Detailed view for PBANKA_0823400

Basic information

TDR Targets ID: 826306
Plasmodium berghei, phosphoglycerate kinase, putative
Source Database / ID: 

pI: 8.4276 | Length (AA): 416 | MW (Da): 45495 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00162   Phosphoglycerate kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004618   phosphoglycerate kinase activity  
GO:0006096   glycolysis  

Metabolic Pathways

Glycolysis / Gluconeogenesis (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 415 3oz7 (A) 2 415 86.00 0 1 2.10249 -1.53

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Gametocyte, 4 hs Ring, 16 hs Trophozoite, 22 hs Schizont, Erthyrocytic stages, Female gametocyte, Male gametocyte. Otto TD Yeoh LM
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Ookinete. Otto TD
Show/Hide expression data references
  • Yeoh LM Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates.
  • Otto TD A comprehensive evaluation of rodent malaria parasite genomes and gene expression.

Orthologs

Ortholog group members (OG5_126776)

Species Accession Gene Product
Arabidopsis thaliana AT3G12780   phosphoglycerate kinase 1
Arabidopsis thaliana AT1G56190   phosphoglycerate kinase
Arabidopsis thaliana AT1G79550   phosphoglycerate kinase
Babesia bovis BBOV_IV008070   phosphoglycerate kinase
Brugia malayi Bm1_01925   Phosphoglycerate kinase
Candida albicans CaO19.11135   3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W)
Candida albicans CaO19.3651   3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W)
Caenorhabditis elegans CELE_T03F1.3   Protein PGK-1
Cryptosporidium hominis Chro.70113   phosphoglycerate kinase
Cryptosporidium parvum cgd7_910   phosphoglycerate kinase 1
Chlamydia trachomatis CT_693   phosphoglycerate kinase
Dictyostelium discoideum DDB_G0287595   calmodulin-binding protein
Drosophila melanogaster Dmel_CG3127   Phosphoglycerate kinase
Drosophila melanogaster Dmel_CG9961   CG9961 gene product from transcript CG9961-RB
Escherichia coli b2926   phosphoglycerate kinase
Echinococcus granulosus EgrG_001043100   phosphoglycerate kinase 1
Entamoeba histolytica EHI_188180   phosphoglycerate kinase, putative
Echinococcus multilocularis EmuJ_001043100   phosphoglycerate kinase 1
Giardia lamblia GL50803_90872   Phosphoglycerate kinase
Homo sapiens 5232   phosphoglycerate kinase 2
Homo sapiens 5230   phosphoglycerate kinase 1
Leishmania braziliensis LbrM.20.4190   PGKC, phosphoglycerate kinase C
Leishmania donovani LdBPK_200110.1   phosphoglycerate kinase C, glycosomal
Leishmania infantum LinJ.20.0110   phosphoglycerate kinase C, glycosomal
Leishmania infantum LinJ.20.0120   phosphoglycerate kinase B, cytosolic
Leishmania major LmjF.20.0100   phosphoglycerate kinase C, glycosomal
Leishmania major LmjF.20.0110   phosphoglycerate kinase B, cytosolic
Leishmania mexicana LmxM.20.0100   phosphoglycerate kinase C, glycosomal
Leishmania mexicana LmxM.20.0110   phosphoglycerate kinase B, cytosolic
Loa Loa (eye worm) LOAG_06198   hypothetical protein
Mycobacterium leprae ML0571   Probable phosphoglycerate kinase Pgk
Mus musculus ENSMUSG00000062070   phosphoglycerate kinase 1
Mus musculus ENSMUSG00000031233   phosphoglycerate kinase 2
Mycobacterium tuberculosis Rv1437   Probable phosphoglycerate kinase Pgk
Mycobacterium ulcerans MUL_1829   phosphoglycerate kinase
Neospora caninum NCLIV_011270   hypothetical protein
Neospora caninum NCLIV_005420   Phosphoglycerate kinase (EC 2.7.2.3), related
Oryza sativa 4341792   Os06g0668200
Oryza sativa 4328435   Os02g0169300
Plasmodium berghei PBANKA_0823400   phosphoglycerate kinase, putative
Plasmodium falciparum PF3D7_0922500   phosphoglycerate kinase
Plasmodium knowlesi PKNH_0720500   phosphoglycerate kinase, putative
Plasmodium vivax PVX_099535   phosphoglycerate kinase, putative
Plasmodium yoelii PY04547   phosphoglycerate kinase
Saccharomyces cerevisiae YCR012W   phosphoglycerate kinase
Schistosoma japonicum Sjp_0031010   ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative
Schistosoma mansoni Smp_187370   phosphoglycerate kinase
Schistosoma mansoni Smp_018890   phosphoglycerate kinase
Schmidtea mediterranea mk4.005913.01  
Schmidtea mediterranea mk4.003849.03   Probable phosphoglycerate kinase
Schmidtea mediterranea mk4.005913.00   Phosphoglycerate kinase
Trypanosoma brucei gambiense Tbg972.1.150   phosphoglycerate kinase, putative
Trypanosoma brucei gambiense Tbg972.1.140   phosphoglycerate kinase, putative
Trypanosoma brucei Tb927.1.700   phosphoglycerate kinase
Trypanosoma brucei Tb927.1.710   phosphoglycerate kinase
Trypanosoma congolense TcIL3000_1_220   phosphoglycerate kinase
Trypanosoma congolense TcIL3000_0_37920   phosphoglycerate kinase
Trypanosoma congolense TcIL3000_1_230   phosphoglycerate kinase, putative
Trypanosoma cruzi TcCLB.505999.90   phosphoglycerate kinase, putative
Trypanosoma cruzi TcCLB.511419.40   phosphoglycerate kinase, putative
Toxoplasma gondii TGME49_222020   phosphoglycerate kinase PGKII
Toxoplasma gondii TGME49_318230   phosphoglycerate kinase PGKI
Treponema pallidum TP0538   phosphoglycerate kinase
Theileria parva TP01_0965   phosphoglycerate kinase, putative
Trichomonas vaginalis TVAG_268050   phosphoglycerate kinase, putative
Trichomonas vaginalis TVAG_383940   phosphoglycerate kinase, putative
Wolbachia endosymbiont of Brugia malayi Wbm0684   phosphoglycerate kinase

Essentiality

PBANKA_0823400 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu1460 Mycobacterium tuberculosis essential nmpdr
Tb927.1.710 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.1.710 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.1.710 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.710 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.1.700 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.1.700 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.1.700 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.700 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b2926 Escherichia coli essential goodall
YCR012W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0823400 this record Plasmodium berghei Essential plasmo
TGME49_318230 Toxoplasma gondii Probably essential sidik
TGME49_222020 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens phosphoglycerate kinase 2 Compounds References
Homo sapiens phosphoglycerate kinase 1 Compounds References
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Compounds References
Trypanosoma brucei phosphoglycerate kinase Compounds References
Saccharomyces cerevisiae phosphoglycerate kinase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PBANKA_0823400 (Plasmodium berghei), phosphoglycerate kinase, putative
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