pI: 5.2539 |
Length (AA): 876 |
MW (Da): 98241 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127465)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G22010 | replication factor C1 |
Babesia bovis | BBOV_III002070 | conserved hypothetical protein |
Brugia malayi | Bm1_07165 | ATPase, AAA family protein |
Candida albicans | CaO19.14180 | DNA replication protein RFC large subunit |
Candida albicans | CaO19.6891 | DNA replication protein RFC large subunit |
Caenorhabditis elegans | CELE_C54G10.2 | Protein RFC-1, isoform A |
Cryptosporidium hominis | Chro.80076 | replication factor C subunit 1 |
Cryptosporidium parvum | cgd8_610 | DNA replication repC1, AAA+ ATpase with a BRCT domain at the N-terminus |
Dictyostelium discoideum | DDB_G0285961 | replication factor C subunit |
Drosophila melanogaster | Dmel_CG1119 | Germ line transcription factor 1 |
Echinococcus granulosus | EgrG_000558700 | replication factor c subunit 1 |
Entamoeba histolytica | EHI_158610 | Activator 1 140 kDa subunit, putative |
Echinococcus multilocularis | EmuJ_000558700 | replication factor c subunit 1 |
Giardia lamblia | GL50803_15392 | Replication factor C, subunit 1 |
Homo sapiens | ENSG00000035928 | replication factor C (activator 1) 1, 145kDa |
Leishmania braziliensis | LbrM.24.1000 | replication factor C, subunit 1, putative |
Leishmania donovani | LdBPK_241010.1 | replication factor C, subunit 1, putative |
Leishmania infantum | LinJ.24.1010 | replication factor C, subunit 1, putative |
Leishmania major | LmjF.24.0990 | replication factor C, subunit 1, putative |
Leishmania mexicana | LmxM.24.0990 | replication factor C, subunit 1, putative |
Loa Loa (eye worm) | LOAG_04342 | ATPase |
Mus musculus | ENSMUSG00000029191 | replication factor C (activator 1) 1 |
Neospora caninum | NCLIV_049750 | replication factor c subunit, putative |
Oryza sativa | 4350754 | Os11g0572100 |
Plasmodium berghei | PBANKA_0316000 | replication factor C subunit 1, putative |
Plasmodium falciparum | PF3D7_0219600 | replication factor C subunit 1, putative |
Plasmodium knowlesi | PKNH_0401300 | replication factor C subunit 1, putative |
Plasmodium vivax | PVX_002575 | replication factor C subunit 1, putative |
Plasmodium yoelii | PY04496 | replication factor C, 140 kDa subunit |
Saccharomyces cerevisiae | YOR217W | replication factor C subunit 1 |
Schistosoma japonicum | Sjp_0028610 | ko:K10754 replication factor C subunit 1, putative |
Schistosoma japonicum | Sjp_0307270 | IPR013725,DNA replication factor C-terminal,domain-containing |
Schistosoma mansoni | Smp_004020 | chromosome transmission fidelity factor |
Schmidtea mediterranea | mk4.010009.04 | |
Schmidtea mediterranea | mk4.007203.00 | |
Schmidtea mediterranea | mk4.010009.03 | Replication factor C subunit 1 |
Trypanosoma brucei gambiense | Tbg972.11.6370 | replication factor C, subunit 1, putative,replication factor C large subunit, putative |
Trypanosoma brucei | Tb927.11.5650 | replication factor C, subunit 1, putative |
Trypanosoma congolense | TcIL3000.11.6000 | replication factor C, subunit 1, putative |
Trypanosoma cruzi | TcCLB.508647.40 | replication factor C, subunit 1, putative |
Toxoplasma gondii | TGME49_235170 | ATPase, AAA family protein |
Theileria parva | TP03_0565 | replication factor C large subunit, putative |
Trichomonas vaginalis | TVAG_184190 | chromosome transmission fidelity factor, putative |
Trichomonas vaginalis | TVAG_213910 | chromosome transmission fidelity factor, putative |
Trichomonas vaginalis | TVAG_021100 | replication factor C large subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.3360 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.3360 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.3360 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.3360 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C54G10.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C54G10.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C54G10.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C54G10.2 | Caenorhabditis elegans | sterile | wormbase |
YOR217W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0316000 | Plasmodium berghei | Dispensable | plasmo |
TGME49_235170 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.