thaliana AT3G20660   organic cation/carnitine transporter4
Brugia malayi Bm1_38360   major facilitator superfamily protein
Brugia malayi Bm1_05050   hypothetical protein
Caenorhabditis elegans CELE_Y82E9BR.16   Protein Y82E9BR.16, isoform B
Caenorhabditis elegans CELE_F52F12.1   Protein OCT-1, isoform B
Drosophila melanogaster Dmel_CG13610   Organic cation transporter 2
Drosophila melanogaster Dmel_CG6331   Organic cation transporter
Escherichia coli b2771   putative transporter
Echinococcus granulosus EgrG_001099600   solute carrier family 22
Echinococcus granulosus EgrG_000994100   solute carrier family 22
Echinococcus granulosus EgrG_001058900   solute carrier family 22
Echinococcus granulosus EgrG_000957000   solute carrier family 22
Echinococcus multilocularis EmuJ_001099600   solute carrier family 22
Echinococcus multilocularis EmuJ_001058900   solute carrier family 22
Echinococcus multilocularis EmuJ_000994100   solute carrier family 22
Echinococcus multilocularis EmuJ_000957000   solute carrier family 22
Homo sapiens ENSG00000197375   solute carrier family 22 (organic cation/carnitine transporter), member 5
Homo sapiens ENSG00000197208   solute carrier family 22 (organic cation/zwitterion transporter), member 4
Loa Loa (eye worm) LOAG_13863   hypothetical protein
Loa Loa (eye worm) LOAG_15676   hypothetical protein
Loa Loa (eye worm) LOAG_13134   hypothetical protein
Loa Loa (eye worm) LOAG_06361   hypothetical protein
Mus musculus ENSMUSG00000018900   solute carrier family 22 (organic cation transporter), member 5
Mus musculus ENSMUSG00000063652   solute carrier family 22 (organic cation transporter), member 21
Mus musculus ENSMUSG00000020334   solute carrier family 22 (organic cation transporter), member 4
Oryza sativa 4337103   Os04g0631100
Onchocerca volvulus OVOC4694  
Schistosoma japonicum Sjp_0092960   ko:K08202 MFS transporter, OCT family, solute carrier family 22 (organic, putative
Schistosoma japonicum Sjp_0092970   ko:K08208 MFS transporter, OCT family, solute carrier family 22 (organic, putative
Schistosoma mansoni Smp_129540   sugar transporter
Schistosoma mansoni Smp_013640   sugar transporter
Schmidtea mediterranea mk4.006707.01  
Schmidtea mediterranea mk4.006266.02  
Schmidtea mediterranea mk4.003506.04  
Schmidtea mediterranea mk4.001320.01  
Schmidtea mediterranea mk4.000202.07  
Schmidtea mediterranea mk4.001320.02  
Schmidtea mediterranea mk4.000667.00  

