Detailed view for Tb11.v5.0285

Basic information

TDR Targets ID: 932291
Trypanosoma brucei, variant surface protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.3809 | Length (AA): 239 | MW (Da): 25326 | Paralog Number: 11

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00913   Trypanosome variant surface glycoprotein (A-type)

Gene Ontology

Mouse over links to read term descriptions.
GO:0020012   evasion or tolerance of host immune response  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

PDB tag
  • 2VSG:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_135913)

Species Accession Gene Product
Trypanosoma brucei Tb927.5.5080   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.v5.0389   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb11.v5.0135   variant surface protein (VSG), putative
Trypanosoma brucei Tb11.v5.0894   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.v5.1017   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.9.1050   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.1450   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.11.17190   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.v5.0285   variant surface protein, putative
Trypanosoma brucei Tb927.3.180   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb927.11.18050   variant surface glycoprotein (VSG), frameshifted
Trypanosoma brucei Tb11.v5.0936   variant surface glycoprotein (VSG, atypical), putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Tb11.v5.0285 (Trypanosoma brucei), variant surface protein, putative
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