Detailed view for CaO19.12364

Basic information

TDR Targets ID: 645650
Candida albicans, hypothetical protein
Source Database / ID:  KEGG  

pI: 9.9293 | Length (AA): 160 | MW (Da): 18369 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
43 99 3brj (A) 116 172 28.00 0.4 0.08 0.48485 1.52
112 157 3l6a (A) 187 234 37.00 0.43 0.21 0.5602 0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127055)

Species Accession Gene Product
Arabidopsis thaliana AT3G45940   putative alpha-xylosidase 2
Arabidopsis thaliana AT5G11720   glycosyl hydrolases family 31 protein
Arabidopsis thaliana AT1G68560   bifunctional alpha-l-arabinofuranosidase/beta-d-xylosidase
Brugia malayi Bm1_40580   Glycosyl hydrolases family 31 protein
Candida albicans CaO19.8616   hypothetical protein
Candida albicans CaO19.12364   hypothetical protein
Candida albicans CaO19.999   closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase
Candida albicans CaO19.8614   closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase
Candida albicans CaO19.1000   hypothetical protein
Candida albicans CaO19.4899   cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose
Candida albicans CaO19.12365   cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose
Caenorhabditis elegans CELE_D2096.3   Protein AAGR-1
Caenorhabditis elegans CELE_R05F9.12   Protein AAGR-2
Dictyostelium discoideum DDB_G0269790   alpha-glucoside hydrolase
Echinococcus granulosus EgrG_000143500   lysosomal alpha glucosidase
Echinococcus multilocularis EmuJ_000141000   lysosomal alpha glucosidase
Echinococcus multilocularis EmuJ_000143500   lysosomal alpha glucosidase
Homo sapiens ENSG00000090402   sucrase-isomaltase (alpha-glucosidase)
Homo sapiens ENSG00000257335   maltase-glucoamylase (alpha-glucosidase)
Homo sapiens ENSG00000257743   maltase-glucoamylase (alpha-glucosidase)
Homo sapiens ENSG00000171298   glucosidase, alpha
Loa Loa (eye worm) LOAG_04065   glycosyl hydrolase family 31 protein
Mus musculus ENSMUSG00000027790   sucrase isomaltase (alpha-glucosidase)
Mus musculus ENSMUSG00000068587   maltase-glucoamylase
Mus musculus ENSMUSG00000025579   glucosidase, alpha, acid
Oryza sativa 4341824   Os06g0675700
Oryza sativa 4341833   Os06g0676700
Oryza sativa 4325976   Os01g0130400
Onchocerca volvulus OVOC5280  
Schistosoma japonicum Sjp_0046600   ko:K01187 alpha-glucosidase [EC3.2.1.20], putative
Schistosoma japonicum Sjp_0310090   Lysosomal alpha-glucosidase precursor, putative
Schistosoma mansoni Smp_020340   alpha-glucosidase
Schistosoma mansoni Smp_133210   alpha-glucosidase
Schmidtea mediterranea mk4.003105.00   Lysosomal alpha-glucosidase
Schmidtea mediterranea mk4.002605.04   Lysosomal alpha-glucosidase
Schmidtea mediterranea mk4.003105.02   Lysosomal alpha-glucosidase
Schmidtea mediterranea mk4.000367.05   Lysosomal alpha-glucosidase
Schmidtea mediterranea mk4.005227.01   Lysosomal alpha-glucosidase
Schmidtea mediterranea mk4.000367.07   Lysosomal alpha-glucosidase
Schmidtea mediterranea mk4.003105.01   Lysosomal alpha-glucosidase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Oryza sativa Os06g0675700 Compounds References
Rattus norvegicus Acidic alpha-glucosidase Compounds References
Oryza sativa Os06g0676700 Compounds References
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) Alpha-glucosidase Compounds References
Mus musculus sucrase isomaltase (alpha-glucosidase) Compounds References
Mus musculus glucosidase, alpha, acid Compounds References
Oryza sativa Os01g0130400 Compounds References
Rattus norvegicus Sucrase-isomaltase Compounds References
Bos taurus Alpha-glucosidase Compounds References
Homo sapiens sucrase-isomaltase (alpha-glucosidase) Compounds References
Homo sapiens glucosidase, alpha Compounds References
Homo sapiens maltase-glucoamylase (alpha-glucosidase) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CaO19.12364 (Candida albicans), hypothetical protein
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