Detailed view for TVAG_308120

Basic information

TDR Targets ID: 875776
Trichomonas vaginalis, short-chain dehydrogenase, putative
Source Database / ID: 

pI: 4.5073 | Length (AA): 271 | MW (Da): 30144 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00106   short chain dehydrogenase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131966)

Species Accession Gene Product
Arabidopsis thaliana AT2G29330   tropinone reductase
Arabidopsis thaliana AT1G07450   NAD(P)-binding Rossmann-fold superfamily protein
Arabidopsis thaliana AT2G29310   tropinone reductase-like protein
Arabidopsis thaliana AT2G29300   tropinone reductase-like protein
Arabidopsis thaliana AT1G07440   NAD(P)-binding Rossmann-fold superfamily protein
Arabidopsis thaliana AT2G30670   NAD(P)-binding Rossmann-fold superfamily protein
Arabidopsis thaliana AT2G29340   tropinone reductase-like protein
Arabidopsis thaliana AT2G29320   tropinone reductase-like protein
Candida albicans CaO19.10415   similar to Sou1p but not required for sorbose utilization
Candida albicans CaO19.2897   similar to SOU1 but not required for sorbose utilization
Candida albicans CaO19.2896   sorbose utilization/short-chain alcohol dehydrogenase
Candida albicans CaO19.10414   sorbose utilization/short-chain alcohol dehydrogenase
Mycobacterium tuberculosis Rv1928c   Probable short-chain type dehydrogenase/reductase
Trichomonas vaginalis TVAG_308120   short-chain dehydrogenase, putative

Essentiality

TVAG_308120 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1959 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Cochliobolus lunatus 17-beta-hydroxysteroid-dehydrogenase 270 aa 20.1% 264 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0009 0.7374 0.5
0.0119 0.2746 1
0.0196 0.8679 1
0.0046 0.3082 0
0.0021 0.3321 0.5
0.0171 0.4063 0.5
0.0004 0.5 0.5
0.0073 0.3811 1
0.0009 0.5 0.5
0.016 0.577 1
0.0108 0.5 0.5
0.0162 1 1
0.0089 0.5 0.5
0.0131 0.5 0.5
0.0402 1 1
0.0013 1 0.5
0.0016 0.5 0.5
0.0056 1 0.5
0.0056 0.875 1
0.0082 1 0.5
0.0057 0.284 0.674
0.0073 0.3811 1
0.0009 0.5 0.5
0.0012 0.5 0.5
0.007 0.2916 1
0.007 1 0.5
0.0165 1 0.5
0.0218 0.5 0.5
0.0012 0.5 0.5
0.0118 1 1
0.007 0.2916 1
0.0097 0.4304 0.5
0.0027 0.5 0.5
0.0073 0.3141 1
0.0132 0.3658 1
0.0088 0.6544 0.5
0.0102 0.7451 0.5
0.0009 0.5 0.5
0.0009 0.5 0.5
0.0114 1 0.5
0.0035 1 0.5
0.0097 1 1
0.0021 0.5 0.5
0.0073 0.2873 1
0.0106 1 1
0.0004 0.5 0.5
0.0027 0.5 0.5
0.0004 0.5 0.5
0.0408 0.5144 1
0.0053 1 1
0.007 1 0.5
0.0093 0.5 0.5
0.0114 1 0.5
0.0408 0.5144 1
0.0171 0.4063 0.5
0.0073 0.4546 1
0.0045 1 0.5
0.0039 1 0.5
0.0032 1 1
0.0068 1 0.5
0.0004 0.5 0.5
0.0009 0.5 0.5
0.0058 1 1
0.0087 0.5 0.5
0.0064 0.3508 0.5
0.0009 0.5 0.5
0.0009 0.5 0.5
0.0009 0.5 0.5
0.0408 0.5144 1
0.0021 0.3321 0.5
0.0026 0.5 0.5
0.0076 1 0.5
0.004 0.5 0.5
0.0013 0.5 0.5
0.0053 1 1
0.0084 0.4283 0.4283
0.0089 0.5 0.5
0.0085 1 1
0.007 0.2916 1
0.0058 0.3931 0.5
0.016 0.577 1
0.0222 0.5 0.5
0.0071 0.3141 0.5
0.0157 0.5 0.5
0.0067 0.3468 1
0.011 0.3568 1
0.0066 0.3586 0.5
0.0068 0.2585 1
0.0005 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0106 0.2872 0.2872
0.0004 0.5 0.5
0.0019 0.4322 1
0.0068 1 1
0.008 0.5 0.5
0.0196 0.8679 1
0.007 1 0.5
0.0113 1 1
0.0088 1 0.5
0.0005 0.5 0.5
0.0106 0.5 0.5
0.0009 1 0.5
0.0106 1 0.5
0.0123 0.5 0.5
0.0196 0.8679 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_308120 (Trichomonas vaginalis), short-chain dehydrogenase, putative
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