Detailed view for Rv0683

Basic information

TDR Targets ID: 7078
Mycobacterium tuberculosis, 30S ribosomal protein S7 RpsG
Source Database / ID:  Tuberculist 

pI: 11.1855 | Length (AA): 156 | MW (Da): 17600 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00177   Ribosomal protein S7p/S5e

Gene Ontology

Mouse over links to read term descriptions.
GO:0015935   small ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0003723   RNA binding  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 156 2vqe (G) 2 156 54.00 0 1 1.73709 -1.11
10 148 1hus (A) 9 147 63.00 0 1 1.77663 -1.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Dormant phase. murphy
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Dormant phase. hasan
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

Ortholog group members (OG5_127867)

Species Accession Gene Product
Arabidopsis thaliana ArthCp069   30S ribosomal protein S7
Arabidopsis thaliana ArthCp088   30S ribosomal protein S7
Arabidopsis thaliana ArthMp103   ribosomal protein S7
Arabidopsis thaliana AT2G07696   ribosomal protein S7
Brugia malayi Bm1_18035   Ribosomal protein S7p/S5e containing protein
Candida albicans CaO19.11501   potential mitochondrial ribosomal protein similar to S. cerevisiae RSM7 (YJR113C) small subunit protein (E. coli S7)
Candida albicans CaO19.4018   potential mitochondrial ribosomal protein similar to S. cerevisiae RSM7 (YJR113C) small subunit protein (E. coli S7)
Caenorhabditis elegans CELE_Y57G11C.34   Protein MRPS-7
Chlamydia trachomatis CT_438   30S ribosomal protein S7
Dictyostelium discoideum DidioMp23   ribosomal protein S7
Drosophila melanogaster Dmel_CG5108   mitochondrial ribosomal protein S7
Escherichia coli b3341   30S ribosomal subunit protein S7
Echinococcus granulosus EgrG_000424500   28S ribosomal protein S7 mitochondrial
Echinococcus multilocularis EmuJ_000424500   28S ribosomal protein S7, mitochondrial
Homo sapiens ENSG00000125445   mitochondrial ribosomal protein S7
Leishmania braziliensis LbrM.11.0770   40S ribosomal protein S5
Leishmania infantum LinJ.11.0970   40S ribosomal protein S5
Loa Loa (eye worm) LOAG_02465   ribosomal protein S7p/S5e containing protein
Mycobacterium leprae ML1879c   PROBABLE 30S RIBOSOMAL PROTEIN S7 RPSG
Mus musculus 50529   mitchondrial ribosomal protein S7
Mycobacterium tuberculosis Rv0683   30S ribosomal protein S7 RpsG
Mycobacterium ulcerans MUL_0764   30S ribosomal protein S7
Oryza sativa 3131445   30S ribosomal protein S7
Oryza sativa 6450151   ribosomal protein S7
Oryza sativa 3131444   30S ribosomal protein S7
Oryza sativa 9271546   Os04g0237800
Saccharomyces cerevisiae YJR113C   mitochondrial 37S ribosomal protein RSM7
Schistosoma japonicum Sjp_0081650   ko:K02992 small subunit ribosomal protein S7, putative
Schistosoma mansoni Smp_108260   30S ribosomal protein S7
Schistosoma mansoni Smp_165830   mitochondrial ribosomal protein S7
Schmidtea mediterranea mk4.000296.03   28S ribosomal protein S7, mitochondrial
Treponema pallidum TP0244   30S ribosomal protein S7
Wolbachia endosymbiont of Brugia malayi Wbm0345   30S ribosomal protein S7

Essentiality

Rv0683 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu695 this record Mycobacterium tuberculosis essential nmpdr
b3341 Escherichia coli essential goodall
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv0683 (Mycobacterium tuberculosis), 30S ribosomal protein S7 RpsG
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