pI: 9.7518 |
Length (AA): 635 |
MW (Da): 73587 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
27 | 633 | 1k4t (A) | 202 | 743 | 46.00 | 0 | 1 | 1.26911 | 0.69 |
27 | 456 | 2b9s (A) | 27 | 456 | 99.99 | 0 | 1 | 1.84527 | -0.75 |
503 | 596 | 3uf1 (A) | 151 | 244 | 16.00 | 0.95 | 0.01 | 0.386231 | -1.05 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127702)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G55310 | DNA topoisomerase 1 beta |
Arabidopsis thaliana | AT5G55300 | DNA topoisomerase 1 |
Babesia bovis | BBOV_II007450 | DNA topoisomerase |
Brugia malayi | Bm1_41680 | DNA topoisomerase I |
Candida albicans | CaO19.96 | likely DNA topoisomerase I similar to S. cerevisiae TOP1 (YOL006C) |
Candida albicans | CaO19.7742 | likely DNA topoisomerase I similar to S. cerevisiae TOP1 (YOL006C) |
Caenorhabditis elegans | CELE_M01E5.5 | Protein TOP-1, isoform A |
Cryptosporidium hominis | Chro.70373 | DNA topoisomerase I |
Cryptosporidium parvum | cgd7_3350 | eukaryotic DNA topoisomerase I |
Dictyostelium discoideum | DDB_G0283205 | DNA topoisomerase I |
Drosophila melanogaster | Dmel_CG6146 | Topoisomerase 1 |
Echinococcus granulosus | EgrG_000700500 | DNA topoisomerase 1 |
Echinococcus multilocularis | EmuJ_000700500 | DNA topoisomerase 1 |
Homo sapiens | ENSG00000198900 | topoisomerase (DNA) I |
Homo sapiens | ENSG00000184428 | topoisomerase (DNA) I, mitochondrial |
Leishmania braziliensis | LbrM.20.3020 | DNA topoisomerase IB, large subunit |
Leishmania donovani | LdBPK_343220.1 | DNA topoisomerase IB, large subunit |
Leishmania infantum | LinJ.34.3220 | DNA topoisomerase IB, large subunit |
Leishmania major | LmjF.34.3440 | DNA topoisomerase IB, large subunit |
Leishmania mexicana | LmxM.33.3440 | DNA topoisomerase IB, large subunit |
Loa Loa (eye worm) | LOAG_09811 | DNA topoisomerase I |
Mus musculus | ENSMUSG00000070544 | topoisomerase (DNA) I |
Mus musculus | ENSMUSG00000000934 | DNA topoisomerase 1, mitochondrial |
Neospora caninum | NCLIV_049500 | hypothetical protein |
Oryza sativa | 4344685 | Os08g0154600 |
Plasmodium berghei | PBANKA_1110100 | topoisomerase I, putative |
Plasmodium falciparum | PF3D7_0510500 | topoisomerase I |
Plasmodium knowlesi | PKNH_1023100 | topoisomerase I, putative |
Plasmodium vivax | PVX_098085 | topoisomerase I, putative |
Plasmodium yoelii | PY05226 | Eukaryotic DNA topoisomerase I, DNA binding, putative |
Saccharomyces cerevisiae | YOL006C | DNA topoisomerase 1 |
Schistosoma japonicum | Sjp_0092890 | ko:K03163 DNA topoisomerase I, putative |
Schistosoma japonicum | Sjp_0317930 | IPR011010,DNA breaking-rejoining enzyme, catalytic core,domain-containing |
Schistosoma mansoni | Smp_033050.2 | DNA topoisomerase type I |
Schistosoma mansoni | Smp_033050.3 | DNA topoisomerase type I |
Schistosoma mansoni | Smp_033050.1 | DNA topoisomerase type I |
Schmidtea mediterranea | mk4.009207.00 | DNA topoisomerase 1 |
Trypanosoma brucei gambiense | Tbg972.4.1160 | DNA topoisomerase IB, large subunit, putative |
Trypanosoma brucei | Tb927.4.1330 | DNA topoisomerase IB, large subunit |
Trypanosoma cruzi | TcCLB.508693.20 | DNA topoisomerase IB, large subunit, putative |
Toxoplasma gondii | TGME49_234360 | DNA topoisomerase I, putative |
Theileria parva | TP02_0198 | DNA topoisomerase I, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.1330 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.1330 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.1330 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.4.1330 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_M01E5.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_M01E5.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_M01E5.5 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_M01E5.5 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_234360 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Chlorocebus aethiops | DNA topoisomerase 1 | Compounds | References |
Homo sapiens | topoisomerase (DNA) I | Compounds | References |
Saccharomyces cerevisiae | DNA topoisomerase 1 | Compounds | References |
Plasmodium falciparum | topoisomerase I | Compounds | References |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | Compounds | References |
Leishmania major | DNA topoisomerase IB, large subunit | Compounds | References |
Rattus norvegicus | DNA topoisomerase 1 | Compounds | References |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | Compounds | References |
Mus musculus | topoisomerase (DNA) I | Compounds | References |