Detailed view for TVAG_305110

Basic information

TDR Targets ID: 870524
Trichomonas vaginalis, Clan CD, family C13, legumain-like cysteine peptidase
Source Database / ID: 

pI: 5.4485 | Length (AA): 415 | MW (Da): 47265 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01650   Peptidase C13 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0008233   peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130263)

Species Accession Gene Product
Arabidopsis thaliana AT1G62710   vacuolar-processing enzyme beta
Arabidopsis thaliana AT3G20210   delta vacuolar processing enzyme
Arabidopsis thaliana AT2G25940   alpha-vacuolar processing enzyme
Arabidopsis thaliana AT4G32940   vacuolar-processing enzyme gamma
Brugia malayi Bm1_50230   Peptidase C13 family protein
Caenorhabditis elegans CELE_T28H10.3   Protein T28H10.3
Homo sapiens ENSG00000100600   legumain
Loa Loa (eye worm) LOAG_02771   peptidase C13 family protein
Mus musculus ENSMUSG00000021190   legumain
Oryza sativa 4330133   Os02g0644000
Oryza sativa 4339804   Os05g0593900
Oryza sativa 4324683   Os01g0559600
Oryza sativa 4336523   Os04g0537900
Onchocerca volvulus OVOC7039   Legumain homolog
Schistosoma japonicum Sjp_0001230   ko:K01369 legumain [EC3.4.22.34], putative
Schistosoma mansoni Smp_179170   family C13 non-peptidase homologue (C13 family)
Schistosoma mansoni Smp_075800.2   hemoglobinase (C13 family)
Schistosoma mansoni Smp_075800.1   hemoglobinase (C13 family)
Schistosoma mansoni Smp_075790   hypothetical protein
Trichomonas vaginalis TVAG_385340   Clan CD, family C13, legumain-like cysteine peptidase
Trichomonas vaginalis TVAG_426660   Clan CD, family C13, legumain-like cysteine peptidase
Trichomonas vaginalis TVAG_185540   Clan CD, family C13, legumain-like cysteine peptidase
Trichomonas vaginalis TVAG_305110   Clan CD, family C13, legumain-like cysteine peptidase
Trichomonas vaginalis TVAG_068410   Clan CD, family C13, legumain-like cysteine peptidase
Trichomonas vaginalis TVAG_050390   Clan CD, family C13, legumain-like cysteine peptidase
Trichomonas vaginalis TVAG_328450   Clan CD, family C13, legumain-like cysteine peptidase

