Detailed view for EgrG_001054000

Basic information

TDR Targets ID: 593194
Echinococcus granulosus, fibrillin 2
Source Database / ID:  GeneDB

pI: 7.7642 | Length (AA): 535 | MW (Da): 59000 | Paralog Number: 9

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07645   Calcium-binding EGF domain
PF07974   EGF-like domain
PF12661   Human growth factor-like EGF

Gene Ontology

Mouse over links to read term descriptions.
GO:0005509   calcium ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
23 321 4xbm (B) 178 439 33.00 0 1 0.357478 2.03
94 135 3a7q (A) 2474 2512 49.00 0.0038 1 0.656105 -0.76
202 232 5l0v (B) 1 31 52.00 0.27 0.87 0.656544 -0.7
483 515 5l0v (B) 5 37 27.00 0.00093 0.76 0.285982 0.51
489 520 5jb9 (E) 95 126 28.00 0.49 0.48 0.194113 1.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126814)

Species Accession Gene Product
Echinococcus granulosus EgrG_000961800   nuclear pore complex protein Nup107
Echinococcus granulosus EgrG_001054000   fibrillin 2
Echinococcus granulosus EgrG_000264700   hypothetical protein
Echinococcus granulosus EgrG_000248900   gag pol polyprotein
Echinococcus granulosus EgrG_000943300   G patch domain containing 1
Echinococcus granulosus EgrG_000466300   oligopeptidase
Echinococcus granulosus EgrG_000616800   ubiquitin conjugating enzyme
Echinococcus granulosus EgrG_001087700   60s ribosomal protein l7
Echinococcus granulosus EgrG_000717100   myelin proteolipid
Echinococcus granulosus EgrG_000961700   Ubiquitin associated translation elongation factor EF1B
Echinococcus multilocularis EmuJ_000943300   G patch domain containing 1
Echinococcus multilocularis EmuJ_000264700   hypothetical protein
Echinococcus multilocularis EmuJ_000466300   oligopeptidase
Echinococcus multilocularis EmuJ_001087700   60s ribosomal protein l7
Echinococcus multilocularis EmuJ_000248900   gag pol polyprotein
Echinococcus multilocularis EmuJ_000717100   myelin proteolipid
Echinococcus multilocularis EmuJ_001054000   fibrillin 2
Echinococcus multilocularis EmuJ_000961800   nuclear pore complex protein Nup107
Echinococcus multilocularis EmuJ_000616800   ubiquitin conjugating enzyme
Schistosoma japonicum Sjp_0112000   IPR000449,Ubiquitin-associated;IPR009060,UBA-like,domain-containing
Schistosoma japonicum Sjp_0219350   IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing
Schistosoma japonicum Sjp_0107140   IPR006209,EGF-like;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR013032,EGF-like region,domain-containing
Schistosoma japonicum Sjp_0053130   Latent-transforming growth factor beta-binding protein, isoform 1L precursor, putative
Schistosoma japonicum Sjp_0079620   ko:K10704 ubiquitin-conjugating enzyme E2 variant, putative
Schistosoma japonicum Sjp_0002790   Transposon Ty3-G Gag-Pol polyprotein, putative
Schistosoma japonicum Sjp_0067380   Pol polyprotein [Contains: Reverse transcriptase/ribonuclease H, putative
Schistosoma japonicum Sjp_0022040   IPR001567,Peptidase M3A and M3B, thimet/oligopeptidase F,domain-containing
Schistosoma japonicum Sjp_0041960   IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing
Schistosoma japonicum Sjp_0028390   expressed protein
Schistosoma japonicum Sjp_0109290   hypothetical protein
Schistosoma japonicum Sjp_0304250   Conserved hypothetical protein
Schistosoma japonicum Sjp_0077680   60S ribosomal protein L7, putative
Schistosoma japonicum Sjp_0096990   expressed protein
