pI: 4.5189 |
Length (AA): 258 |
MW (Da): 29384 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 253 | 4i6n (A) | 0 | 221 | 24.00 | 0 | 1 | 1.14262 | -0.45 |
5 | 256 | 1xd3 (A) | 2 | 230 | 35.00 | 0 | 1 | 1.41474 | -1.11 |
7 | 256 | 1cmx (A) | 6 | 234 | 39.00 | 0 | 1 | 1.34729 | -0.74 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127717)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G17510 | ubiquitin C-terminal hydrolase 3 |
Babesia bovis | BBOV_III010630 | ubiquitin carboxyl-terminal hydrolase, family 1 protein |
Brugia malayi | Bm1_09170 | Ubiquitin carboxyl-terminal hydrolase, family 1 protein |
Candida albicans | CaO19.13651 | potential ubiquitin carboxyl-terminal hydrolase similar to S. cerevisiae YUH1 (YJR099W) |
Candida albicans | CaO19.6272 | potential ubiquitin carboxyl-terminal hydrolase similar to S. cerevisiae YUH1 (YJR099W) |
Caenorhabditis elegans | CELE_Y40G12A.1 | Protein UBH-3 |
Caenorhabditis elegans | CELE_F46E10.8 | Protein UBH-1 |
Cryptosporidium hominis | Chro.80372 | ubiquitin carboxy-terminal hydrolase L1; gracile axonal dystrophy; protein gene product 9.5 |
Cryptosporidium parvum | cgd8_3200 | ubiquitin C-terminal hydrolase of the cysteine proteinase fold |
Dictyostelium discoideum | DDB_G0282007 | peptidase C12 family protein |
Drosophila melanogaster | Dmel_CG4265 | Ubiquitin carboxy-terminal hydrolase |
Echinococcus granulosus | EgrG_001029600 | ubiquitin carboxyl terminal hydrolase isozyme |
Echinococcus multilocularis | EmuJ_001029600 | ubiquitin carboxyl terminal hydrolase isozyme |
Homo sapiens | ENSG00000118939 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) |
Homo sapiens | ENSG00000154277 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
Leishmania braziliensis | LbrM.25.0190 | ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative |
Leishmania donovani | LdBPK_250190.1 | ubiquitin carboxyl-terminal hydrolase, putative |
Leishmania infantum | LinJ.25.0190 | ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative |
Leishmania major | LmjF.25.0190 | ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative |
Leishmania mexicana | LmxM.25.0190 | ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative |
Loa Loa (eye worm) | LOAG_03494 | hypothetical protein |
Mus musculus | ENSMUSG00000029223 | ubiquitin carboxy-terminal hydrolase L1 |
Mus musculus | ENSMUSG00000022111 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) |
Neospora caninum | NCLIV_024470 | hypothetical protein |
Oryza sativa | 4337328 | Os04g0667500 |
Oryza sativa | 4330187 | Os02g0654500 |
Plasmodium berghei | PBANKA_1324100 | ubiquitin carboxyl-terminal hydrolase isozyme L3, putative |
Plasmodium falciparum | PF3D7_1460400 | ubiquitin carboxyl-terminal hydrolase isozyme L3 |
Plasmodium knowlesi | PKNH_1221300 | ubiquitin carboxyl-terminal hydrolase isozyme L3, putative |
Plasmodium vivax | PVX_117435 | ubiquitin carboxyl-terminal hydrolase isozyme L3, putative |
Plasmodium yoelii | PY01755 | hypothetical protein |
Saccharomyces cerevisiae | YJR099W | Yuh1p |
Schistosoma japonicum | Sjp_0205820 | ko:K05609 ubiquitin carboxyl-terminal hydrolase L3, putative |
Schistosoma mansoni | Smp_168800.4 | family C12 unassigned peptidase (C12 family) |
Schistosoma mansoni | Smp_168800.2 | family C12 unassigned peptidase (C12 family) |
Schistosoma mansoni | Smp_168800.1 | family C12 unassigned peptidase (C12 family) |
Schmidtea mediterranea | mk4.000885.12 | Ubiquitin carboxyl-terminal hydrolase |
Trypanosoma brucei gambiense | Tbg972.11.120 | ubiquitin carboxyl-terminal hydrolase, putative |
Trypanosoma brucei | Tb927.11.250 | ubiquitin carboxyl-terminal hydrolase, putative |
Trypanosoma congolense | TcIL3000.11.150 | ubiquitin carboxyl-terminal hydrolase, putative |
Trypanosoma cruzi | TcCLB.504109.90 | ubiquitin carboxyl-terminal hydrolase, putative |
Toxoplasma gondii | TGME49_263470 | ubiquitin carboxyl-terminal hydrolase UCHL3 |
Trichomonas vaginalis | TVAG_204450 | Clan CA, family C12, ubiquitin hydrolase-like cysteine peptidase |
Trichomonas vaginalis | TVAG_455660 | Clan CA, family C12, ubiquitin hydrolase-like cysteine peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.03.0890 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.03.0890 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.03.0890 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.03.0890 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_263470 | Toxoplasma gondii | Essentiality uncertain | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | Compounds | References |
Leishmania major | ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative | Compounds | References |
Homo sapiens | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) | Compounds | References |