Detailed view for TVAG_200340

Basic information

TDR Targets ID: 924014
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 6.5896 | Length (AA): 568 | MW (Da): 64382 | Paralog Number: 88

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00443   Ubiquitin carboxyl-terminal hydrolase
PF13359   DDE superfamily endonuclease

Gene Ontology

Mouse over links to read term descriptions.
GO:0036459   GO:thiol-dependent ubiquitinyl hydrolase activity  

GO:0016579   protein deubiquitination  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128570)

Species Accession Gene Product
Trichomonas vaginalis TVAG_027950   conserved hypothetical protein
Trichomonas vaginalis TVAG_393800   conserved hypothetical protein
Trichomonas vaginalis TVAG_448510   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_360300   conserved hypothetical protein
Trichomonas vaginalis TVAG_522320   conserved hypothetical protein
Trichomonas vaginalis TVAG_138640   conserved hypothetical protein
Trichomonas vaginalis TVAG_399120   conserved hypothetical protein
Trichomonas vaginalis TVAG_126000   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_217440   conserved hypothetical protein
Trichomonas vaginalis TVAG_055770   conserved hypothetical protein
Trichomonas vaginalis TVAG_358660   conserved hypothetical protein
Trichomonas vaginalis TVAG_567110   conserved hypothetical protein
Trichomonas vaginalis TVAG_015330   conserved hypothetical protein
Trichomonas vaginalis TVAG_529040   conserved hypothetical protein
Trichomonas vaginalis TVAG_TEG_DS113381_1_1   Harbinger-1_Harbinger/PIFA2 transposable element protein
Trichomonas vaginalis TVAG_443890   conserved hypothetical protein
Trichomonas vaginalis TVAG_018600   conserved hypothetical protein
Trichomonas vaginalis TVAG_496710   conserved hypothetical protein
Trichomonas vaginalis TVAG_342140   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_601100   conserved hypothetical protein
Trichomonas vaginalis TVAG_579370   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_528850   conserved hypothetical protein
Trichomonas vaginalis TVAG_517480   conserved hypothetical protein
Trichomonas vaginalis TVAG_443900   conserved hypothetical protein
Trichomonas vaginalis TVAG_374390   conserved hypothetical protein
Trichomonas vaginalis TVAG_561780   conserved hypothetical protein
Trichomonas vaginalis TVAG_378670   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_334990   conserved hypothetical protein
Trichomonas vaginalis TVAG_RG_DS120871_1   hypothetical protein
Trichomonas vaginalis TVAG_601680   conserved hypothetical protein
Trichomonas vaginalis TVAG_091460   conserved hypothetical protein
Trichomonas vaginalis TVAG_428750   conserved hypothetical protein
Trichomonas vaginalis TVAG_552700   conserved hypothetical protein
Trichomonas vaginalis TVAG_427190   conserved hypothetical protein
Trichomonas vaginalis TVAG_397780   conserved hypothetical protein
Trichomonas vaginalis TVAG_200340   conserved hypothetical protein
Trichomonas vaginalis TVAG_585620   conserved hypothetical protein
Trichomonas vaginalis TVAG_491380   conserved hypothetical protein
Trichomonas vaginalis TVAG_537550   conserved hypothetical protein
Trichomonas vaginalis TVAG_502990   conserved hypothetical protein
Trichomonas vaginalis TVAG_589300   conserved hypothetical protein
Trichomonas vaginalis TVAG_280960   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_601690   conserved hypothetical protein
Trichomonas vaginalis TVAG_374430   conserved hypothetical protein
Trichomonas vaginalis TVAG_446350   conserved hypothetical protein
Trichomonas vaginalis TVAG_593380   conserved hypothetical protein
Trichomonas vaginalis TVAG_605050   conserved hypothetical protein
Trichomonas vaginalis TVAG_358650   conserved hypothetical protein
Trichomonas vaginalis TVAG_443110   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_280950   conserved hypothetical protein
Trichomonas vaginalis TVAG_376020   conserved hypothetical protein
Trichomonas vaginalis TVAG_279780   conserved hypothetical protein
Trichomonas vaginalis TVAG_522210   conserved hypothetical protein
Trichomonas vaginalis TVAG_564990   conserved hypothetical protein
Trichomonas vaginalis TVAG_086410   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_514100   conserved hypothetical protein
Trichomonas vaginalis TVAG_267520   conserved hypothetical protein
Trichomonas vaginalis TVAG_151190   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_135750   conserved hypothetical protein
Trichomonas vaginalis TVAG_TEG_DS113561_1_1   Harbinger-1_Harbinger/PIFA2 transposable element protein
Trichomonas vaginalis TVAG_126250   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_TEG_DS113207_2_1   Harbinger-1_Harbinger/PIFA2 transposable element protein
Trichomonas vaginalis TVAG_547760   conserved hypothetical protein
Trichomonas vaginalis TVAG_532530   conserved hypothetical protein
Trichomonas vaginalis TVAG_051620   conserved hypothetical protein
Trichomonas vaginalis TVAG_377480   conserved hypothetical protein
Trichomonas vaginalis TVAG_288050   conserved hypothetical protein
Trichomonas vaginalis TVAG_588360   conserved hypothetical protein
Trichomonas vaginalis TVAG_546440   conserved hypothetical protein
Trichomonas vaginalis TVAG_536580   conserved hypothetical protein
Trichomonas vaginalis TVAG_360310   conserved hypothetical protein
Trichomonas vaginalis TVAG_027940   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_279770   conserved hypothetical protein
Trichomonas vaginalis TVAG_TEG_DS113729_1_1   Harbinger-1_Harbinger/PIFA2 transposable element protein
Trichomonas vaginalis TVAG_528100   conserved hypothetical protein
Trichomonas vaginalis TVAG_522200   conserved hypothetical protein
Trichomonas vaginalis TVAG_389710   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_587070   conserved hypothetical protein
Trichomonas vaginalis TVAG_573650   conserved hypothetical protein
Trichomonas vaginalis TVAG_559990   conserved hypothetical protein
Trichomonas vaginalis TVAG_TEG_DS113381_1_2   Harbinger-1_Harbinger/PIFA2 transposable element protein
Trichomonas vaginalis TVAG_341940   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_525300   conserved hypothetical protein
Trichomonas vaginalis TVAG_511360   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_TEG_DS113283_1_1   PIF1 transposable element protein
Trichomonas vaginalis TVAG_374400   conserved hypothetical protein
Trichomonas vaginalis TVAG_RG_DS114161_2   hypothetical protein
Trichomonas vaginalis TVAG_577470   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_300050   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0003 0.5 0.5
0.0004 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_200340 (Trichomonas vaginalis), conserved hypothetical protein
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