Detailed view for CaO19.4491

Basic information

TDR Targets ID: 645614
Candida albicans, similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase)
Source Database / ID:  KEGG  

pI: 4.5423 | Length (AA): 351 | MW (Da): 40713 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00348   Polyprenyl synthetase

Gene Ontology

Mouse over links to read term descriptions.
GO:0008299   isoprenoid biosynthetic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 351 3aq0 (B) 9 348 18.00 0.00000000019 1 1.0487 0.46
5 348 5cg5 (A) 11 350 46.00 0 1 1.67946 -1.59
7 351 1uby (A) 27 367 50.00 0 1 1.67931 -1.16
9 351 4kk2 (A) 11 346 49.00 0 1 1.67891 -1.6

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127590)

Species Accession Gene Product
Arabidopsis thaliana AT4G17190   farnesyl diphosphate synthase 2
Arabidopsis thaliana AT5G47770   farnesyl diphosphate synthase 1
Babesia bovis BBOV_I000120   farnesyl pyrophosphate synthetase, putative
Brugia malayi Bm1_54695   Polyprenyl synthetase family protein
Candida albicans CaO19.11967   similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase)
Candida albicans CaO19.4491   similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase)
Caenorhabditis elegans CELE_R06C1.2   Protein FDPS-1
Cryptosporidium hominis Chro.40285   farnesyl pyrophosphate synthase
Cryptosporidium parvum cgd4_2550   putative farnesyl pyrophosphate synthase
Dictyostelium discoideum DDB_G0268742   hypothetical protein
Dictyostelium discoideum DDB_G0278735   FDP synthase
Dictyostelium discoideum DDB_G0278823   hypothetical protein
Drosophila melanogaster Dmel_CG12389   Farnesyl pyrophosphate synthase
Echinococcus granulosus EgrG_001040000   farnesyl pyrophosphate synthase
Echinococcus multilocularis EmuJ_001040000   farnesyl pyrophosphate synthase
Giardia lamblia GL50803_6633   Farnesyl diphosphate synthase
Homo sapiens ENSG00000160752   farnesyl diphosphate synthase
Leishmania braziliensis LbrM.22.1240   farnesyl pyrophosphate synthase
Leishmania donovani LdBPK_221210.1   farnesyl pyrophosphate synthase
Leishmania infantum LinJ.22.1210   farnesyl pyrophosphate synthase
Leishmania major LmjF.22.1360   farnesyl pyrophosphate synthase
Leishmania mexicana LmxM.22.1360   farnesyl pyrophosphate synthase, putative
Loa Loa (eye worm) LOAG_06272   polyprenyl synthetase
Mus musculus ensembl-mmu:ENSMUSG00000059743   farnesyl diphosphate synthetase
Mycobacterium tuberculosis Rv2173   Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Mycobacterium ulcerans MUL_0373   geranylgeranyl pyrophosphate synthase
Mycobacterium ulcerans MUL_3516   geranylgeranyl pyrophosphate synthase
Neospora caninum NCLIV_048200   hypothetical protein
Oryza sativa 4337261   Os04g0657300
Oryza sativa 4337260   Os04g0657100
Oryza sativa 4324245   Os01g0703400
Oryza sativa 4339489   Os05g0543400
Plasmodium berghei PBANKA_0919800   geranylgeranyl pyrophosphate synthase, putative
Plasmodium falciparum PF3D7_1128400   geranylgeranyl pyrophosphate synthase, putative
Plasmodium knowlesi PKNH_0926500   geranylgeranyl pyrophosphate synthase, putative
Plasmodium vivax PVX_092040   geranylgeranyl pyrophosphate synthase
Plasmodium yoelii PY05919   farnesyl pyrophosphate synthase
Saccharomyces cerevisiae YJL167W   bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase
Schistosoma japonicum Sjp_0216390   ko:K00787 dimethylallyltranstransferase [EC2.5.1.1], putative
Schistosoma mansoni Smp_070710   farnesyl pyrophosphate synthase
Schmidtea mediterranea mk4.033514.01  
Schmidtea mediterranea mk4.003779.02   Farnesyl pyrophosphate synthase
Schmidtea mediterranea mk4.025052.00  
Trypanosoma brucei gambiense Tbg972.7.3690   farnesyl pyrophosphate synthase, putative
Trypanosoma brucei Tb927.7.3360   farnesyl pyrophosphate synthase
Trypanosoma congolense TcIL3000_7_2560   farnesyl pyrophosphate synthase
Trypanosoma cruzi TcCLB.511823.70   farnesyl pyrophosphate synthase
Trypanosoma cruzi TcCLB.508323.9   farnesyl pyrophosphate synthase, putative
Toxoplasma gondii TGME49_224490   polyprenyl synthetase superfamily protein
Theileria parva TP03_0857   farnesyl pyrophosphate synthetase, putative
Trichomonas vaginalis TVAG_150090   geranylgeranyl pyrophosphate synthase, putative
Trichomonas vaginalis TVAG_388030   geranylgeranyl pyrophosphate synthase, putative
Trichomonas vaginalis TVAG_353270   geranylgeranyl diphosphate synthase, putative

Essentiality

CaO19.4491 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.3360 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.3360 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.3360 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.3360 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_R06C1.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_R06C1.2 Caenorhabditis elegans larval arrest wormbase
CELE_R06C1.2 Caenorhabditis elegans sterile wormbase
YJL167W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0919800 Plasmodium berghei Essential plasmo
TGME49_224490 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens farnesyl diphosphate synthase Compounds References
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative Compounds References
Leishmania donovani farnesyl pyrophosphate synthase Compounds References
Trypanosoma cruzi farnesyl pyrophosphate synthase Compounds References
Toxoplasma gondii polyprenyl synthetase superfamily protein Compounds References
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative Compounds References
Leishmania major farnesyl pyrophosphate synthase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier CaO19.4491 (Candida albicans), similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase)
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