Schistosoma japonicum Sjp_0053140   Nuclear pore complex protein Nup107, putative
Schistosoma japonicum Sjp_0116540   IPR001584,Integrase, catalytic region;IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing
Schistosoma japonicum Sjp_0305910   IPR013032,EGF-like region;IPR013111,EGF, extracellular;IPR006210,EGF,domain-containing
Schistosoma japonicum Sjp_0209680   expressed protein
Schistosoma japonicum Sjp_0022670   IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing
Schistosoma japonicum Sjp_0057410   ko:K09555 BCL2-associated athanogene 1, putative
Schistosoma japonicum Sjp_0076900   hypothetical protein
Schistosoma japonicum Sjp_0089180   G patch domain-containing protein 1, putative
Schistosoma japonicum Sjp_0008720   Retrovirus-related Pol polyprotein from transposon opus [Includes: Protease, putative
Schistosoma japonicum Sjp_0311600   Nuclear pore complex protein Nup107, putative
Schistosoma japonicum Sjp_0032020   IPR006209,EGF-like;IPR013032,EGF-like region,domain-containing
Schistosoma japonicum Sjp_0037060   Conserved hypothetical protein
Schistosoma japonicum Sjp_0219230   similar to Retrotransposable element Tf2 155 kDa protein type 3, putative
Schistosoma mansoni Smp_114740   hypothetical protein
Schistosoma mansoni Smp_192540   hypothetical protein
Schistosoma mansoni Smp_157030   hypothetical protein
Schistosoma mansoni Smp_193940   hypothetical protein
Schistosoma mansoni Smp_194500   hypothetical protein
Schistosoma mansoni Smp_183030   hypothetical protein
Schistosoma mansoni Smp_100790   hypothetical protein
Schistosoma mansoni Smp_190300   hypothetical protein
Schistosoma mansoni Smp_124790   hypothetical protein
Schistosoma mansoni Smp_124550   hypothetical protein
Schistosoma mansoni Smp_138820   hypothetical protein
Schistosoma mansoni Smp_122190   hypothetical protein
Schistosoma mansoni Smp_135810   hypothetical protein
Schistosoma mansoni Smp_164460   hypothetical protein
Schistosoma mansoni Smp_124400   hypothetical protein
Schistosoma mansoni Smp_132960   hypothetical protein
Schistosoma mansoni Smp_175380   hypothetical protein
Schistosoma mansoni Smp_132570   choline/ethanolamine kinase
Schistosoma mansoni Smp_190450   hypothetical protein
Schistosoma mansoni Smp_122320   hypothetical protein
Schistosoma mansoni Smp_049790   hypothetical protein
Schistosoma mansoni Smp_107670   hypothetical protein
Schistosoma mansoni Smp_061930   hypothetical protein
Schistosoma mansoni Smp_189480   hypothetical protein
Schistosoma mansoni Smp_001085   gag-pol protein
Schistosoma mansoni Smp_130150   hypothetical protein
Schistosoma mansoni Smp_127260   hypothetical protein
Schistosoma mansoni Smp_117360   hypothetical protein
Schistosoma mansoni Smp_163390   hypothetical protein
Schistosoma mansoni Smp_177070   hypothetical protein
Schistosoma mansoni Smp_190710   hypothetical protein
Schistosoma mansoni Smp_127820   hypothetical protein
Schistosoma mansoni Smp_137290   hypothetical protein
Schistosoma mansoni Smp_135410   hypothetical protein
Schistosoma mansoni Smp_174560   hypothetical protein
Schistosoma mansoni Smp_130720   hypothetical protein
Schistosoma mansoni Smp_189980   hypothetical protein
Schistosoma mansoni Smp_175350   hypothetical protein
Schistosoma mansoni Smp_185870   hypothetical protein
Schistosoma mansoni Smp_132110   hypothetical protein
Schistosoma mansoni Smp_173950   hypothetical protein
Schistosoma mansoni Smp_165450   hypothetical protein
