Detailed view for CaO19.4836

Basic information

TDR Targets ID: 648169
Candida albicans, likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin
Source Database / ID:  KEGG  

pI: 9.7305 | Length (AA): 444 | MW (Da): 48426 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01180   Dihydroorotate dehydrogenase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016627   oxidoreductase activity, acting on the CH-CH group of donors  
GO:0016020   membrane  
GO:0005737   cytoplasm  
GO:0004152   dihydroorotate dehydrogenase activity  
GO:0003824   catalytic activity  
GO:0055114   oxidation reduction  
GO:0006207   'de novo' pyrimidine base biosynthetic process  

Metabolic Pathways

Pyrimidine metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
52 443 4cq8 (A) 158 566 32.00 0.000000003 1 1.24448 -0.46
63 444 4ori (A) 40 395 49.00 0 1 1.44576 -1.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127289)

Species Accession Gene Product
Arabidopsis thaliana AT5G23300   dihydroorotate dehydrogenase
Babesia bovis BBOV_II007190   dihydroorotate dehydrogenase
Brugia malayi Bm1_50015   Dihydroorotate dehydrogenase, mitochondrial precursor, putative
Brugia malayi Bm1_56440   Dihydroorotate dehydrogenase, mitochondrial precursor, putative
Candida albicans CaO19.12299   likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin
Candida albicans CaO19.4836   likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin
Caenorhabditis elegans CELE_W02D3.2   Protein DHOD-1
Drosophila melanogaster Dmel_CG9741   Dihydroorotate dehydrogenase
Escherichia coli b0945   dihydro-orotate oxidase, FMN-linked
Homo sapiens ENSG00000102967   dihydroorotate dehydrogenase (quinone)
Leishmania braziliensis LbrM.16.0550   dihydroorotate dehydrogenase
Leishmania donovani LdBPK_160540.1   dihydroorotate dehydrogenase
Leishmania infantum LinJ.16.0540   dihydroorotate dehydrogenase;with=GeneDB:LmjF16.0530
Leishmania major LmjF.16.0530   dihydroorotate dehydrogenase
Leishmania mexicana LmxM.16.0530   dihydroorotate dehydrogenase, putative
Mycobacterium leprae ML1293c   Probable dihydroorotate dehydrogenase PyrD
Mus musculus ENSMUSG00000031730   dihydroorotate dehydrogenase
Mycobacterium tuberculosis Rv2139   Probable dihydroorotate dehydrogenase PyrD
Mycobacterium ulcerans MUL_2370   dihydroorotate dehydrogenase 2
Neospora caninum NCLIV_012040   dihydroorotate dehydrogenase, putative
Oryza sativa 4337396   Os04g0676300
Plasmodium berghei PBANKA_0102100   dihydroorotate dehydrogenase, putative
Plasmodium falciparum PF3D7_0603300   dihydroorotate dehydrogenase
Plasmodium knowlesi PKNH_1147400   dihydroorotate dehydrogenase, putative
Plasmodium vivax PVX_113330   dihydroorotate dehydrogenase, mitochondrial precursor, putative
Plasmodium yoelii PY02580   dihydroorotate dehydrogenase, putative
Saccharomyces cerevisiae YKL216W   dihydroorotate dehydrogenase
Schistosoma japonicum Sjp_0002940   ko:K00226 dihydroorotate oxidase [EC1.3.3.1], putative
Schistosoma mansoni Smp_078730   dihydroorotate dehydrogenase
Schmidtea mediterranea mk4.000860.06   Dihydroorotate dehydrogenase
Schmidtea mediterranea mk4.028649.02  
Trypanosoma brucei gambiense Tbg972.5.5320   dihydroorotate dehydrogenase, putative
Trypanosoma brucei Tb927.5.3830   dihydroorotate dehydrogenase (fumarate)
Trypanosoma congolense TcIL3000_5_4300   dihydroorotate dehydrogenase, putative
Trypanosoma cruzi TcCLB.511643.20   dihydroorotate dehydrogenase, putative
Trypanosoma cruzi TcCLB.507091.40   dihydroorotate dehydrogenase, putative
Trypanosoma cruzi TcCLB.508375.50   dihydroorotate dehydrogenase (fumarate), putative
Toxoplasma gondii TGME49_210790   dihydroorotate dehydrogenase reveal, putative
Theileria parva TP02_0171   dihydroorotate dehydrogenase, putative
Wolbachia endosymbiont of Brugia malayi Wbm0098   dihydroorotate dehydrogenase 2

Essentiality

CaO19.4836 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2172 Mycobacterium tuberculosis non-essential nmpdr
Tb927.5.3830 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.3830 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.5.3830 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.5.3830 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b0945 Escherichia coli non-essential goodall
PBANKA_0102100 Plasmodium berghei Slow plasmo
TGME49_210790 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Dihydroorotate dehydrogenase Compounds References
Mus musculus dihydroorotate dehydrogenase Compounds References
Plasmodium berghei dihydroorotate dehydrogenase, putative Compounds References
Homo sapiens dihydroorotate dehydrogenase (quinone) Compounds References
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative Compounds References
Plasmodium falciparum dihydroorotate dehydrogenase Compounds References
Saccharomyces cerevisiae dihydroorotate dehydrogenase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier CaO19.4836 (Candida albicans), likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin
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