Detailed view for Tb11.v5.0702

Basic information

TDR Targets ID: 933623
Trypanosoma brucei, calpain-like cysteine peptidase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.8207 | Length (AA): 730 | MW (Da): 82394 | Paralog Number: 9

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_130635)

Species Accession Gene Product
Leishmania braziliensis LbrM.27.0610   calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania braziliensis LbrM.27.0620   calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania braziliensis LbrM.27.2140   calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania braziliensis LbrM.27.0600   calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania donovani LdBPK_270510.1   calpain-like cysteine peptidase, putative
Leishmania infantum LinJ.27.0500   calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania infantum LinJ.27.2520   cysteine peptidase, Clan CA, family C2, putative
Leishmania infantum LinJ.27.2490   calpain-like cysteine peptidase
Leishmania infantum LinJ.27.0510   calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania major LmjF.27.0490   calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania major LmjF.27.0500   calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania major LmjF.27.0510   calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania mexicana LmxM.27.0500   calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania mexicana LmxM.27.0490   calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative
Leishmania mexicana LmxM.27.0510   calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative
Trypanosoma brucei gambiense Tbg972.11.1180   calpain-like protein, putative
Trypanosoma brucei gambiense Tbg972.11.1190   calpain-like cysteine peptidase, putative,antigen, putative,cysteine peptidase, Clan CA, family C2, putative
Trypanosoma brucei gambiense Tbg972.11.1170  
Trypanosoma brucei Tb11.v5.0432   calpain-like cysteine peptidase, putative
Trypanosoma brucei Tb927.11.1130   calpain-like cysteine peptidase, putative
Trypanosoma brucei Tb427tmp.11.0001   hypothetical protein
Trypanosoma brucei Tb11.v5.1010   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.11.1090   calpain-like protein, putative
Trypanosoma brucei Tb11.v5.1011   calpain-like cysteine peptidase, putative
Trypanosoma brucei Tb11.v5.1038   calpain-like cysteine peptidase, putative
Trypanosoma brucei Tb927.11.1100   cysteine peptidase, Clan CA, family C2, putative
Trypanosoma brucei Tb927.11.1110   calpain, putative
Trypanosoma brucei Tb11.v5.0702   calpain-like cysteine peptidase, putative
Trypanosoma congolense TcIL3000.11.1030   cysteine peptidase, Clan CA, family C2, putative
Trypanosoma congolense TcIL3000_0_11260   calpain, putative
Trypanosoma cruzi TcCLB.511445.10   calpain-like cysteine peptidase, putative
Trypanosoma cruzi TcCLB.511441.10   calpain cysteine peptidase, putative
Trypanosoma cruzi TcCLB.509013.10   calpain-like cysteine peptidase, putative
Trypanosoma cruzi TcCLB.445281.9   calpain-like cysteine peptidase, putative
Trypanosoma cruzi TcCLB.506721.30   cysteine peptidase, Clan CA, family C2, putative