Schistosoma mansoni Smp_184840   hypothetical protein
Schistosoma mansoni Smp_166810   hypothetical protein
Schistosoma mansoni Smp_049800   hypothetical protein
Schistosoma mansoni Smp_162950   hypothetical protein
Schistosoma mansoni Smp_118790   hypothetical protein
Schistosoma mansoni Smp_132650   hypothetical protein
Schistosoma mansoni Smp_150000   hypothetical protein
Schistosoma mansoni Smp_004540   hypothetical protein
Schistosoma mansoni Smp_131920   hypothetical protein
Schistosoma mansoni Smp_107430   hypothetical protein
Schistosoma mansoni Smp_001090   nuclear pore complex protein
Schistosoma mansoni Smp_131140   hypothetical protein
Schistosoma mansoni Smp_141870   hypothetical protein
Schistosoma mansoni Smp_110650   hypothetical protein
Schistosoma mansoni Smp_126570   hypothetical protein
Schistosoma mansoni Smp_173310   hypothetical protein
Schistosoma mansoni Smp_189260   hypothetical protein
Schistosoma mansoni Smp_190560   hypothetical protein
Schistosoma mansoni Smp_148710   hypothetical protein
Schistosoma mansoni Smp_115930   hypothetical protein
Schistosoma mansoni Smp_154310   family A2 unassigned peptidase (A02 family)
Schistosoma mansoni Smp_155710   hypothetical protein
Schistosoma mansoni Smp_082500   hypothetical protein
Schistosoma mansoni Smp_116170   hypothetical protein
Schistosoma mansoni Smp_190850   hypothetical protein
Schistosoma mansoni Smp_070720   hypothetical protein
Schistosoma mansoni Smp_155660   hypothetical protein
Schistosoma mansoni Smp_188760   hypothetical protein
Schistosoma mansoni Smp_147130   hypothetical protein
Schistosoma mansoni Smp_188770   hypothetical protein
Schistosoma mansoni Smp_167720   hypothetical protein
Schistosoma mansoni Smp_125830   hypothetical protein
Schistosoma mansoni Smp_191060   hypothetical protein
Schistosoma mansoni Smp_160720   hypothetical protein
Schistosoma mansoni Smp_190570   hypothetical protein
Schistosoma mansoni Smp_097670   hypothetical protein
Schistosoma mansoni Smp_172230   hypothetical protein
Schistosoma mansoni Smp_189170   hypothetical protein
Schistosoma mansoni Smp_110800   hypothetical protein
Schistosoma mansoni Smp_004230   hypothetical protein
Schistosoma mansoni Smp_091070   hypothetical protein
Schistosoma mansoni Smp_095200   hypothetical protein
Schistosoma mansoni Smp_190540   hypothetical protein
Schistosoma mansoni Smp_166950   hypothetical protein
Schistosoma mansoni Smp_173140   subfamily M3A non-peptidase homologue (M03 family)
Schistosoma mansoni Smp_116840   hypothetical protein
Schistosoma mansoni Smp_160990   hypothetical protein
Schistosoma mansoni Smp_140280   hypothetical protein
Schistosoma mansoni Smp_181600   hypothetical protein
Schistosoma mansoni Smp_166600   ubiquitin conjugating enzyme
Schistosoma mansoni Smp_175880   hypothetical protein
Schistosoma mansoni Smp_159820   hypothetical protein
Schistosoma mansoni Smp_174460   hypothetical protein
Schistosoma mansoni Smp_144230   hypothetical protein
Schistosoma mansoni Smp_170190   hypothetical protein
Schistosoma mansoni Smp_164870   hypothetical protein
Schistosoma mansoni Smp_072670   hypothetical protein
Schistosoma mansoni Smp_190840   hypothetical protein
Schistosoma mansoni Smp_124560   hypothetical protein
Schistosoma mansoni Smp_189710   hypothetical protein
Schistosoma mansoni Smp_193950   hypothetical protein
Schistosoma mansoni Smp_161690   hypothetical protein
Schistosoma mansoni Smp_159500   hypothetical protein
