Detailed view for EgrG_000814400

Basic information

TDR Targets ID: 592539
Echinococcus granulosus, subfamily M14A unassigned peptidase
Source Database / ID:  GeneDB

pI: 9.8577 | Length (AA): 420 | MW (Da): 48177 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00246   Zinc carboxypeptidase
PF02244   Carboxypeptidase activation peptide

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0004181   metallocarboxypeptidase activity  
GO:0004180   carboxypeptidase activity  
GO:0006508   proteolysis  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
21 420 2boa (A) 4 1305 27.00 0 1 1.32498 -0.65
22 420 1aye (A) 5 305 32.00 0 1 1.4051 -0.89
120 418 1m4l (A) 2 303 35.00 0 1 1.21 -1.01
124 419 5mrv (A) 23 324 37.00 0 1 1.20636 -0.84
126 418 2c1c (A) 7 303 35.00 0 1 1.18072 -1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128876)

Species Accession Gene Product
Brugia malayi Bm1_43230   Zinc carboxypeptidase family protein
Candida albicans CaO19.299   potential zinc carboxypeptidase similar to S. cerevisiae ECM14
Candida albicans CaO19.7931   potential zinc carboxypeptidase similar to S. cerevisiae ECM14
Caenorhabditis elegans CELE_T06A4.1   Protein T06A4.1, isoform B
Caenorhabditis elegans CELE_Y59C2A.1   Protein Y59C2A.1
Caenorhabditis elegans CELE_ZC434.9   Protein ZC434.9, isoform E
Drosophila melanogaster Dmel_CG12374   CG12374 gene product from transcript CG12374-RA
Drosophila melanogaster Dmel_CG3108   CG3108 gene product from transcript CG3108-RA
Drosophila melanogaster Dmel_CG3097   CG3097 gene product from transcript CG3097-RA
Echinococcus granulosus EgrG_000814400   subfamily M14A unassigned peptidase
Echinococcus multilocularis EmuJ_000814400   subfamily M14A unassigned peptidase
Homo sapiens ENSG00000158516   carboxypeptidase A2 (pancreatic)
Homo sapiens ENSG00000128510   carboxypeptidase A4
Loa Loa (eye worm) LOAG_13783   hypothetical protein
Loa Loa (eye worm) LOAG_01994   hypothetical protein
Mus musculus ENSMUSG00000039070   carboxypeptidase A4
Mus musculus ENSMUSG00000071553   carboxypeptidase A2, pancreatic
Onchocerca volvulus OVOC10498   Subfamily M14A unassigned peptidase homolog
Onchocerca volvulus OVOC1211  
Saccharomyces cerevisiae YHR132C   Ecm14p
Schistosoma japonicum Sjp_0200870   ko:K01290 carboxypeptidase A [EC3.4.17.1], putative
Schistosoma mansoni Smp_088270   subfamily M14A unassigned peptidase (M14 family)
Schmidtea mediterranea mk4.012413.00  
Schmidtea mediterranea mk4.019093.00   Subfamily M14A unassigned peptidase
Schmidtea mediterranea mk4.014591.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Carboxypeptidase A1 419 aa 32.3% 403 aa Compounds References
