Detailed view for TVAG_394690

Basic information

TDR Targets ID: 856745
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 6.8103 | Length (AA): 377 | MW (Da): 42780 | Paralog Number: 26

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00884   Sulfatase

Gene Ontology

Mouse over links to read term descriptions.
GO:0008484   sulfuric ester hydrolase activity  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131180)

Species Accession Gene Product
Escherichia coli b4359   phosphoglycerol transferases I and II
Plasmodium yoelii PY02809   hypothetical protein
Trichomonas vaginalis TVAG_325070   conserved hypothetical protein
Trichomonas vaginalis TVAG_131770   conserved hypothetical protein
Trichomonas vaginalis TVAG_292970   conserved hypothetical protein
Trichomonas vaginalis TVAG_110270   conserved hypothetical protein
Trichomonas vaginalis TVAG_410910   conserved hypothetical protein
Trichomonas vaginalis TVAG_025340   conserved hypothetical protein
Trichomonas vaginalis TVAG_019340   conserved hypothetical protein
Trichomonas vaginalis TVAG_084690   conserved hypothetical protein
Trichomonas vaginalis TVAG_110280   conserved hypothetical protein
Trichomonas vaginalis TVAG_507290   conserved hypothetical protein
Trichomonas vaginalis TVAG_364040   conserved hypothetical protein
Trichomonas vaginalis TVAG_463590   conserved hypothetical protein
Trichomonas vaginalis TVAG_165160   conserved hypothetical protein
Trichomonas vaginalis TVAG_117340   conserved hypothetical protein
Trichomonas vaginalis TVAG_128600   conserved hypothetical protein
Trichomonas vaginalis TVAG_019450   conserved hypothetical protein
Trichomonas vaginalis TVAG_394690   conserved hypothetical protein
Trichomonas vaginalis TVAG_146080   conserved hypothetical protein
Trichomonas vaginalis TVAG_197190   conserved hypothetical protein
Trichomonas vaginalis TVAG_145200   Phosphoglycerol transferase I, putative
Trichomonas vaginalis TVAG_148280   conserved hypothetical protein
Trichomonas vaginalis TVAG_478860   conserved hypothetical protein
Trichomonas vaginalis TVAG_373480   conserved hypothetical protein
Trichomonas vaginalis TVAG_197180   conserved hypothetical protein
Trichomonas vaginalis TVAG_413380   conserved hypothetical protein
Trichomonas vaginalis TVAG_317980   conserved hypothetical protein
Trichomonas vaginalis TVAG_493140   conserved hypothetical protein

Essentiality

TVAG_394690 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b4359 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_394690 (Trichomonas vaginalis), conserved hypothetical protein
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