Detailed view for TVAG_335880

Basic information

TDR Targets ID: 914838
Trichomonas vaginalis, phosphofructokinase, putative
Source Database / ID: 

pI: 6.384 | Length (AA): 432 | MW (Da): 48159 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00365   Phosphofructokinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0047334   diphosphate-fructose-6-phosphate 1-phosphotransferase activity  
GO:0003872   6-phosphofructokinase activity  
GO:0006096   glycolysis  
GO:0006002   fructose 6-phosphate metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131114)

Species Accession Gene Product
Arabidopsis thaliana AT4G04040   pyrophosphate--fructose-6-phosphate 1-phosphotransferase
Arabidopsis thaliana AT1G12000   pyrophosphate--fructose-6-phosphate 1-phosphotransferase subunit beta 1
Babesia bovis BBOV_II006170   6-phosphofructokinase, putative
Cryptosporidium hominis Chro.30172   pyrophosphate-dependent phosphofructokinase
Cryptosporidium hominis Chro.20231   hypothetical protein
Cryptosporidium parvum cgd2_2130   pyrophosphate-dependent phosphofructokinase
Cryptosporidium parvum cgd3_1400   pyrophosphate-dependent 6-phosphofructokinase
Chlamydia trachomatis CT_207   fructose-6-phosphate phosphotransferase
Chlamydia trachomatis CT_205   fructose-6-phosphate phosphotransferase
Entamoeba histolytica EHI_000730   pyrophosphate-dependent phosphofructokinase
Giardia lamblia GL50803_14993   Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit
Neospora caninum NCLIV_046050   hypothetical protein
Neospora caninum NCLIV_017040   Phosphofructokinase, related
Oryza sativa 4340643   Os06g0247500
Plasmodium berghei PBANKA_0816400   ATP-dependent 6-phosphofructokinase, putative
Plasmodium falciparum PF3D7_0915400   ATP-dependent 6-phosphofructokinase
Plasmodium knowlesi PKNH_0713400   ATP-dependent 6-phosphofructokinase, putative
Plasmodium vivax PVX_099200   6-phosphofructokinase, putative
Plasmodium yoelii PY01321   pyrophosphate-dependent phosphofructokinase
Toxoplasma gondii TGME49_240890   6-phosphofructokinase
Toxoplasma gondii TGME49_226960   phosphofructokinase PFKII
Treponema pallidum TP0542   diphosphate--fructose-6-phosphate 1-phosphotransferase
Theileria parva TP02_0577   6-phosphofructokinase, putative
Trichomonas vaginalis TVAG_263690   phosphofructokinase, putative
Trichomonas vaginalis TVAG_079260   phosphofructokinase, putative
Trichomonas vaginalis TVAG_077440   6-phosphofructokinase, putative
Trichomonas vaginalis TVAG_364620   phosphofructokinase, putative
Trichomonas vaginalis TVAG_430830   phosphofructokinase, putative
Trichomonas vaginalis TVAG_335880   phosphofructokinase, putative
Trichomonas vaginalis TVAG_281070   phosphofructokinase, putative

Essentiality

TVAG_335880 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0816400 Plasmodium berghei Essential plasmo
TGME49_226960 Toxoplasma gondii Probably essential sidik
TGME49_240890 Toxoplasma gondii Probably essential sidik
TGME49_226960 Toxoplasma gondii Probably non-essential sidik
TGME49_240890 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0719 0.2678 0.2677
0.0703 0.2605 0.2605
0.0647 0.2652 0.2645
0.0647 0.2652 0.2645
0.0031 0.2567 0.2567
0.0703 0.2605 0.2605
0.0547 0.2531 0
0.069 0.2605 0.2605
0.0717 0.2684 0.2684
0.0692 0.2606 0.2606
0.0719 0.2676 0.2676
0.0311 0.2594 0.2594
0.0571 0.2636 0.2636
0.0641 0.2555 0
0.0443 0.2618 0.255
0.0586 0.2581 0.2581
0.0634 0.2651 0.2621
0.0647 0.2652 0.2645
0.0091 0.2539 0.2196
0.0704 0.266 0.2649
0.023 0.2538 0
0.0704 0.266 0.2649
0.009 0.257 0.2563
0.0547 0.2531 0
0.0524 0.2643 0.2591
0.0704 0.266 0.2649
0.0234 0.2617 0.2591
0.0809 0.2645 0.2546
0.0698 0.2632 0.2607

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_335880 (Trichomonas vaginalis), phosphofructokinase, putative
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