Essentiality

Tb11.v5.0702 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.v4.0001 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.v4.0001 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.v4.0001 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.v4.0001 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.47.0036 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.47.0036 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.47.0036 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.47.0036 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.47.0035 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.47.0035 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.47.0035 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.47.0035 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.57.0008 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.57.0008 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.57.0008 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.57.0008 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Compounds References
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Compounds References
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Protein Rev Compounds References
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 REV Compounds References
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0572 0.2905 0.2895
0.0265 0.2852 0.3206
0.0119 0.3132 1
0.0141 0.2766 0.2658
0.0309 0.2923 0.2895
0.012 0.2969 1
0.011 0.254 1
0.0286 0.3029 0.3013
0.0282 0.2808 0.2788
0.0202 0.2926 0.2926
0.0109 0.258 0.5
0.0257 0.2747 0.2611
0.0258 0.302 0.3013
0.0258 0.302 0.3013
0.0232 0.2675 1
0.0259 0.2727 0.3164
0.0296 0.2927 0.2984
0.0307 0.2987 0.2984
0.0108 0.6027 0
0.0272 0.2832 0.2825
0.0283 0.2867 0.2865
0.0264 0.2519 0.3152
0.0312 0.2987 0.2984
0.0315 0.2766 0.2698
0.0251 0.2707 1
0.0296 0.2927 0.2984
0.0259 0.2727 0.3164
0.0307 0.2987 0.2984
0.0284 0.2787 0.2763
0.012 0.2925 1
0.031 0.3035 0.3031
0.0135 0.2877 0.5
0.011 0.254 1
0.0111 0.293 1
0.0309 0.2923 0.2895
0.0111 0.2802 1
0.011 0.258 0.5
0.0269 0.2535 0.2801
0.0109 0.3129 0.8416
0.026 0.2633 0.2987
0.0315 0.3421 0.3421
0.0315 0.3421 0.3421
0.0255 0.2943 0.2938
0.0135 0.2877 1
0.0303 0.2806 0.2789
0.0281 0.2938 0.2938
0.0379 0.3309 1
0.0271 0.2923 0.2895
0.0263 0.3033 0.3231
0.0272 0.302 0.3013
0.0277 0.2851 0.2851
0.0315 0.2867 0.2865
0.0225 0.2703 1
0.0315 0.3029 0.3025
0.012 0.3371 1
0.024 0.2684 1
0.0114 0.2818 1
0.0063 0.2963 1
0.0631 0.2895 0.2895
0.0344 0.2513 0.302
0.0282 0.2867 0.2865
0.0253 0.2938 0.2938
0.024 0.2668 1
0.031 0.3035 0.3031
0.0108 0.258 0.5
0.0261 0.2842 0.2809
0.0269 0.2718 0.3031
0.0262 0.2938 0.2938
0.0599 0.2905 0.2895
0.0255 0.2657 0.2895
0.0257 0.2779 0.2779
0.011 0.3432 1
0.0635 0.2905 0.2895
0.0284 0.294 0.294
0.0365 0.9441 1
0.0269 0.2718 0.3031
0.02 0.2787 0.2658
0.0286 0.2968 0.2984
0.0126 0.3176 1
0.0131 0.3365 1
0.0122 0.264 1
0.0116 0.2986 1
0.0631 0.2905 0.2895
0.0278 0.2858 0.2865
0.0256 0.2824 0.3227
0.0262 0.2938 0.2938
0.0262 0.3029 0.3013
0.0271 0.3013 0.3013
0.0259 0.2885 0.2855
0.0229 0.2658 1
0.012 0.2877 0.5
0.0116 0.2986 1
0.0202 0.2926 0.2926
0.0113 0.2878 0.1948
0.0247 0.6739 0.5
0.0541 0.2905 0.2895
0.0253 0.2674 0.2672
0.0303 0.2938 0.2938
0.0121 0.313 1
0.0286 0.2923 0.2895
0.0135 0.3132 1
0.0262 0.2938 0.2938
0.0251 0.2707 1
0.031 0.2987 0.2984
0.0631 0.2922 0.2895
0.0202 0.2907 0.2895
0.0129 0.3 1
0.0108 0.3005 1
0.0119 0.3403 0.5
0.0063 0.2947 1
0.01 0.2577 0.5
0.0294 0.2853 0.2853
0.0256 0.2588 0.3245
