pI: 4.7932 |
Length (AA): 862 |
MW (Da): 96933 |
Paralog Number:
6
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
10 | 855 | 5nn4 (A) | 82 | 851 | 33.00 | 0 | 1 | 1.25674 | -0.27 |
62 | 856 | 3weo (A) | 43 | 788 | 36.00 | 0 | 1 | 1.24157 | -0.31 |
186 | 780 | 6c9x (A) | 40 | 571 | 30.00 | 0 | 1 | 0.983855 | -0.43 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127055)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G45940 | putative alpha-xylosidase 2 |
Arabidopsis thaliana | AT5G11720 | glycosyl hydrolases family 31 protein |
Arabidopsis thaliana | AT1G68560 | bifunctional alpha-l-arabinofuranosidase/beta-d-xylosidase |
Brugia malayi | Bm1_40580 | Glycosyl hydrolases family 31 protein |
Candida albicans | CaO19.8616 | hypothetical protein |
Candida albicans | CaO19.12364 | hypothetical protein |
Candida albicans | CaO19.999 | closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase |
Candida albicans | CaO19.8614 | closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase |
Candida albicans | CaO19.1000 | hypothetical protein |
Candida albicans | CaO19.4899 | cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose |
Candida albicans | CaO19.12365 | cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose |
Caenorhabditis elegans | CELE_D2096.3 | Protein AAGR-1 |
Caenorhabditis elegans | CELE_R05F9.12 | Protein AAGR-2 |
Dictyostelium discoideum | DDB_G0269790 | alpha-glucoside hydrolase |
Echinococcus granulosus | EgrG_000143500 | lysosomal alpha glucosidase |
Echinococcus multilocularis | EmuJ_000141000 | lysosomal alpha glucosidase |
Echinococcus multilocularis | EmuJ_000143500 | lysosomal alpha glucosidase |
Homo sapiens | ENSG00000090402 | sucrase-isomaltase (alpha-glucosidase) |
Homo sapiens | ENSG00000257335 | maltase-glucoamylase (alpha-glucosidase) |
Homo sapiens | ENSG00000257743 | maltase-glucoamylase (alpha-glucosidase) |
Homo sapiens | ENSG00000171298 | glucosidase, alpha |
Loa Loa (eye worm) | LOAG_04065 | glycosyl hydrolase family 31 protein |
Mus musculus | ENSMUSG00000027790 | sucrase isomaltase (alpha-glucosidase) |
Mus musculus | ENSMUSG00000068587 | maltase-glucoamylase |
Mus musculus | ENSMUSG00000025579 | glucosidase, alpha, acid |
Oryza sativa | 4341824 | Os06g0675700 |
Oryza sativa | 4341833 | Os06g0676700 |
Oryza sativa | 4325976 | Os01g0130400 |
Onchocerca volvulus | OVOC5280 |
|
Schistosoma japonicum | Sjp_0046600 | ko:K01187 alpha-glucosidase [EC3.2.1.20], putative |
Schistosoma japonicum | Sjp_0310090 | Lysosomal alpha-glucosidase precursor, putative |
Schistosoma mansoni | Smp_020340 | alpha-glucosidase |
Schistosoma mansoni | Smp_133210 | alpha-glucosidase |
Schmidtea mediterranea | mk4.003105.00 | Lysosomal alpha-glucosidase |
Schmidtea mediterranea | mk4.002605.04 | Lysosomal alpha-glucosidase |
Schmidtea mediterranea | mk4.003105.02 | Lysosomal alpha-glucosidase |
Schmidtea mediterranea | mk4.000367.05 | Lysosomal alpha-glucosidase |
Schmidtea mediterranea | mk4.005227.01 | Lysosomal alpha-glucosidase |
Schmidtea mediterranea | mk4.000367.07 | Lysosomal alpha-glucosidase |
Schmidtea mediterranea | mk4.003105.01 | Lysosomal alpha-glucosidase |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | Sucrase-isomaltase | Compounds | References |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | Alpha-glucosidase | Compounds | References |
Homo sapiens | sucrase-isomaltase (alpha-glucosidase) | Compounds | References |
Bos taurus | Alpha-glucosidase | Compounds | References |
Mus musculus | glucosidase, alpha, acid | Compounds | References |
Mus musculus | sucrase isomaltase (alpha-glucosidase) | Compounds | References |
Homo sapiens | glucosidase, alpha | Compounds | References |
Rattus norvegicus | Acidic alpha-glucosidase | Compounds | References |
Oryza sativa | Os01g0130400 | Compounds | References |
Oryza sativa | Os06g0675700 | Compounds | References |
Oryza sativa | Os06g0676700 | Compounds | References |
Homo sapiens | maltase-glucoamylase (alpha-glucosidase) | Compounds | References |