Schistosoma mansoni Smp_151170   hypothetical protein
Schistosoma mansoni Smp_138460   myelin proteolipid-related
Schistosoma mansoni Smp_082460   hypothetical protein
Schistosoma mansoni Smp_175080   hypothetical protein
Schistosoma mansoni Smp_015160   hypothetical protein
Schistosoma mansoni Smp_190310   hypothetical protein
Schistosoma mansoni Smp_170000   hypothetical protein
Schistosoma mansoni Smp_139870   hypothetical protein
Schistosoma mansoni Smp_145340   hypothetical protein
Schistosoma mansoni Smp_167560   hypothetical protein
Schistosoma mansoni Smp_164980   hypothetical protein
Schistosoma mansoni Smp_182800   hypothetical protein
Schistosoma mansoni Smp_079720   hypothetical protein
Schistosoma mansoni Smp_174330   hypothetical protein
Schistosoma mansoni Smp_190760   hypothetical protein
Schistosoma mansoni Smp_192910   hypothetical protein
Schistosoma mansoni Smp_001110   hypothetical protein
Schistosoma mansoni Smp_138650   hypothetical protein
Schistosoma mansoni Smp_160980   hypothetical protein
Schistosoma mansoni Smp_123400   hypothetical protein
Schistosoma mansoni Smp_131750   hypothetical protein
Schistosoma mansoni Smp_192090   hypothetical protein
Schistosoma mansoni Smp_192230   hypothetical protein
Schistosoma mansoni Smp_169810   hypothetical protein
Schistosoma mansoni Smp_173500   hypothetical protein
Schistosoma mansoni Smp_132360   hypothetical protein
Schistosoma mansoni Smp_149190   hypothetical protein
Schistosoma mansoni Smp_163370   hypothetical protein
Schistosoma mansoni Smp_194440   hypothetical protein
Schistosoma mansoni Smp_174600   hypothetical protein
Schistosoma mansoni Smp_004530   hypothetical protein
Schistosoma mansoni Smp_184420   hypothetical protein
Schistosoma mansoni Smp_001100   hypothetical protein
Schistosoma mansoni Smp_189250   hypothetical protein
Schistosoma mansoni Smp_071290   hypothetical protein
Schistosoma mansoni Smp_184980   hypothetical protein
Schistosoma mansoni Smp_036260   hypothetical protein
Schistosoma mansoni Smp_192010   hypothetical protein
Schistosoma mansoni Smp_177750   hypothetical protein
Schistosoma mansoni Smp_183420   hypothetical protein
Schistosoma mansoni Smp_184850   hypothetical protein
Schistosoma mansoni Smp_155830   solute carrier family 35 member C1
Schistosoma mansoni Smp_178530   hypothetical protein
Schistosoma mansoni Smp_191700   hypothetical protein
Schistosoma mansoni Smp_193130   hypothetical protein
Schistosoma mansoni Smp_136090   60S ribosomal protein L7
Schistosoma mansoni Smp_072440   hypothetical protein
Schistosoma mansoni Smp_192880   hypothetical protein
Schistosoma mansoni Smp_159610   hypothetical protein
Schistosoma mansoni Smp_192510   hypothetical protein
Schistosoma mansoni Smp_179640   hypothetical protein
Schistosoma mansoni Smp_177660   hypothetical protein
Schistosoma mansoni Smp_144150   hypothetical protein
Schistosoma mansoni Smp_183300   hypothetical protein
Schistosoma mansoni Smp_183310   hypothetical protein
Schistosoma mansoni Smp_188550   hypothetical protein
Schmidtea mediterranea mk4.013889.01  
Schmidtea mediterranea mk4.001397.04  
Schmidtea mediterranea mk4.018883.00  
Schmidtea mediterranea mk4.000323.12  
Schmidtea mediterranea mk4.001763.04  
Schmidtea mediterranea mk4.022574.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_001054000 (Echinococcus granulosus), fibrillin 2
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