Detailed view for PF3D7_0103400

Basic information

TDR Targets ID: 829949
Plasmodium falciparum, zinc-carboxypeptidase, putative

Source Database / ID: PlasmoDB / PF3D7_0103400  GeneDB / PF3D7_0103400

pI: 8.7868 | Length (AA): 1620 | MW (Da): 191963 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: ND

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Network

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models: 0

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127925)
Species Accession Gene Product
Brugia malayi Bm1_11405   Zinc carboxypeptidase family protein
Caenorhabditis elegans CELE_F56H1.5   Protein CCPP-1
Drosophila melanogaster Dmel_CG44533   Drosophila Nna1 ortholog
Echinococcus granulosus EgrG_000352300   cytosolic carboxypeptidase 1
Echinococcus granulosus EgrG_000261800   cytosolic carboxypeptidase 2
Echinococcus multilocularis EmuJ_000352300  
Homo sapiens ENSG00000166748   ATP/GTP binding protein-like 1
Homo sapiens ENSG00000165923   ATP/GTP binding protein-like 2
Homo sapiens ENSG00000146856   ATP/GTP binding protein-like 3
Homo sapiens ENSG00000135049   ATP/GTP binding protein 1
Leishmania braziliensis LbrM.33.0210   zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14
Leishmania donovani LdBPK_330210.1   metallo-peptidase, Clan MC, Family M14, putative
Leishmania infantum LinJ.33.0210   zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14
Leishmania major LmjF.33.0200   zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14
Leishmania mexicana LmxM.32.0200   zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14
Loa Loa (eye worm) LOAG_08804   hypothetical protein
Mus musculus ENSMUSG00000038836   ATP/GTP binding protein-like 3
Mus musculus 244071   ATP/GTP binding protein-like 1
Mus musculus ENSMUSG00000021557   ATP/GTP binding protein 1
Mus musculus ENSMUSG00000040812   ATP/GTP binding protein-like 2
Neospora caninum NCLIV_039720   zinc carboxypeptidase, putative
Plasmodium berghei PBANKA_0209700   zinc-carboxypeptidase, putative
Plasmodium falciparum PF3D7_0103400 this record   zinc-carboxypeptidase, putative
Plasmodium knowlesi PKNH_0210100   zinc-carboxypeptidase, putative
Plasmodium vivax PVX_081585   hypothetical protein, conserved
Plasmodium yoelii PY03811   Homo sapiens KIAA1035 protein-related
Schistosoma japonicum Sjp_0004350   ko:K01290 carboxypeptidase A [EC3.4.17.1], putative
Schistosoma japonicum Sjp_0113610   Cytosolic carboxypeptidase 1, putative
Schistosoma mansoni Smp_167640   peptidase
Trypanosoma brucei gambiense Tbg972.10.13020   zinc carboxypeptidase, putative,metallo- peptidase, Clan MC, Family M14
Trypanosoma brucei Tb927.10.10750   metallo-peptidase, Clan MC, Family M14, putative
Trypanosoma congolense TcIL3000_10_9050   metallo-peptidase, Clan MC, Family M14, putative
Trypanosoma cruzi TcCLB.503583.10   metallo-peptidase, Clan MC, Family M14, putative
Trypanosoma cruzi TcCLB.503489.10   metallo-peptidase, Clan MC, Family M14, putative
Toxoplasma gondii TGME49_265780   flagellar/basal body protein
Trichomonas vaginalis TVAG_027310   Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase
Trichomonas vaginalis TVAG_483870   Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase
Trichomonas vaginalis TVAG_021370   Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase
Trichomonas vaginalis TVAG_247150   Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase
Trichomonas vaginalis TVAG_453960   Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase
Trichomonas vaginalis TVAG_045700   Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase

Essentiality

PF3D7_0103400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.10750 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.10750 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.10750 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.10750 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0209700 Plasmodium berghei Dispensable plasmo
TGME49_265780 Toxoplasma gondii Probably essential sidik

Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Curated from literature

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_0103400 (Plasmodium falciparum), zinc-carboxypeptidase, putative
Title for this comment
Comment

© 2013 – 2018 Trypanosomatics Lab | IIBIO - UNSAM
© 2005 – 2012 The TDR Drug Targets Network (WHO/TDR)

TDR Targets Development Release v6, Revision: 1335 (10.Aug.2018)
Contact Us: <info at tdrtargets org>