pI: 10.0249 |
Length (AA): 144 |
MW (Da): 16428 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 143 | 5hhj (A) | 92 | 234 | 12.00 | 0.000000064 | 0.01 | 1.05166 | 0.5 |
24 | 78 | 2dgj (A) | 143 | 196 | 31.00 | 0.51 | 0.01 | 0.604944 | 0.31 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126627)
Species | Accession | Gene Product |
---|---|---|
Drosophila melanogaster | Dmel_CG11231 | CG11231 gene product from transcript CG11231-RA |
Echinococcus granulosus | EgrG_000774300 | gastrula zinc finger protein xFG20 1 |
Giardia lamblia | GL50803_92977 | Reverse transcriptase/endonuclease, putative |
Leishmania donovani | LdBPK_201590.1 | hypothetical protein, unknown function |
Leishmania infantum | LinJ.20.1590 | hypothetical protein, unknown function |
Leishmania major | LmjF.20.1750 | hypothetical protein |
Leishmania major | LmjF.20.1540 | hypothetical protein, unknown function |
Leishmania mexicana | LmxM.20.1540 | hypothetical protein, unknown function |
Schistosoma japonicum | Sjp_0316270 | expressed protein |
Schistosoma japonicum | Sjp_0306130 | IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing |
Schistosoma mansoni | Smp_186470 | hypothetical protein |
Schistosoma mansoni | Smp_186490 | hypothetical protein |
Schmidtea mediterranea | mk4.002710.04 | |
Trypanosoma brucei gambiense | Tbg972.3.3580 | hypothetical protein, conserved |
Trypanosoma brucei gambiense | Tbg972.5.3100 | hypothetical protein, unlikely |
Trypanosoma brucei gambiense | Tbg972.10.20 | hypothetical protein, conserved |
Trypanosoma brucei gambiense | Tbg972.8.8010 | |
Trypanosoma brucei gambiense | Tbg972.5.3110 | hypothetical protein, unlikely |
Trypanosoma brucei gambiense | Tbg972.11.4440 | |
Trypanosoma brucei gambiense | Tbg972.8.6720 | |
Trypanosoma brucei gambiense | Tbg972.11.18170 | hypothetical protein, conserved |
Trypanosoma brucei | Tb11.v5.1020 | retrotransposon hot spot (RHS) protein, putative |
Trypanosoma brucei | Tb927.10.16200 | Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative |
Trypanosoma congolense | TcIL3000_0_24740 | Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative |
Trypanosoma congolense | TcIL3000_0_05970 | RNase H/C2H2 type zinc-finger (2 copies)/C2H2-type zinc finger containing protein, putative |
Trypanosoma congolense | TcIL3000_0_05880 | reverse transcriptase (RNA-dependent DNA polymerase), putative |
Trypanosoma congolense | TcIL3000_0_38320 | Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H, putative |
Trypanosoma congolense | TcIL3000_0_32200 | Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H, putative |
Trypanosoma congolense | TcIL3000_0_37120 | Endonuclease-reverse transcriptase, putative |
Trypanosoma congolense | TcIL3000_0_28460 | RNase H, putative |
Trypanosoma congolense | TcIL3000_0_39430 | Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative |
Trypanosoma congolense | TcIL3000_0_49660 | Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative |
Trypanosoma congolense | TcIL3000_0_14950 | RNase H, putative |
Trypanosoma congolense | TcIL3000_0_43720 | RNase H/Zinc finger, C2H2 type, putative |
Trypanosoma congolense | TcIL3000_0_17230 | reverse transcriptase (RNA-dependent DNA polymerase), putative |
Trypanosoma congolense | TcIL3000_0_43730 | Endonuclease-reverse transcriptase, putative |
Trypanosoma congolense | TcIL3000_0_58830 | Endonuclease-reverse transcriptase, putative |
Trypanosoma congolense | TcIL3000_0_32280 | Zinc finger, C2H2 type/C2H2-type zinc finger containing protein, putative |
Trypanosoma congolense | TcIL3000_0_22180 | Endonuclease-reverse transcriptase, putative |
Trypanosoma congolense | TcIL3000_0_49570 | Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative |
Trypanosoma congolense | TcIL3000_0_45590 | Endonuclease-reverse transcriptase, putative |
Trypanosoma congolense | TcIL3000_0_28690 | Endonuclease-reverse transcriptase, putative |
Trypanosoma congolense | TcIL3000_0_28760 | Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H/Zinc finger, C2H2 type, putative |
Trypanosoma congolense | TcIL3000_0_49560 | Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H/Zinc finger, C2H2 type/C2H2-type zinc finger containing protein, pu |
Trypanosoma congolense | TcIL3000_0_18610 | Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H, putative |
Trypanosoma congolense | TcIL3000_0_49670 | RNase H/Zinc finger, C2H2 type/C2H2-type zinc finger containing protein, putative |
Trypanosoma congolense | TcIL3000_0_03680 | Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H/Zinc finger, C2H2 type/C2H2-type zinc finger containing protein, pu |
Trypanosoma cruzi | TcCLB.508681.31 | hypothetical protein |
Trypanosoma cruzi | TcCLB.510481.30 | hypothetical protein, conserved |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.