pI: 6.2188 |
Length (AA): 224 |
MW (Da): 24797 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 214 | 2xf4 (A) | 1 | 202 | 27.00 | 0 | 1 | 1.37263 | -1.22 |
3 | 222 | 5lcf (A) | 57 | 260 | 18.00 | 0 | 1 | 1.10634 | -0.1 |
3 | 214 | 2zwr (A) | 1 | 194 | 34.00 | 0 | 1 | 1.38563 | -1.08 |
175 | 211 | 3dm8 (A) | 44 | 80 | 38.00 | 0.66 | 0.25 | 0.476979 | 0.87 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127147)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G53580 | persulfide dioxygenase ETHE1-like protein |
Brugia malayi | Bm1_46955 | probable glyoxalase II, 78941-80643 |
Brugia malayi | Bm1_46960 | ethe1-prov protein |
Caenorhabditis elegans | CELE_C33A12.7 | Protein ETHE-1 |
Dictyostelium discoideum | DDB_G0291482 | beta-lactamase domain-containing protein |
Drosophila melanogaster | Dmel_CG30022 | CG30022 gene product from transcript CG30022-RB |
Escherichia coli | b0927 | putative metal-binding enzyme |
Echinococcus granulosus | EgrG_001090400 | ETHE1 protein |
Entamoeba histolytica | EHI_068560 | metallo-beta-lactamase family protein |
Echinococcus multilocularis | EmuJ_001090400 | ETHE1 protein |
Giardia lamblia | GL50803_15305 | Hydroxyacylglutathione hydrolase |
Giardia lamblia | GL50803_8913 | Hydroxyacylglutathione hydrolase |
Homo sapiens | ENSG00000105755 | ethylmalonic encephalopathy 1 |
Loa Loa (eye worm) | LOAG_00527 | hypothetical protein |
Mycobacterium leprae | ML0493 | Possible glyoxalase II (Hydroxyacylglutathione hydrolase) (GLX II) |
Mus musculus | ENSMUSG00000064254 | ethylmalonic encephalopathy 1 |
Mycobacterium tuberculosis | Rv2581c | Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) |
Mycobacterium tuberculosis | Rv2260 | Conserved hypothetical protein |
Mycobacterium ulcerans | MUL_1291 | hypothetical protein |
Mycobacterium ulcerans | MUL_1731 | Zn-dependent glyoxylase |
Oryza sativa | 4326319 | Os01g0667200 |
Schistosoma japonicum | Sjp_0023140 | ko:K01774 ethe1; ethylmalonic encephalopathy 1, putative |
Schistosoma mansoni | Smp_080670 | hypothetical protein |
Schistosoma mansoni | Smp_165640 | beta lactamase domain |
Schmidtea mediterranea | mk4.012437.00 | Persulfide dioxygenase ETHE1, mitochondrial |
Schmidtea mediterranea | mk4.008670.00 | Persulfide dioxygenase ETHE1, mitochondrial |
Schmidtea mediterranea | mk4.000253.01 | Persulfide dioxygenase ETHE1, mitochondrial |
Trichomonas vaginalis | TVAG_233760 | beta lactamase domain, putative |
Trichomonas vaginalis | TVAG_452590 | beta lactamase domain, putative |
Trichomonas vaginalis | TVAG_019300 | beta lactamase domain, putative |
Trichomonas vaginalis | TVAG_132210 | beta lactamase domain, putative |
Trichomonas vaginalis | TVAG_411410 | beta lactamase domain, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2295 | Mycobacterium tuberculosis | essential | nmpdr |
b0927 | Escherichia coli | non-essential | goodall |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.