Detailed view for TVAG_462340

Basic information

TDR Targets ID: 927344
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 7.1846 | Length (AA): 509 | MW (Da): 57396 | Paralog Number: 8

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00644   Poly(ADP-ribose) polymerase catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0003950   NAD+ ADP-ribosyltransferase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132219)

Species Accession Gene Product
Homo sapiens ENSG00000151883   poly (ADP-ribose) polymerase family, member 8
Homo sapiens ENSG00000137817   poly (ADP-ribose) polymerase family, member 6
Mus musculus ENSMUSG00000025237   poly (ADP-ribose) polymerase family, member 6
Mus musculus ENSMUSG00000021725   poly (ADP-ribose) polymerase family, member 8
Trichomonas vaginalis TVAG_246270   conserved hypothetical protein
Trichomonas vaginalis TVAG_412550   conserved hypothetical protein
Trichomonas vaginalis TVAG_226320   conserved hypothetical protein
Trichomonas vaginalis TVAG_462340   conserved hypothetical protein
Trichomonas vaginalis TVAG_477690   conserved hypothetical protein
Trichomonas vaginalis TVAG_307210   conserved hypothetical protein
Trichomonas vaginalis TVAG_174840   conserved hypothetical protein
Trichomonas vaginalis TVAG_368980   conserved hypothetical protein
Trichomonas vaginalis TVAG_117520   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens poly (ADP-ribose) polymerase family, member 6 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0202 0.272 1
0.0266 0.2648 0.5
0.0296 0.5452 1
0.0118 0.2988 1
0.0094 0.3211 0.3211
0.0281 0.5386 1
0.0348 0.4439 1
0.0216 0.272 1
0.0153 0.3183 1
0.031 0.5084 1
0.03 0.5565 1
0.0399 0.3455 1
0.012 0.2743 1
0.0321 0.4801 1
0.0236 0.5096 0.5099
0.0351 0.4167 1
0.0308 0.323 1
0.0304 0.2846 1
0.0143 0.4887 1
0.0343 0.4507 1
0.0296 0.5452 1
0.044 0.2965 1
0.03 0.5566 1
0.0157 0.2743 1
0.0272 0.5565 1
0.0137 0.2743 1
0.0266 0.2648 0.5
0.0266 0.2648 0.5
0.0283 0.565 1
0.0082 0.3219 1
0.0439 0.2985 0.9268
0.0343 0.3071 1
0.0097 0.366 1
0.014 0.6429 1
0.0272 0.5565 1
0.0295 0.5622 1
0.0328 0.278 1
0.0273 0.5676 1
0.0099 0.4005 1
0.029 0.5386 1
0.0234 0.2782 1
0.0133 0.3183 1
0.0271 0.538 1
0.0099 0.4005 1
0.0173 0.2584 0.8309
0.0133 0.4814 0.566
0.0296 0.2723 1
0.011 0.5854 1
0.0295 0.5622 1
0.0216 0.272 1
0.0118 0.2988 1
0.0266 0.2648 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_462340 (Trichomonas vaginalis), conserved hypothetical protein
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