0.0275 0.3029 0.3013
0.0257 0.2825 0.2825
0.0256 0.2867 0.2865
0.0315 0.3029 0.3025
0.0218 1 0.5
0.0261 0.2842 0.2809
0.0256 0.2588 0.3245
0.0257 0.3441 0.3421
0.0604 0.2905 0.2895
0.0237 0.2675 1
0.0599 0.2905 0.2895
0.0135 0.3303 1
0.0275 0.2633 0.3013
0.0635 0.2905 0.2895
0.0271 0.2938 0.2938
0.0264 0.2923 0.2895
0.0278 0.2692 0.2908
0.0631 0.2922 0.2895
0.0257 0.2938 0.2938
0.0118 0.6794 0
0.0231 0.2703 1
0.0262 0.2938 0.2938
0.011 0.3245 0.5
0.0255 0.2657 0.2895
0.0122 0.3104 1
0.0063 0.2963 1
0.0309 0.2938 0.2938
0.0135 0.2941 1
0.0225 0.2628 1
0.0599 0.2905 0.2895
0.0315 0.2805 0.2805
0.0309 0.2923 0.2895
0.0255 0.2943 0.2938
0.0568 0.2905 0.2895
0.0224 0.262 1
0.0284 0.2857 0.2874
0.0109 0.3382 1
0.0228 0.2699 1
0.011 0.254 1
0.0572 0.2905 0.2895
0.0229 0.2639 1
0.0302 0.2915 0.2835
0.0266 0.3029 0.3013
0.0135 0.2819 1
0.0284 0.294 0.294
0.0286 0.2938 0.2938
0.0121 0.2877 0.5
0.0109 0.3037 1
0.0262 0.2938 0.2938
0.0315 0.3421 0.3421
0.0251 0.2707 1
0.0081 1 1
0.0465379 0.258484 0.251193
0.0081 1 1
0.0118 0.6794 0
0.011 0.254 1
0.0135 0.2819 1
0.0244 0.2704 1
0.024 0.2712 1
0.0135 0.3303 1
0.0224 0.2549 1
0.0257 0.276 0.3391
0.0268 0.2923 0.2895
0.0465379 0.258484 0.251193
0.0272 0.2855 0.2855
0.0135 0.3206 1
0.0604 0.2905 0.2895
0.0263 0.2832 0.2825
0.0213 0.4015 1
0.0243 0.2685 1
0.024 0.2684 1
0.0456 0.2905 0.2895
0.0271 0.2726 0.266
0.0347 0.724 1
0.0276 0.2923 0.2895
0.0266 0.2832 0.2831
0.007 0.2944 1
0.0379 0.3309 1
0.0304 0.2987 0.2984
0.0296 0.2878 0.2984
0.0135 0.2819 1
0.0253 0.2938 0.2938
0.0277 0.279 0.2815
0.0063 0.2947 1
0.0568 0.2905 0.2895
0.0572 0.2905 0.2895
0.0268 0.2851 0.2851
0.0286 0.2895 0.2895
0.0135 0.2968 1
0.0263 0.2837 0.3203
0.0135 0.2658 1
0.0255 0.2938 0.2938
0.0257 1 1
0.0256 0.302 0.3013
0.0111 0.3238 1
0.0253 0.3015 0.2984
0.0269 0.2923 0.2895
0.0281 0.2591 0.2872
0.0541 0.2905 0.2895
0.011 0.2952 1
0.0119 0.3346 1
0.0229 0.2644 1
0.0379 0.3309 1
0.026 0.2855 0.2855
0.0365 0.9441 1
0.0281 0.2938 0.2938
0.01 0.2656 0.5
0.0304 0.2987 0.2984
0.0063 0.2941 1
0.0267 0.2613 0.2865
0.0251 0.2707 1
0.012 0.2625 0
0.0297 0.2938 0.2938
0.011 0.385 0.5
0.0253 0.28 0.3031
0.0315 0.3421 0.3421
0.0204 0.3078 0.3072
0.0081 1 1
0.0251 0.2707 1
0.0599 0.2905 0.2895
0.0604 0.2905 0.2895
0.0379 0.3309 1
0.0271 0.2938 0.2938
0.0269 0.3029 0.3013
0.0233 0.2675 1
0.0286 0.2923 0.2895
0.0111 0.2739 0.5
0.0285 0.2882 0.2861
0.0251 0.2707 1
0.0133 0.3202 0.6637
0.0637 0.2922 0.2895
0.0135 0.3206 1
0.0119 0.2588 1
0.0292 0.3029 0.3014
0.0109 0.3594 0.5
0.0261 0.2797 0.2729
0.0546387 0.258362 0.251193
0.0278 0.256 0.2869
0.031 0.3035 0.3031
0.0303 0.2806 0.2789
0.0134 0.8372 0
0.028 0.2669 0.2895
0.01 0.2577 0.5
0.0631 0.2905 0.2895
0.0109 0.3037 1
0.0269 0.2718 0.3031
0.0255 0.2657 0.2895
0.0315 0.3029 0.3025
0.0256 0.2987 0.2984
0.0232 1 0.5
0.0284 0.294 0.294
0.0312 0.2939 0.2938
0.028 0.2669 0.2895
0.0265 0.2852 0.3206
0.0315 0.2982 0.2968
0.0135 0.3995 0.5
0.0256 0.2987 0.2984
0.0255 0.2773 0.2658
0.024 0.2694 1
0.0306 0.2923 0.2895
0.0105 0.5 0.5
0.0143 0.2895 0.2895
0.0292 0.2923 0.2895
0.0081 1 1
0.0274 0.2725 0.281
0.0635 0.2905 0.2895
0.0141 0.2658 0.2658
0.0296 0.2983 0.3008
0.0135 0.2764 0.5
0.0312 0.2987 0.2984
0.0231 0.2703 1
0.011 0.2715 0.5
0.0292 0.2955 0.2955
0.0307 0.3029 0.3014
0.0135 0.3371 1
0.0264 0.2944 0.2938
0.0267 0.2613 0.2865
0.0268 0.2923 0.2895

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Tb11.v5.0702 (Trypanosoma brucei), calpain-like cysteine peptidase, putative
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