Detailed view for EgrG_000436200

Basic information

TDR Targets ID: 594968
Echinococcus granulosus, low density lipoprotein receptor ldl
Source Database / ID:  GeneDB

pI: 4.874 | Length (AA): 2682 | MW (Da): 296261 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00057   Low-density lipoprotein receptor domain class A
PF13927   Immunoglobulin domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 18 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
302 340 1cr8 (A) 5 44 46.00 0 0.95 0.477541 -0.04
302 337 1d2j (A) 214 249 53.00 0.00041 0.59 0.575823 0.07
435 466 2m0p (A) 1109 1140 50.00 0.073 0.75 0.659331 -0.92
702 741 2gtl (M) 62 103 48.00 0.0092 0.59 0.510314 -0.26
966 1009 1ldl (A) 2 45 43.00 0 0.74 0.507406 -0.57
1104 1145 1ldl (A) 4 45 48.00 0.000026 0.88 0.62006 -0.56
1106 1137 5oyl (D) 47 80 56.00 0.014 0.96 0.639331 -0.51
1106 1148 2i1p (A) 1188 1228 56.00 0.0013 0.87 0.462433 -0.29
1106 1144 1d2l (A) 6 44 44.00 0.00017 0.61 0.536941 -0.41
1504 1538 1d2j (A) 213 247 43.00 0 0.23 0.40705 -0.11
1505 1542 2kri (B) 126 163 42.00 0 0.56 0.474169 -0.54
1590 1682 2gtl (N) 10 106 33.00 0.27 0.1 0.192076 0.53
1769 1805 2m96 (A) 3 40 43.00 0.034 0.42 0.521196 -0.75
1771 1813 1jrf (A) 2 47 44.00 0 0.51 0.322033 -0.55
2041 2072 3a7q (B) 47 78 50.00 0.035 0.5 0.676331 -1.34
2174 2206 1ajj (A) 4 36 55.00 0.00098 0.47 0.656704 -0.67
2497 2532 2m7p (A) 13 42 57.00 0.085 0.59 0.412823 0.1
2593 2664 3ncm (A) 12 75 36.00 0 0.97 0.307846 -0.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_214569)

Species Accession Gene Product
Echinococcus granulosus EgrG_000436200   low density lipoprotein receptor ldl
Echinococcus multilocularis EmuJ_000436200   low density lipoprotein receptor (ldl)
Schistosoma japonicum Sjp_0061930   Low-density lipoprotein receptor-related protein 2 precursor, putative
Schistosoma mansoni Smp_179370   low-density lipoprotein receptor (ldl)
Schmidtea mediterranea mk4.001574.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0103 0.9438 0.9438
0.0012 0.5 0.5
0.0005 1 1
0.0163 0.3454 0.3454
0.0006 0.5 0.5
0.0006 0.5 0.5
0.0012 0.5 0.5
0.0006 0.5 0.5
0.0012 0.5 0.5
0.0006 1 1
0.0006 0.5 0.5
0.0006 0.5 0.5
0.0025 0.277 0.277
0.0006 1 1
0.0005 1 1
0.0063 0.5623 0.508
0.0006 0.5 0.5
0.0006 1 1
0.0006 0.5 0.5
0.0006 0.5 0.5
0.0012 0.5 0.5
0.0114 0.5665 0.5665
0.0089 0.4346 0.4346
0.0006 0.5 0.5
0.0005 0.5 0.5
0.0006 0.5 0.5
0.0006 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000436200 (Echinococcus granulosus), low density lipoprotein receptor ldl
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