Detailed view for Rv2381c

Basic information

TDR Targets ID: 6413
Mycobacterium tuberculosis, Polyketide synthetase MbtD (polyketide synthase)
Source Database / ID:  Tuberculist 

pI: 5.3457 | Length (AA): 1004 | MW (Da): 105592 | Paralog Number: 716

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00550   Phosphopantetheine attachment site
PF00698   Acyl transferase domain
PF08659   KR domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0031177   phosphopantetheine binding  
GO:0016740   transferase activity  
GO:0016491   oxidoreductase activity  
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0000036   acyl carrier activity  
GO:0048037   cofactor binding  
GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
419 907 4imp (A) 10 518 28.00 0 1 0.680452 0.46
669 737 6ci8 (A) 10 77 26.00 0 0.99 0.429125 -0.6
670 751 3v2h (A) 6 90 39.00 0.54 0.99 0.411873 0.3
670 837 5c37 (A) 1888 2061 29.00 0.31 1 0.503531 -0.25
910 994 5hv8 (A) 2056 2140 28.00 0.44 0.9 0.601861 -1.66
917 970 2cg5 (B) 2127 2176 40.00 0.053 0.88 0.475985 -0.33
920 1003 2jgp (A) 13 96 14.00 0.0041 0.26 0.330565 -1.11
925 1003 4zxh (A) 981 1058 26.00 0.72 0.82 0.483585 -1.03
942 990 2md9 (A) 37 85 16.00 0.027 0.72 0.356705 -1.06

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Dormant phase. murphy
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Dormant phase. hasan
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv2381c (Mycobacterium tuberculosis), Polyketide synthetase MbtD (polyketide synthase)
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