Essentiality

EgrG_000994100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2771 Escherichia coli non-essential goodall
CELE_Y82E9BR.16 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y82E9BR.16 Caenorhabditis elegans larval arrest wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0152 0.339 0.3348
0.0954 0.378 0.378
0.0822 0.3544 0.3492
0.0859 0.3676 0.3676
0.0801 0.3587 0.3587
0.0955 0.3879 0.3879
0.0785 0.3546 0.3447
0.0693 0.2676 0
0.0882 0.383 0.3798
0.0661 0.3105 0.3068
0.0919 0.4066 0.4066
0.0604 0.5795 0.5795
0.0757 0.2571 0.3379
0.0026 0.4542 0.4542
0.0086 0.5 0.5
0.0006 0.5 0.5
0.0786 0.3708 0.3708
0.0911 0.3937 0.3937
0.0801 0.5193 0.5191
0.0909 0.3804 0.3793
0.0808 0.3589 0.3589
0.0859 0.3889 0.3889
0.0862 0.3709 0.3709
0.0891 0.3748 0.3748
0.0852 0.3669 0.3669
0.0856 0.3829 0.3829
0.0701 0.6657 0.6657
0.0872 0.3682 0.3662
0.0759 0.7344 0.7192
0.0863 0.3613 0.3613
0.0878 0.4008 0.4008
0.0699 0.3137 0.3133
0.0778 0.2723 0.2579
0.0888 0.4111 0.4111
0.0692 0.2863 0
0.0006 0.5 0.5
0.0847 0.3728 0.3728
0.0883 0.4017 0.4017
0.0919 0.3894 0.3872
0.0808 0.7747 0.7742
0.0779 0.2877 0.75
0.0565 0.513 0.513
0.0104 0.4448 1
0.0911 0.3866 0.3866
0.09 0.368 0.368
0.0832 0.3853 0.3853
0.0898 0.388 0.3842
0.088 0.3774 0.3774
0.0784 0.766 0.766
0.0703 0.282 0
0.0861 0.3665 0.3665
0.0933 0.3903 0.3881
0.0019 0.3675 0.3675
0.0869 0.3805 0.3805
0.0242 1 1
0.0801 0.5193 0.5191
0.0932 0.3859 0.3859
0.0904 0.385 0.385
0.0906 0.4211 0.4211
0.0849 0.3822 0.3822
0.0808 0.3589 0.3589
0.0115 0.8254 1
0.0681 0.282 0
0.0778 0.2723 0.2579
0.0902 0.384 0.369
0.0851 0.3655 0
0.0725 0.3007 0
0.0912 0.3836 0.3836
0.0676 0.4278 0.427
0.0852 0.3794 0.3794
0.0785 0.7428 0.7315
0.0737 0.7131 0.7131
0.092 0.3639 0.3639
0.0886 0.3725 0.3725
0.0746 0.2979 0.2675
0.0372 0.3723 1
0.0855 0.4048 0.4048
0.0072 0.5 0.5
0.0905 0.392 0.392
0.0808 0.4976 0.4976
0.0902 0.3872 0.3725
0.0938 0.3795 0.3795
0.0805 0.3768 0.3766
0.0006 0.5 0.5
0.0026 0.2589 0.2589
0.0708 0.6913 0.6911
0.0744 0.3371 0.3351
0.0684 0.661 0.6604
0.0802 0.3726 0.3726
0.0934 0.3952 0.3952
0.089 0.2727 0.42
0.0875 0.4019 0.4019
0.0778 0.2723 0.2579
0.0858 0.401 0.401
0.0782 0.3584 0.3584
0.0924 0.363 0.363
0.0766 0.3381 0.3381
0.0016 0.5 0.5
0.0943 0.4376 0.4376
0.0636 0.5945 0.5936
0.0913 0.4084 0.4084
0.0578 0.5 0.5
0.0836 0.4016 0.3997
0.0731 0.7159 0.7158
0.0902 0.3808 0.3788
0.0872 0.3879 0.3879
0.0006 0.5 0.5
0.038 0.5 0.5
0.0881 0.4196 0.4196
0.0906 0.3653 0.3653
0.0893 0.3833 0.3833
0.0851 0.3655 0
0.0006 0.5 0.5
0.0789 0.351 0.351
0.0858 0.3951 0.3951
0.0916 0.4286 0.4286
0.0945 0.3769 0.3769
0.0931 0.3822 0.3822
0.0947 0.3919 0.3919
0.0731 0.6098 0.6098
0.0052 0.3137 0.4731
0.0854 0.368 0.368
0.0602 0.2622 0.2622
0.0006 0.5 0.5
0.001 0.5 0.5
0.0885 0.3952 0.3952
0.0866 0.3965 0.3965
0.0705 0.2788 0
0.0801 0.3419 0.3419
0.0967 0.3866 0.3866
0.0931 0.4131 0.4131
0.0934 0.355 0.4262
0.0859 0.3771 0.3771
0.0779 0.7604 0.7604
0.0848 0.3654 0.3533
0.0788 0.3469 0.3469
0.0676 0.4278 0.427
0.0006 0.5 0.5
0.0879 0.3794 0.3794
0.0006 0.5 0.5
0.0835 0.7944 0.7854
0.0906 0.4211 0.4211
0.0824 0.7893 0.7793
0.0218 0.2749 0.2735
0.0937 0.3983 0.3955
0.0766 0.3381 0.3381
0.0662 0.6327 0.6128
0.0006 0.5 0.5
0.0731 0.7159 0.7158
0.0124 0.5 0.5
0.0215 1 1
0.0901 0.3833 0.3807
0.0006 0.5 0.5
0.0395 0.4327 0.4318
0.0614 0.4905 0.4896
0.0869 0.3613 0
0.0443 0.5 0.5
0.0785 0.3546 0.3447
0.0026 0.5 0.5
0.0701 0.6673 0.6673
0.0828 0.3611 0.3597
0.0891 0.4065 0.4065
0.086 0.4118 0.4095
0.0917 0.76 0.76
0.0906 0.3708 0.3708
0.0771 0.3215 0
0.0761 0.7227 0.7214
0.0788 0.3469 0.3469
0.0705 0.673 0.673
0.0693 0.3086 0.3086
0.0814 0.3388 0
0.0904 0.3997 0.3997
0.0815 0.3701 0.3682
0.0867 0.3611 0.3611
0.0846 0.3834 0.3834
0.0676 0.4278 0.427
0.0885 0.38 0.38
0.082 0.3993 0.3993
0.0017 0.5 0.5
0.0887 0.3854 0.3824
0.0838 0.798 0.789
0.0825 0.381 0.381
0.0006 0.5 0.5
0.0933 0.3971 0.3964
0.0931 0.4131 0.4131
0.08 0.3562 0.3562
0.0839 0.3687 0.3687
0.0904 0.388 0.3849
0.0649 0.5 0.5
0.0825 0.395 0.395
0.0908 0.4056 0.4055
0.0855 0.3965 0.3965
0.0691 0.6563 0.6563
0.0877 0.3703 0.3685
0.0856 0.3899 0.3899
0.0473 0.4582 0
0.0746 0.2979 0.2675
0.0115 0.8254 1
0.09 0.3856 0.3856
0.0778 0.2723 0.2579
0.0026 0.5 0.5
0.0811 0.3835 0.3835

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier EgrG_000994100 (Echinococcus granulosus), solute carrier family 22
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