Detailed view for PF3D7_0801900

Basic information

TDR Targets ID: 673
Plasmodium falciparum, conserved Plasmodium protein, unknown function
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.4484 | Length (AA): 4662 | MW (Da): 551968 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01593   Flavin containing amine oxidoreductase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016491   oxidoreductase activity  
GO:0009055   electron carrier activity  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 23 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
844 1299 1reo (A) 3 437 13.00 0 1 -0.11 0.4
875 1166 1zk7 (A) 1 305 10.00 0.0000008 0.05 0.14 -0.16
877 1209 1s3e (A) 3 337 15.00 0 1 0.16 0.24
305 379 3k29 (A) 87 161 31.00 0.69 0.11 0.920987 -5.95
880 916 4e0v (A) 35 71 59.00 0.79 0.92 0.624837 0.54
880 916 1sez (A) 15 51 51.00 0.66 0.77 0.555836 0.28
881 1152 4gut (A) 385 652 28.00 0.0015 1 0.136244 1.31
1019 2132 3s5m (A) 69 1189 15.00 0.0000004 0.24 0.183153 0.92
3083 3194 3kd7 (A) 7 108 9.00 0.00000044 0 0.108124 -1.27
3505 3758 4wat (A) 183 491 28.00 0.24 0.07 0.126383 0.04
3664 4140 1vqq (A) 139 628 25.00 0.52 0.88 0.0622166 1.27
4246 4521 4o87 (A) 31 318 29.00 0.041 0.17 0.00910206 1.16
4343 4531 4uos (A) 2 184 11.00 0.096 0.01 0.119641 -0.51
3 78 4tql (A) 115 192 12.00 0.75 0.09 0.234582 -1.12
872 908 4e0v (A) 35 71 59.00 0.85 0.92 0.623024 0.54
872 908 1sez (A) 15 51 51.00 0.7 0.77 0.554024 0.28
873 1144 4gut (A) 385 652 28.00 0.0016 1 0.134989 1.31
1357 1907 3ffz (A) 659 1146 28.00 0.11 0.63 0.0694969 1.5
2062 2165 4r58 (A) 117 220 25.00 0.18 0.97 0.270555 -0.34
3515 3763 4wat (A) 183 491 28.00 0.37 0.11 0.0810013 0.21
3692 4001 4k1p (A) 39 352 16.00 0.73 0.08 0.103331 -0.21
3865 4035 3na7 (A) 12 181 15.00 0.03 0.03 0.173185 -0.66
4191 4467 4o87 (A) 31 318 29.00 0.045 0.11 -0.00992626 1.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile sporozoite, Sporozoite, Female Gametocyte. PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile gametocyte, merozoite, early ring, late ring, Ring. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 16 hs, early trophozoite, late trophozoite, Male Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, early schizont, Oocyst. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. Otto TD
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_163914)

Species Accession Gene Product
Plasmodium berghei PBANKA_1228300   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_0801900   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_0117000   reductase, putative
Plasmodium vivax PVX_093645   hypothetical protein, conserved
Plasmodium yoelii PY02606   amine oxidase, flavin-containing, putative
Schistosoma japonicum Sjp_0122970   hypothetical protein
Schistosoma japonicum Sjp_0128780   Conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0109 1 0.5
0.011 0.3084 0.5
0.0135 0.4325 0.5
0.0042 0.2805 0.5
0.0062 1 0.5
0.0153 1 0.5
0.0131 0.5 0.5
0.0063 1 0.5
0.0177 0.4028 0.5
0.0042 0.5 0.5
0.0239 0.2732 0.5
0.0085 1 0.5
0.0023 0.5 0.5
0.0086 0.5 0.5
0.0137 0.7284 0.5
0.0025 0.4128 0.5
0.0282 0.5 0.5
0.0065 1 0.5
0.0064 1 0.5
0.0041 1 0.5
0.0262 1 0.5
0.0217 1 1
0.0419 1 0.5
0.0048 0.6551 0.6354
0.0064 1 0.5
0.0051 1 1
0.014 0.9532 1
0.0108 1 0.5
0.0272 1 0.5
0.0262 1 0.5
0.0439 0.3516 0.5
0.013 1 0.5
0.0478 0.2943 0.399
0.0255 0.6236 0.5
0.0023 0.5 0.5
0.0087 0.3247 0.5
0.0063 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_0801900 (Plasmodium falciparum), conserved Plasmodium protein, unknown function
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