Sus scrofa Carboxypeptidase B 416 aa 28.7% 418 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1371 0.7951 1
0.0508 0.4382 0.946
0.0255 0.2884 0.3564
0.1371 0.7951 1
0.0508 0.4382 0.946
0.0426 0.5169 0.5169
0.0405 0.3397 0.5567
0.0055 0.4963 1
0.0068 0.8051 0
0.1054 0.2931 0.8459
0.0493 0.3178 1
0.00458364 1 0.5
0.0264 0.3274 0.6585
0.0247 0.2745 0.349
0.0148 0.4298 0.4298
0.0488 0.9045 1
0.0068 0.8341 0.9297
0.0118 0.4395 0.5
0.0724 0.7342 1
0.0727 0.3598 0.3576
0.0124 0.4662 0.5
0.0426 0.5169 0.5169
0.0343 0.2855 0.4713
0.0115 0.2988 0.3716
0.0327 0.5167 1
0.0445 0.7734 1
0.0344 0.4343 0.8676
0.0233 0.7853 0.7853
0.0247 0.2745 0.349
0.0378 0.7952 1
0.07142 1 1
0.1371 0.7951 1
0.0587 0.2599 0.2591
0.0121 0.2568 0.2302
0.0698 0.5936 0.5936
0.1371 0.7951 1
0.1371 0.7951 1
0.0344 0.3226 0.3818
0.0331 0.9651 1
0.0374 0.6819 0.7372
0.0723 0.6232 0.8599
0.0723 0.6232 0.8599
0.0374 0.4555 0.6176
0.0426 0.5169 0.5169
0.0235 0.3312 0.3905
0.0442 0.2652 0.4881
0.0115 0.2988 0.3716
0.2256 0.7621 0.7621
0.0426 0.5169 0.5169
0.1371 0.7951 1
0.0056 0.3639 1
0.0136 0.3761 0.3679
0.0068 0.3555 0.3555
0.0637 0.3814 1
0.0172 0.2562 0
0.0146 0.2825 0.5
0.0587 0.2599 0.2591
0.0442 0.2652 0.4881
0.1371 0.7951 1
0.0115 0.2988 0.3716
0.038 0.6714 1
0.0068 0.7836 0
0.0386 0.4553 1
0.0488 0.9045 1
0.0068 0.2736 0
0.0426 0.5169 0.5169
0.0148 0.2938 0.2938
0.1054 0.2931 0.8459
0.034 0.3795 0.6427
0.0638 0.8036 0.8032
0.0607 0.3426 1
0.0723 0.6232 0.8599
0.0488 0.9045 1
0.024 0.8645 1
0.0488 0.9045 1
0.0587 0.2599 0.2591
0.0493 0.3178 1
0.00480833 1 0.5
0.0107 0.3733 0.4812
0.0159 0.302 0.302
0.0327 0.3204 0.8739
0.0457 0.26 0.6667
0.0701 0.8841 1
0.0374 0.6819 0.7372
0.1172 0.6697 0.6697
0.0068 0.3501 0
0.0426 0.5169 0.5169
0.0403 0.344 1
0.0121 0.4521 0.5
0.024 0.9956 0.995
0.0233 0.7853 0.7853
0.1371 0.7951 1
0.1054 0.2931 0.8459
0.0124 0.661 1
0.0344 0.9339 0.9329
0.0052 0.2731 0
0.0344 0.6106 1
0.0488 0.9045 1
0.0611 0.3443 1
0.0353 0.5699 0.5699
0.0239 0.299 0.2897
0.0343 0.2854 0.4713
0.1172 0.6696 0.6695
0.0285 0.4744 1
0.0136 0.7487 0.7487
0.0173 0.2723 0.4676
0.0727 0.3598 0.3576
0.0723 0.6232 0.8599
0.0488 0.9045 1
0.0124 0.4662 0.5
0.0123 0.4332 0
0.0701 0.8841 1
0.0733 0.2704 0.2766
0.0108 0.7425 0.7425
0.064 0.3096 0.3091
0.1234 0.3488 1
0.0409 0.4788 0.7536
0.0343 0.6191 0.6682
0.0426 0.5169 0.5169
0.064 0.3096 0.3091
0.0508 0.4382 0.946
0.0409 0.423 0.4714
0.0476 0.5352 0.9773
0.1054 0.2931 0.8459
0.1323 0.865 1
0.0729 0.5148 0.4936
0.00480833 1 0.5
0.0488 0.9045 1
0.0109 0.3599 1
0.0068 0.8051 0
0.0698 0.5936 0.5936
0.0638 0.8036 0.8032

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EgrG_000814400 (Echinococcus granulosus), subfamily M14A unassigned peptidase
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