Detailed view for TVAG_041600

Basic information

TDR Targets ID: 864620
Trichomonas vaginalis, cystathionine beta-lyase, putative
Source Database / ID: 

pI: 6.223 | Length (AA): 396 | MW (Da): 43042 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01053   Cys/Met metabolism PLP-dependent enzyme

Gene Ontology

Mouse over links to read term descriptions.
GO:0018826   methionine gamma-lyase activity  
GO:0030170   pyridoxal phosphate binding  
GO:0003824   catalytic activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

PDB tag
  • 1E5E:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 1E5F:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 1PFF:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126775)

Species Accession Gene Product
Arabidopsis thaliana AT3G57050   cystathionine beta-lyase
Arabidopsis thaliana AT3G01120   cystathionine gamma-synthase
Brugia malayi Bm1_05320   cystathionine gamma-lyase
Candida albicans CaO19.6402   cystathionine gamma-lyase
Candida albicans CaO19.13760   cystathionine gamma-lyase
Candida albicans CaO19.2092   cystathionine beta-lyase
Candida albicans CaO19.9639   cystathionine beta-lyase
Caenorhabditis elegans CELE_C12C8.2   Protein CBL-1, isoform A
Caenorhabditis elegans CELE_F22B8.6   Protein CTH-1, isoform B
Caenorhabditis elegans CELE_ZK1127.10   Protein CTH-2
Dictyostelium discoideum DDB_G0269122   cystathionine gamma-lyase
Drosophila melanogaster Dmel_CG5345   CG5345 gene product from transcript CG5345-RB
Escherichia coli b3939   cystathionine gamma-synthase, PLP-dependent
Entamoeba histolytica EHI_144610   methionine gamma-lyase
Entamoeba histolytica EHI_057550   methionine gamma-lyase, putative
Homo sapiens ENSG00000116761   cystathionine gamma-lyase
Leishmania braziliensis LbrM.14.0470   cystathionine beta-lyase-like protein
Leishmania braziliensis LbrM.34.3140   cystathione gamma lyase, putative
Leishmania donovani LdBPK_353280.1   cystathione gamma lyase, putative
Leishmania donovani LdBPK_140470.1   cystathionine beta-lyase-like protein
Leishmania infantum LinJ.35.3280   cystathione gamma lyase, putative
Leishmania infantum LinJ.14.0470   cystathionine beta-lyase-like protein
Leishmania major LmjF.14.0460   cystathionine beta-lyase-like protein
Leishmania major LmjF.35.3230   cystathione gamma lyase, putative
Leishmania mexicana LmxM.34.3230   cystathione gamma lyase, putative
Leishmania mexicana LmxM.14.0460   cystathionine beta-lyase-like protein
Loa Loa (eye worm) LOAG_10544   cystathionine gamma-lyase
Mycobacterium leprae ML2394c   PROBABLE CYSTATHIONINE GAMMA-SYNTHASE METB (CGS) (O-SUCCINYLHOMOSERINE [THIOL]-LYASE)
Mus musculus ENSMUSG00000028179   cystathionase (cystathionine gamma-lyase)
Mycobacterium tuberculosis Rv1079   Cystathionine gamma-synthase MetB (CGS) (O-succinylhomoserine [thiol]-lyase)
Mycobacterium tuberculosis Rv0391   Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase)
Mycobacterium ulcerans MUL_0201   cystathionine gamma-synthase
Neospora caninum NCLIV_056280   Cys/Met metabolism PLP-dependent enzyme, related
Oryza sativa 4340283   Os06g0175800
Oryza sativa 4348560   Os10g0399200
Oryza sativa 4348561   Os10g0399700
Oryza sativa 4332956   Os03g0376100
Saccharomyces cerevisiae YAL012W   cystathionine gamma-lyase CYS3
Saccharomyces cerevisiae YGL184C   cystathionine beta-lyase STR3
Schistosoma japonicum Sjp_0302890   ko:K01758 cystathionine gamma-lyase [EC4.4.1.1], putative
Schistosoma mansoni Smp_083650   cystathionine beta-lyase
Schmidtea mediterranea mk4.085557.00  
Schmidtea mediterranea mk4.003643.00   Cystathionine gamma-lyase
Schmidtea mediterranea mk4.018765.00  
Schmidtea mediterranea mk4.003986.01   Cystathionine gamma-lyase
Trypanosoma brucei gambiense Tbg972.9.7510   cystathione gamma lyase, putative
Trypanosoma brucei Tb927.9.12320   cystathione gamma lyase, putative
Trypanosoma brucei Tb11.v5.0869   cystathione gamma lyase, putative
Trypanosoma congolense TcIL3000_9_5100   cystathione gamma lyase, putative
Trypanosoma congolense TcIL3000_0_07510   cystathione gamma lyase, putative
Trypanosoma cruzi TcCLB.510661.250   cystathione gamma lyase, putative
Trypanosoma cruzi TcCLB.510741.10   cystathione gamma lyase, putative
Toxoplasma gondii TGME49_312930   cystathione gamma lyase, putative
Trichomonas vaginalis TVAG_147790   cysteine/methionine metabolism pyridoxal-5-phosphate enzymes, putative
Trichomonas vaginalis TVAG_041600   cystathionine beta-lyase, putative
Wolbachia endosymbiont of Brugia malayi Wbm0493   cystathionine beta-lyase

Essentiality

TVAG_041600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1096 Mycobacterium tuberculosis non-essential nmpdr
mtu394 Mycobacterium tuberculosis non-essential nmpdr
b3939 Escherichia coli non-essential goodall
CELE_ZK1127.10 Caenorhabditis elegans larval lethal wormbase
YAL012W Saccharomyces cerevisiae inviable yeastgenome
TGME49_312930 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_041600 (Trichomonas vaginalis), cystathionine beta-lyase, putative
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