Essentiality

TVAG_305110 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T28H10.3 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens legumain Compounds References
Mus musculus legumain Compounds References
Ixodes ricinus Legumain-like protease Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.2867 0.3749 1
0.2745 1 1
0.0814 0.6038 1
0.3085 0.6797 1
0.0448 1 0.5
0.3078 1 0.5
0.0629 1 1
0.276 0.5347 1
0.0526 1 1
0.0183 1 0.5
0.0183 1 0.5
0.2 1 1
0.0183 1 0.5
0.2867 0.3749 1
0.0787 1 1
0.3564 1 1
0.4085 1 1
0.3325 0.5296 0.7519
0.1486 0.5655 1
0.3085 0.6797 1
0.3085 0.6797 1
0.3309 1 1
0.3608 1 1
0.0524 0.9707 0.5
0.3025 1 1
0.0585 0.3414 1
0.0183 1 0.5
0.3085 0.6797 1
0.2606 1 1
0.0183 1 0.5
0.2574 1 1
0.0183 1 0.5
0.1068 1 1
0.3325 0.5296 0.7519
0.0183 1 0.5
0.3391 1 1
0.3343 1 1
0.1602 1 1
0.315 1 1
0.1773 0.3572 0.5
0.1081 0.6805 1
0.3325 0.5296 0.7519
0.3676 1 1
0.4085 1 1
0.3085 0.6797 1
0.0295 0.6123 1
0.3325 0.5296 0.7519
0.3085 0.6797 1
0.0996 1 1
0.0183 1 0.5
0.0304 1 1
0.239675 1 1
0.3535 1 1
0.3226 1 1
0.3608 1 1
0.0183 1 0.5
0.1773 1 1
0.3688 0.392 1
0.315 1 1
0.305 0.8982 1
0.1827 1 1
0.315 1 1
0.0627 1 1
0.3085 0.6797 1
0.0921 1 1
0.0149 0.5 0.5
0.0303 1 1
0.3608 1 1
0.3325 0.5296 0.7519
0.0981 1 1
0.3024 1 0.5
0.3325 0.5296 0.7519
0.3085 0.6797 1
0.1256 1 1
0.0861 1 0.5
0.0183 1 0.5
0.1166 0.996 1
0.315 1 1
0.3325 0.5296 0.7519
0.2191 1 1
0.0183 1 0.5
0.0183 1 0.5
0.1256 1 1
0.1069 1 1
0.3325 0.5296 0.7519
0.119 1 1
0.1478 1 1
0.0183 0.3639 1
0.1256 1 1
0.3325 0.5296 0.7519
0.3143 1 0.5
0.2191 1 1
0.0183 1 0.5
0.3608 1 1
0.3085 0.6797 1
0.3325 0.5296 0.7519
0.0905 0.2652 0.6375
0.1475 1 1
0.3085 0.6797 1
0.0301 1 0.5
0.0183 1 0.5
0.0183 1 0.5
0.3085 0.6797 1
0.065 1 1
0.3583 1 1
0.1327 1 1
0.1475 1 1
0.3564 1 1
0.1013 1 1
0.1538 0.9633 1
0.1773 0.3572 0.5
0.301364 1 1
0.3209 0.7271 1
0.1144 1 1
0.3325 0.5296 0.7519
0.0183 0.4693 1
0.0472 1 1
0.0183 1 0.5
0.0183 1 0.5
0.0834 1 1
0.345347 1 1
0.3226 1 1
0.0183 1 1
0.0151 0.3734 0.5989
0.0455 1 1
0.2897 1 1
0.2897 1 1
0.3325 0.5296 0.7519
0.3078 1 0.5
0.3481 1 1
0.0294 0.3957 1
0.3379 1 1
0.3608 1 1
0.3325 0.5296 0.7519
0.3085 0.6797 1
0.0684 1 1
0.3255 1 1
0.3325 0.5296 0.7519
0.3608 1 1
0.339 1 1
0.3024 1 0.5
0.1008 1 1
0.0921 1 1
0.0832 1 1
0.1068 1 1
0.0183 1 0.5
0.3123 1 1
0.0351 0.677 1
0.0183 1 0.5
0.1166 0.996 1
0.2634 1 1
0.301364 1 1
0.0921 1 1
0.301364 1 1
0.3518 1 1
0.1827 1 1
0.0183 0.5884 1
0.0589 1 1
0.356 1 1
0.1773 1 1
0.2867 0.3749 1
0.3325 0.5296 0.7519
0.0183 1 0.5
0.2518 0.524 1
0.0183 1 0.5
0.1538 0.9633 1
0.1538 0.9633 1
0.3458 1 1
0.1538 0.9633 1
0.0314 0.3488 1
0.3647 1 1
0.1166 0.996 1
0.3094 1 1
0.1538 0.9633 1
0.3325 0.5296 0.7519
0.1144 1 1
0.1853 1 1
0.356 1 1
0.0183 1 0.5
0.1538 0.9633 1
0.0183 1 0.5
0.3343 1 1
0.0183 1 1
0.3518 1 1
0.1114 1 1
0.3601 1 1
0.0183 1 0.5
0.0505 0.538 1
0.3325 0.5296 0.7519
0.3325 0.5296 0.7519
0.0959 1 1
0.035 1 1
0.3325 0.5296 0.7519
0.3518 1 1
0.0595 0.8149 1
0.2867 0.3749 1
0.0183 0.5348 1
0.3325 0.5296 0.7519
0.0183 0.4 1
0.0183 1 0.5
0.0688 0.8226 1
0.0812 1 1
0.3556 1 1
0.0848 1 0.5
0.0183 1 0.5
0.0183 1 0.5
0.0512 0.6053 1
0.0443 1 0.5
0.2867 0.3749 1
0.0183 1 0.5
0.0183 1 0.5
0.3608 1 1
0.0183 0.4593 1
0.339 1 1
0.0183 1 0.5
0.3191 1 1
0.0349 1 0.5
0.4085 1 1
0.3085 0.6797 1
0.0811 1 1
0.0795 1 1
0.1659 1 1
0.2932 1 1
0.0183 1 0.5
0.4031 1 1
0.0183 1 0.5
0.0627 1 1
0.3526 1 1
0.3325 0.5296 0.7519
0.0183 1 0.5
0.3518 1 1
0.2961 1 1
0.3085 0.6797 1
0.3535 1 1
0.3518 1 1
0.0183 1 0.5
0.0455 1 1
0.305 0.8982 1
0.3596 1 0.5
0.0183 1 0.5
0.3564 1 1
0.0501 0.6519 1
0.3325 0.5296 0.7519
0.1538 0.9633 1
0.3325 0.5296 0.7519
0.3325 0.5296 0.7519
0.3325 0.5296 0.7519
0.3085 0.6797 1
0.0183 1 0.5
0.1068 1 1
0.0482 0.4631 1
0.0183 1 0.5
0.0792 0.4512 0.9282
0.2896 1 1
0.3608 1 1
0.3325 0.5296 0.7519
0.3085 0.6797 1
0.3688 0.392 1
0.3688 0.392 1
0.0183 1 0.5
0.1114 1 1
0.0667 1 0.5
0.1114 1 1
0.352 1 1
0.3325 0.5296 0.7519
0.0183 1 0.5
0.3571 1 1
0.301364 1 1
0.1827 1 1
0.0479 1 1
0.0657 1 1
0.3535 1 1
0.276 0.5347 1
0.0183 1 0.5
0.3325 0.5296 0.7519
0.0514 0.4617 1
0.1773 0.3572 0.5
0.0443 0.3157 0.2809

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_305110 (Trichomonas vaginalis), Clan CD, family C13, legumain-like cysteine peptidase
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