pI: 8.5203 |
Length (AA): 803 |
MW (Da): 91425 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128181)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G60490 | phosphatidylinositol 3-kinase VPS34 |
Babesia bovis | BBOV_I002970 | phosphatidylinositol 3- and 4-kinase domain containing protein |
Brugia malayi | Bm1_09860 | Phosphatidylinositol 3- and 4-kinase family protein |
Candida albicans | CaO19.6243 | phosphatidylinositol 3-kinase |
Candida albicans | CaO19.13621 | phosphatidylinositol 3-kinase |
Caenorhabditis elegans | CELE_B0025.1 | Protein VPS-34, isoform A |
Cryptosporidium hominis | Chro.60213 | phosphatidylinositol 3-kinase, root isoform |
Cryptosporidium parvum | cgd6_1760 | phosphatidylinositol 3-kinase; PI3ka plus PI3Kc domains |
Dictyostelium discoideum | DDB_G0289601 | phosphatidylinositol 3-kinase |
Drosophila melanogaster | Dmel_CG5373 | Phosphotidylinositol 3 kinase 59F |
Echinococcus granulosus | EgrG_000747800 | phosphatidylinositol 3 kinase catalytic subunit |
Entamoeba histolytica | EHI_096560 | phosphatidylinositol 3-kinase, putative |
Echinococcus multilocularis | EmuJ_000747800 | Zinc finger, PHD finger |
Homo sapiens | 5289 | phosphatidylinositol 3-kinase, catalytic subunit type 3 |
Leishmania braziliensis | LbrM.24.2090 | phosphatidylinositol 3-kinase, putative |
Leishmania donovani | LdBPK_242090.1 | phosphatidylinositol 3-kinase, putative |
Leishmania infantum | LinJ.24.2090 | phosphatidylinositol 3-kinase, putative |
Leishmania major | LmjF.24.2010 | phosphatidylinositol 3-kinase, putative |
Leishmania mexicana | LmxM.24.2010 | phosphatidylinositol 3-kinase, putative |
Loa Loa (eye worm) | LOAG_11596 | phosphatidylinositol 3 |
Loa Loa (eye worm) | LOAG_06080 | phosphatidylinositol 3 |
Mus musculus | ENSMUSG00000033628 | phosphoinositide-3-kinase, class 3 |
Neospora caninum | NCLIV_052580 | phosphatidylinositol 3-kinase, putative |
Oryza sativa | 4337982 | Os05g0180600 |
Oryza sativa | 4345232 | Os08g0307400 |
Plasmodium berghei | PBANKA_1114900 | phosphatidylinositol 3-kinase, putative |
Plasmodium falciparum | PF3D7_0515300 | phosphatidylinositol 3-kinase |
Plasmodium knowlesi | PKNH_1017900 | phosphatidylinositol 3-kinase, putative |
Plasmodium vivax | PVX_080480 | phosphatidylinositol 3-kinase, putative |
Plasmodium yoelii | PY00334 | phosphatidylinositol 3-kinase vps34-like |
Saccharomyces cerevisiae | YLR240W | phosphatidylinositol 3-kinase VPS34 |
Schistosoma japonicum | Sjp_0097580 | expressed protein |
Schistosoma japonicum | Sjp_0201680 | ko:K00914 phosphatidylinositol 3-kinase [EC2.7.1.137], putative |
Schistosoma japonicum | Sjp_0311720 | ko:K00914 phosphatidylinositol 3-kinase [EC2.7.1.137], putative |
Schistosoma mansoni | Smp_128130 | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K |
Schmidtea mediterranea | mk4.016041.01 | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
Schmidtea mediterranea | mk4.012968.01 | |
Schmidtea mediterranea | mk4.012968.00 | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
Trypanosoma brucei gambiense | Tbg972.8.6270 | phosphatidylinositol 3-kinase, putative,PI3-kinase, putative |
Trypanosoma brucei | Tb927.8.6210 | phosphatidylinositol 3-kinase, putative |
Trypanosoma congolense | TcIL3000_8_6050 | phosphatidylinositol 3-kinase, putative |
Trypanosoma cruzi | TcCLB.511067.4 | phosphatidylinositol 3-kinase, putative |
Trypanosoma cruzi | TcCLB.511903.160 | phosphatidylinositol 3-kinase vps34-like |
Toxoplasma gondii | TGME49_215700 | phosphatidylinositol 3- and 4-kinase |
Trichomonas vaginalis | TVAG_045170 | phosphatidylinositol 3-kinase class, putative |
Trichomonas vaginalis | TVAG_006610 | phosphatidylinositol kinase, putative |
Trichomonas vaginalis | TVAG_247270 | phosphatidylinositol 3-kinase class, putative |
Trichomonas vaginalis | TVAG_332500 | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.6210 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.6210 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.6210 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.6210 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_B0025.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_B0025.1 | Caenorhabditis elegans | slow growth | wormbase |
YLR240W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1114900 | Plasmodium berghei | Essential | plasmo |
TGME49_215700 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | phosphatidylinositol 3-kinase, catalytic subunit type 3 | Compounds | References |