Detailed view for TVAG_028720

Basic information

TDR Targets ID: 901601
Trichomonas vaginalis, Clan CA, family C1, papain-like cysteine peptidase
Source Database / ID: 

pI: 5.1201 | Length (AA): 241 | MW (Da): 27610 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00112   Papain family cysteine protease

Gene Ontology

Mouse over links to read term descriptions.
GO:0008234   cysteine-type peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131485)

Species Accession Gene Product
Brugia malayi Bm1_30360   cathepsin Z-like cysteine proteinase
Brugia malayi Bm1_56735   cathepsin Z-like cysteine proteinase
Caenorhabditis elegans CELE_F32B5.8   Protein CPZ-1
Dictyostelium discoideum DDB_G0283401   cathepsin Z precursor
Dictyostelium discoideum DDB_G0280187   cathepsin Z-like protein
Giardia lamblia GL50803_16468   Cathepsin B precursor
Homo sapiens ENSG00000101160   cathepsin Z
Loa Loa (eye worm) LOAG_07418   cysteine proteinase cathepsin Z
Mus musculus ENSMUSG00000016256   cathepsin Z
Trichomonas vaginalis TVAG_488380   Clan CA, family C1, cathepsin B-like cysteine peptidase
Trichomonas vaginalis TVAG_216350   Clan CA, family C1, cathepsin B-like cysteine peptidase
Trichomonas vaginalis TVAG_454200   Clan CA, family C1, cathepsin B-like cysteine peptidase
Trichomonas vaginalis TVAG_028720   Clan CA, family C1, papain-like cysteine peptidase

Essentiality

TVAG_028720 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F32B5.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_F32B5.8 Caenorhabditis elegans larval arrest wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens cathepsin Z Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0374 0.3298 0.6244
0.0261 0.2772 1
0.0255 0.31 1
0.0279 0.7896 1
0.0252 0.3326 0.4775
0.0246 0.4963 1
0.0241 0.7509 1
0.0285 0.7415 1
0.0286 1 1
0.0265 0.6302 1
0.0526 0.2812 1
0.0677 0.2581 0.5061
0.0246 0.5055 1
0.023 0.6824 1
0.0532 0.753 1
0.0677 0.2581 0.5061
0.0281 0.2799 1
0.0286 0.8075 1
0.026 0.6695 1
0.0281 0.2799 1
0.0242 0.4895 1
0.0256 0.2781 1
0.0612 0.261 0.527
0.0225 1 1
0.0493 0.5442 1
0.0531 0.5379 1
0.03 0.6729 1
0.0242 0.4895 1
0.0374 0.3298 0.6244
0.029 0.3476 0.5426
0.025 0.3112 1
0.0256 0.2781 1
0.0359 0.3281 0.645

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_028720 (Trichomonas vaginalis), Clan CA, family C1, papain-like cysteine peptidase
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