Detailed view for TVAG_372950

Basic information

TDR Targets ID: 904583
Trichomonas vaginalis, 2-deoxyglucose-6-phosphate phosphatase, putative
Source Database / ID: 

pI: 5.1408 | Length (AA): 244 | MW (Da): 27037 | Paralog Number: 15

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13419   Haloacid dehalogenase-like hydrolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127060)

Species Accession Gene Product
Arabidopsis thaliana AT4G25840   glycerol-3-phosphatase 1
Arabidopsis thaliana AT5G57440   haloacid dehalogenase-like hydrolase family protein
Brugia malayi Bm1_20565   haloacid dehalogenase-like hydrolase family protein
Brugia malayi Bm1_29890   haloacid dehalogenase-like hydrolase family protein
Brugia malayi Bm1_29935   HAD-superfamily hydrolase, subfamily IA, variant 3 containing protein
Brugia malayi Bm1_29940   haloacid dehalogenase-like hydrolase family protein
Drosophila melanogaster Dmel_CG31924   CG31924 gene product from transcript CG31924-RB
Drosophila melanogaster Dmel_CG5565   CG5565 gene product from transcript CG5565-RA
Drosophila melanogaster Dmel_CG15441   GS1-like
Escherichia coli b1317   beta-phosphoglucomutase
Escherichia coli b1727   2-deoxyglucose-6-P phosphatase
Escherichia coli b2690   fructose-1-P and 6-phosphogluconate phosphatase
Echinococcus granulosus EgrG_000795350   HAD superfamily hydrolase
Echinococcus granulosus EgrG_001188500   haloacid dehalogenase hydrolase
Entamoeba histolytica EHI_074120   HAD hydrolase, family IA, variant 3
Entamoeba histolytica EHI_178660   HAD hydrolase, family IA, variant 3
Entamoeba histolytica EHI_088460   HAD hydrolase, family IA, variant 3
Echinococcus multilocularis EmuJ_001188500   haloacid dehalogenase hydrolase
Echinococcus multilocularis EmuJ_000795350   HAD superfamily hydrolase
Giardia lamblia GL50803_12220   Hydrolase, putative
Giardia lamblia GL50803_14038   Hydrolase, haloacid dehalogenase-like family
Homo sapiens ENSG00000130021   haloacid dehalogenase-like hydrolase domain containing 1
Loa Loa (eye worm) LOAG_13018   HAD-superfamily hydrolase
Loa Loa (eye worm) LOAG_11165   haloacid dehalogenase-like hydrolase
Loa Loa (eye worm) LOAG_06087   HAD-superfamily hydrolase
Loa Loa (eye worm) LOAG_06086   haloacid dehalogenase-like hydrolase
Loa Loa (eye worm) LOAG_10378   HAD-superfamily hydrolase
Mus musculus ENSMUSG00000048875   haloacid dehalogenase-like hydrolase domain containing 1A
Oryza sativa 4345048   Os08g0243600
Saccharomyces cerevisiae YKL033W-A   hypothetical protein
Schistosoma japonicum Sjp_0003310   ko:K01915 glutamine synthetase [EC6.3.1.2], putative
Schistosoma mansoni Smp_042390   2-deoxyglucose-6-phosphate phosphatase
Schmidtea mediterranea mk4.063706.00  
Schmidtea mediterranea mk4.000461.09   Pseudouridine-5'-monophosphatase
Schmidtea mediterranea mk4.003452.03   Pseudouridine-5'-monophosphatase
Schmidtea mediterranea mk4.049863.01  
Schmidtea mediterranea mk4.000412.07   Pseudouridine-5'-monophosphatase
Trichomonas vaginalis TVAG_117360   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_481930   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_398770   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_440810   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_417190   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_005730   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_430570   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_133450   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_007160   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_145590   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_133950   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_110720   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_023520   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_372950   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_547260   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_488000   2-deoxyglucose-6-phosphate phosphatase, putative

Essentiality

TVAG_372950 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b1317 Escherichia coli non-essential goodall
b1727 Escherichia coli non-essential goodall
b2690 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_372950 (Trichomonas vaginalis), 2-deoxyglucose-6-phosphate phosphatase, putative
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