pI: 8.344 |
Length (AA): 705 |
MW (Da): 78287 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
62 | 488 | 3t41 (A) | 30 | 453 | 17.00 | 0 | 0.84 | 0.621174 | 0.52 |
126 | 628 | 2id4 (A) | 122 | 589 | 36.00 | 0 | 1 | 1.06178 | -0.04 |
165 | 485 | 1r0r (E) | 7 | 275 | 29.00 | 0 | 1 | 0.630819 | -0.32 |
187 | 259 | 4lvn (A) | 370 | 455 | 42.00 | 0.0093 | 0.17 | 0.216846 | 0.88 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_130925)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_52415 | proprotein convertase 2 |
Caenorhabditis elegans | CELE_C51E3.7 | Protein EGL-3, isoform C |
Drosophila melanogaster | Dmel_CG6438 | amontillado |
Echinococcus granulosus | EgrG_000086100 | Furin 1 |
Echinococcus granulosus | EgrG_000412100 | neuroendocrine convertase 2 |
Echinococcus multilocularis | EmuJ_000412100 | neuroendocrine convertase 2 |
Echinococcus multilocularis | EmuJ_000086100 | Furin 1 |
Giardia lamblia | GL50803_2897 | Furin precursor putative serine protease |
Homo sapiens | ENSG00000125851 | proprotein convertase subtilisin/kexin type 2 |
Loa Loa (eye worm) | LOAG_12864 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08248 | proprotein convertase 2 |
Mus musculus | ENSMUSG00000027419 | proprotein convertase subtilisin/kexin type 2 |
Schistosoma japonicum | Sjp_0062970 | ko:K01360 proprotein convertase subtilisin/kexin type 2 [EC3.4.21.94], putative |
Schistosoma japonicum | Sjp_0062960 | Neuroendocrine convertase 2 precursor, putative |
Schistosoma japonicum | Sjp_0300480 | PC3-like endoprotease variant B precursor, putative |
Schistosoma mansoni | Smp_149400 | subfamily S8B unassigned peptidase (S08 family) |
Schistosoma mansoni | Smp_077980 | subfamily S8B non-peptidase homologue (S08 family) |
Schmidtea mediterranea | mk4.003468.01 | |
Trichomonas vaginalis | TVAG_325090 | neuroendocrine convertase 2 precursor, putative |
Trichomonas vaginalis | TVAG_103310 | Clan SB, family S8, subtilisin-like serine peptidase |
Trichomonas vaginalis | TVAG_282560 | Clan SB, family S8, subtilisin-like serine peptidase |
Trichomonas vaginalis | TVAG_399240 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_270490 | Clan SB, family S8, subtilisin-like serine peptidase |
Trichomonas vaginalis | TVAG_197000 | proprotein convertase subtilisin/kexin type, putative |
Trichomonas vaginalis | TVAG_028690 | Clan SB, family S8, subtilisin-like serine peptidase |
Trichomonas vaginalis | TVAG_083790 | Clan SB, family S8, subtilisin-like serine peptidase |
Trichomonas vaginalis | TVAG_321410 | Clan SB, family S8, subtilisin-like serine peptidase |
Trichomonas vaginalis | TVAG_161600 | Clan SB, family S8, subtilisin-like serine peptidase |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | proprotein convertase subtilisin/kexin type 2 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Bacillus lentus | Subtilisin | 269 aa | 27.9% | 265 aa | Compounds | References |